Krt8 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Krt8
keratin 8
MGI:96705

28 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Krt8^{tm1b(EUCOMM)Hmgu}/Krt8⁺ C57BL/6N-Krt8^{tm1b(EUCOMM)Hmgu}/Ics	decreased exploration in new environment	J:211773
	improved glucose tolerance	J:211773
	increased neutrophil cell number	J:211773
	increased prepulse inhibition	J:211773
Krt8^{tm1b(EUCOMM)Hmgu}/Krt8^{tm1b(EUCOMM)Hmgu} C57BL/6N-Krt8^{tm1b(EUCOMM)Hmgu}/Ics	preweaning lethality, complete penetrance	J:211773
Krt8^tm1Rgo/Krt8^tm1Rgo involves: 129S2/SvPas * C57BL/6	abnormal extraembryonic tissue physiology	J:121811
	abnormal placenta morphology	J:121811
	abnormal trophoblast giant cell morphology	J:121811
	abnormal trophoblast layer morphology	J:121811
	decreased embryo weight	J:12899
	embryonic lethality during organogenesis, incomplete penetrance	J:12899, J:121811
	extramedullary hematopoiesis	J:12899
	impaired placental function	J:121811
	internal hemorrhage	J:12899
	reduced female fertility	J:12899
Krt8^tm1Rgo/Krt8^tm1Rgo involves: 129S2/SvPas * C57BL/6 * FVB/N	abnormal colon morphology	J:22116, J:89299
	abnormal hepatocyte morphology	J:44938, J:86719, J:106541, J:121813
	abnormal intestinal epithelium morphology	J:118021
	abnormal intestinal mineral absorption	J:89299
	chronic inflammation	J:86719, J:98058
	decreased body weight	J:89299
	diarrhea	J:89299
	embryonic lethality during organogenesis, incomplete penetrance	J:22116
	enlarged spleen	J:22116
	female infertility	J:22116
	hepatic necrosis	J:22116, J:86719
	hepatic steatosis	J:86719
	liver hemorrhage	J:86719
	rectal prolapse	J:22116

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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