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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Krt1
keratin 1
MGI:96698
41 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Krt1em1(IMPC)Ccpcz/Krt1em1(IMPC)Ccpcz
C57BL/6NCrl-Krt1em1(IMPC)Ccpcz/Ccpcz 		abnormal epididymis morphology J:211773
abnormal heart morphology J:211773
abnormal lung morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
abnormal thymus morphology J:211773
decreased circulating chloride level J:211773
decreased grip strength J:211773
decreased NK cell number J:211773
enlarged heart J:211773
enlarged spleen J:211773
enlarged thymus J:211773
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
increased CD8-positive, naive alpha-beta T cell number J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased effector memory T-helper cell number J:211773
small epididymis J:211773
small testis J:211773
thick ventricular wall J:211773
Krt1Mhdadsk12/Krt1+
C3HeB/FeJ-Krt1Mhdadsk12 		abnormal skin pigmentation J:108758
acanthosis J:108758
blistering J:108758
hyperkeratosis J:108758
hyperpigmentation J:108758
scaly skin J:108758
Krt1Mhdadsk12/Krt1Mhdadsk12
C3HeB/FeJ-Krt1Mhdadsk12 		blistering J:108758
dehydration J:108758
epidermal desquamation J:108758
postnatal lethality, complete penetrance J:108758
Krt1tm1Tmm/Krt1tm1Tmm
involves: 129 * C57BL/6 		abnormal blood cell morphology/development J:200244
abnormal cerebellar granule layer morphology J:200244
abnormal circulating interleukin level J:200244
abnormal corneocyte envelope morphology J:200244
abnormal interleukin secretion J:200244
abnormal skin morphology J:200244
abnormal vasculogenesis J:200244
impaired skin barrier function J:200244
increased circulating interleukin-18 level J:200244
increased vascular permeability J:200244
neonatal lethality, incomplete penetrance J:200244
weight loss J:200244
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory