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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kcna1
potassium voltage-gated channel, shaker-related subfamily, member 1
MGI:96654
56 phenotypes from 3 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kcna1mceph/Kcna1mceph
BALB/cByJ-Kcna1mceph/J 		abnormal astrocyte morphology J:38104
abnormal brain development J:38104
abnormal brain morphology J:38104, J:119491
abnormal brain size J:38104
abnormal gait J:38104
abnormal hearing physiology J:119491
abnormal locomotor behavior J:119491
abnormal posture J:38104, J:119491
abnormal reflex J:38104
abnormal sexual interaction J:38104
chromodacryorrhea J:38104
convulsive seizures J:89910, J:119491
decreased body size J:38104
ear inflammation J:119491
enlarged hippocampus J:119491
excessive tearing J:38104
eye inflammation J:119491
increased brain size J:38104, J:89909
increased brain weight J:38104
increased startle reflex J:119491
seizures J:89910
tonic-clonic seizures J:89910
tremors J:119491
Kcna1tm1Jmay/Kcna1+
B6.129S4-Kcna1tm1Jmay 		abnormal inhibitory postsynaptic currents J:82778
abnormal motor coordination/balance J:82778
normal behavior/neurological phenotype J:82778
Kcna1tm1Jmay/Kcna1tm1Jmay
B6.129S4-Kcna1tm1Jmay 		embryonic lethality, complete penetrance J:82778
Kcna1tm1Tem/Kcna1+
involves: 129S7/SvEvBrd * various 		increased susceptibility to pharmacologically induced seizures J:47349
Kcna1tm1Tem/Kcna1tm1Tem
C3Fe.129S7-Kcna1tm1Tem 		abnormal action potential J:105296
abnormal mitochondrial ATP synthesis coupled electron transport J:206598
abnormal nervous system electrophysiology J:105296
decreased chemical nociceptive threshold J:107933
decreased chemically-elicited antinociception J:107933
decreased nerve fiber response threshold J:105296
decreased paired-pulse ratio J:206598
decreased thermal nociceptive threshold J:107933
oxidative stress J:206598
seizures J:206598
Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd 		abnormal cardiovascular system physiology J:164091
abnormal impulse conducting system conduction J:164091
atrioventricular block J:164091
decreased heart rate J:164091
myoclonus J:164091
postnatal lethality, incomplete penetrance J:164091
premature death J:164091
seizures J:164091
tonic-clonic seizures J:164091
ventricular premature beat J:164091
Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * BALB/cByJ * C3HeB/FeJ 		abnormal cerebral cortex morphology J:119491
abnormal hearing physiology J:119491
abnormal locomotor behavior J:119491
abnormal posture J:119491
convulsive seizures J:119491
ear inflammation J:119491
enlarged hippocampus J:119491
eye inflammation J:119491
increased startle reflex J:119491
porphyria J:119491
tremors J:119491
Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * C57BL/6 		abnormal PNS synaptic transmission J:77281
ataxia J:77281
impaired balance J:77281
impaired swimming J:77281
seizures J:77281
tremors J:77281
Kcna1tm1Tem/Kcna1tm1Tem
involves: 129S7/SvEvBrd * various 		abnormal action potential J:47349
abnormal behavior J:47349
abnormal brain wave pattern J:47349
abnormal CNS synaptic transmission J:47349
abnormal paired-pulse facilitation J:47349
increased blinking frequency J:47349
increased startle reflex J:47349
increased susceptibility to pharmacologically induced seizures J:47349
premature death J:47349
seizures J:47349
tonic-clonic seizures J:47349
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory