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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kcna2
potassium voltage-gated channel, shaker-related subfamily, member 2
MGI:96659
31 phenotypes from 4 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kcna2em1(IMPC)H/Kcna2+
C57BL/6NTac-Kcna2em1(IMPC)H/H 		increased red blood cell distribution width J:211773
Kcna2em1(IMPC)H/Kcna2em1(IMPC)H
C57BL/6NTac-Kcna2em1(IMPC)H/H 		preweaning lethality, complete penetrance J:211773
Kcna2m1Btlr/Kcna2m1Btlr
C57BL/6J-Kcna2m1Btlr 		premature death J:274750
Kcna2Pgu/Kcna2+
involves: C3H/HeJ * C57BL/6J 		abnormal gait J:166795
abnormal inhibitory postsynaptic currents J:166795
abnormal miniature inhibitory postsynaptic currents J:166795
abnormal posture J:166795
abnormal single cell response J:166795
ataxia J:166795
decreased body size J:166795
decreased body weight J:166795
decreased grip strength J:166795
impaired ability to fire action potentials J:166795
impaired coordination J:166795
limb grasping J:166795
long stride length J:166795
tremors J:166795
Kcna2Pgu/Kcna2Pgu
involves: C3H/HeJ * C57BL/6J 		abnormal gait J:166795
abnormal inhibitory postsynaptic currents J:166795
abnormal miniature inhibitory postsynaptic currents J:166795
abnormal posture J:166795
abnormal single cell response J:166795
ataxia J:166795
decreased body size J:166795
decreased body weight J:166795
decreased grip strength J:166795
impaired ability to fire action potentials J:166795
impaired coordination J:166795
normal nervous system phenotype J:166795
postnatal growth retardation J:166795
postnatal lethality J:166795
premature death J:166795
tremors J:166795
Kcna2tm1Tem/Kcna2+
C3Fe.129S7-Kcna2tm1Tem 		impaired ability to fire action potentials J:131735
increased susceptibility to pharmacologically induced seizures J:131735
Kcna2tm1Tem/Kcna2tm1Tem
C3Fe.129S7-Kcna2tm1Tem 		abnormal action potential J:131735
abnormal channel response J:131735
abnormal nervous system electrophysiology J:131735
apnea J:131735
decreased body weight J:131735
impaired ability to fire action potentials J:131735
increased susceptibility to pharmacologically induced seizures J:131735
postnatal lethality, complete penetrance J:131735
tonic seizures J:131735
Kcna2tm1Tem/Kcna2tm1Tem
involves: 129S7/SvEvBrd 		abnormal brain wave pattern J:130097
abnormal sleep pattern J:130097
decreased body size J:130097
postnatal lethality, complete penetrance J:130097
seizures J:130097
Kcna2tm1Tem/Kcna2tm1Tem
involves: 129S7/SvEvBrd * C57BL/6 		normal behavior/neurological phenotype J:131735
postnatal lethality, complete penetrance J:131735
tonic seizures J:131735
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory