Kcne1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kcne1
potassium voltage-gated channel, Isk-related subfamily, member 1
MGI:96673

87 phenotypes from 5 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kcne1^2J/Kcne1^2J C57BL/6J-Kcne1^2J/J	abnormal auditory brainstem response	J:82238
	deafness	J:82238
	head bobbing	J:82238
	head tilt	J:82238
Kcne1^pkr/Kcne1⁺ C57BL/10J-Kcne1^pkr	absent linear vestibular evoked potential	J:116914
Kcne1^pkr/Kcne1^pkr C57BL/10J-Kcne1^pkr	abnormal inner ear morphology	J:64772
	abnormal otolith morphology	J:64772
	abnormal reflex	J:116914
	abnormal semicircular canal morphology	J:64772
	abnormal tectorial membrane morphology	J:64772
	absent cochlear hair cells	J:64772
	absent cochlear inner hair cells	J:64772
	absent cochlear outer hair cells	J:64772
	absent linear vestibular evoked potential	J:116914
	absent outer hair cell stereocilia	J:64772
	ataxia	J:64772
	circling	J:64772, J:116914
	collapsed Reissner membrane	J:64772
	deafness	J:64772
	head tossing	J:64772
	impaired swimming	J:64772, J:116914
	increased or absent threshold for auditory brainstem response	J:64772
	small scala media	J:64772
Kcne1^{tm1b(EUCOMM)Hmgu}/Kcne1^{tm1b(EUCOMM)Hmgu} C57BL/6N-Kcne1^{tm1b(EUCOMM)Hmgu}/Ics	abnormal auditory brainstem response	J:211773
	abnormal behavior	J:211773
	abnormal cued conditioning behavior	J:211773
	abnormal gait	J:211773
	abnormal locomotor behavior	J:211773
	abnormal motor capabilities/coordination/movement	J:211773
	abnormal startle reflex	J:211773
	decreased anxiety-related response	J:211773
	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased locomotor activity	J:211773
	decreased lymphocyte cell number	J:211773
	decreased prepulse inhibition	J:211773
	decreased startle reflex	J:211773
	decreased thigmotaxis	J:211773
	decreased total body fat amount	J:211773
	decreased vertical activity	J:211773
	head bobbing	J:211773
	hyperactivity	J:211773
	impaired righting response	J:211773
	increased blood urea nitrogen level	J:211773
	increased circulating alanine transaminase level	J:211773
	increased circulating alkaline phosphatase level	J:211773
	increased lean body mass	J:211773
	increased mean corpuscular volume	J:211773
	increased monocyte cell number	J:211773
	increased neutrophil cell number	J:211773
	tremors	J:211773
	trunk curl	J:211773
Kcne1^tm1Rdn/Kcne1^tm1Rdn involves: 129S6/SvEvTac	abnormal myocardial fiber physiology	J:53735
Kcne1^tm1Rdn/Kcne1^tm1Rdn involves: 129S6/SvEvTac * Black Swiss	abnormal myocardial fiber physiology	J:53735
Kcne1^tm1Sfh/Kcne1^tm1Sfh involves: 129S1/Sv	abnormal circulating renin level	J:77288
	abnormal cochlea morphology	J:37461
	abnormal cochlear sensory epithelium morphology	J:37461
	abnormal crista ampullaris morphology	J:37461, J:105528
	abnormal crista ampullaris neuroepithelium morphology	J:108905
	abnormal digestive system physiology	J:77288
	abnormal ear physiology	J:37461
	abnormal feces composition	J:77288
	abnormal inner ear vestibule morphology	J:37461, J:108905
	abnormal posture	J:105528
	abnormal scala media morphology	J:37461
	abnormal semicircular canal morphology	J:105528
	abnormal stria vascularis morphology	J:37461
	abnormal vestibular dark cell morphology	J:77288, J:108905
	abnormal vestibular system physiology	J:105528
	absent organ of Corti	J:37461
	absent pinna reflex	J:37461, J:105528
	absent startle reflex	J:37461
	absent vestibuloocular reflex	J:105528
	bidirectional circling	J:37461, J:105528
	circling	J:105528
	cochlear ganglion degeneration	J:37461
	cochlear hair cell degeneration	J:37461
	collapsed Reissner membrane	J:37461
	decreased startle reflex	J:105528
	dehydration	J:77288
	head bobbing	J:37461, J:105528
	head tilt	J:37461
	hyperactivity	J:37461
	hypokalemia	J:77288
	impaired coordination	J:37461
	impaired limb coordination	J:105528
	impaired righting response	J:37461, J:105528
	impaired swimming	J:37461, J:105528
	increased blood osmolality	J:77288
	increased circulating aldosterone level	J:77288
	increased circulating chloride level	J:77288
	increased circulating sodium level	J:77288
	increased hematocrit	J:77288
	organ of Corti degeneration	J:37461
	prolonged QT interval	J:77288
	stereotypic behavior	J:37461
	unidirectional circling	J:105528
	utricular macular degeneration	J:105528
	vestibular dark cell degeneration	J:77288
	vestibular hair cell degeneration	J:37461, J:108905
	vestibular saccular macula degeneration	J:105528

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24