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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kcne1
potassium voltage-gated channel, Isk-related subfamily, member 1
MGI:96673
87 phenotypes from 5 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kcne12J/Kcne12J
C57BL/6J-Kcne12J/J 		abnormal auditory brainstem response J:82238
deafness J:82238
head bobbing J:82238
head tilt J:82238
Kcne1pkr/Kcne1+
C57BL/10J-Kcne1pkr 		absent linear vestibular evoked potential J:116914
Kcne1pkr/Kcne1pkr
C57BL/10J-Kcne1pkr 		abnormal inner ear morphology J:64772
abnormal otolith morphology J:64772
abnormal reflex J:116914
abnormal semicircular canal morphology J:64772
abnormal tectorial membrane morphology J:64772
absent cochlear hair cells J:64772
absent cochlear inner hair cells J:64772
absent cochlear outer hair cells J:64772
absent linear vestibular evoked potential J:116914
absent outer hair cell stereocilia J:64772
ataxia J:64772
circling J:64772, J:116914
collapsed Reissner membrane J:64772
deafness J:64772
head tossing J:64772
impaired swimming J:64772, J:116914
increased or absent threshold for auditory brainstem response J:64772
small scala media J:64772
Kcne1tm1b(EUCOMM)Hmgu/Kcne1tm1b(EUCOMM)Hmgu
C57BL/6N-Kcne1tm1b(EUCOMM)Hmgu/Ics 		abnormal auditory brainstem response J:211773
abnormal behavior J:211773
abnormal cued conditioning behavior J:211773
abnormal gait J:211773
abnormal locomotor behavior J:211773
abnormal motor capabilities/coordination/movement J:211773
abnormal startle reflex J:211773
decreased anxiety-related response J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased locomotor activity J:211773
decreased lymphocyte cell number J:211773
decreased prepulse inhibition J:211773
decreased startle reflex J:211773
decreased thigmotaxis J:211773
decreased total body fat amount J:211773
decreased vertical activity J:211773
head bobbing J:211773
hyperactivity J:211773
impaired righting response J:211773
increased blood urea nitrogen level J:211773
increased circulating alanine transaminase level J:211773
increased circulating alkaline phosphatase level J:211773
increased lean body mass J:211773
increased mean corpuscular volume J:211773
increased monocyte cell number J:211773
increased neutrophil cell number J:211773
tremors J:211773
trunk curl J:211773
Kcne1tm1Rdn/Kcne1tm1Rdn
involves: 129S6/SvEvTac 		abnormal myocardial fiber physiology J:53735
Kcne1tm1Rdn/Kcne1tm1Rdn
involves: 129S6/SvEvTac * Black Swiss 		abnormal myocardial fiber physiology J:53735
Kcne1tm1Sfh/Kcne1tm1Sfh
involves: 129S1/Sv 		abnormal circulating renin level J:77288
abnormal cochlea morphology J:37461
abnormal cochlear sensory epithelium morphology J:37461
abnormal crista ampullaris morphology J:37461, J:105528
abnormal crista ampullaris neuroepithelium morphology J:108905
abnormal digestive system physiology J:77288
abnormal ear physiology J:37461
abnormal feces composition J:77288
abnormal inner ear vestibule morphology J:37461, J:108905
abnormal posture J:105528
abnormal scala media morphology J:37461
abnormal semicircular canal morphology J:105528
abnormal stria vascularis morphology J:37461
abnormal vestibular dark cell morphology J:77288, J:108905
abnormal vestibular system physiology J:105528
absent organ of Corti J:37461
absent pinna reflex J:37461, J:105528
absent startle reflex J:37461
absent vestibuloocular reflex J:105528
bidirectional circling J:37461, J:105528
circling J:105528
cochlear ganglion degeneration J:37461
cochlear hair cell degeneration J:37461
collapsed Reissner membrane J:37461
decreased startle reflex J:105528
dehydration J:77288
head bobbing J:37461, J:105528
head tilt J:37461
hyperactivity J:37461
hypokalemia J:77288
impaired coordination J:37461
impaired limb coordination J:105528
impaired righting response J:37461, J:105528
impaired swimming J:37461, J:105528
increased blood osmolality J:77288
increased circulating aldosterone level J:77288
increased circulating chloride level J:77288
increased circulating sodium level J:77288
increased hematocrit J:77288
organ of Corti degeneration J:37461
prolonged QT interval J:77288
stereotypic behavior J:37461
unidirectional circling J:105528
utricular macular degeneration J:105528
vestibular dark cell degeneration J:77288
vestibular hair cell degeneration J:37461, J:108905
vestibular saccular macula degeneration J:105528
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory