Lcat Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lcat
lecithin cholesterol acyltransferase
MGI:96755

28 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lcat^tm1Hgc/Lcat⁺ involves: C57BL/6 * DBA	abnormal circulating protein level	J:41208
Lcat^tm1Hgc/Lcat⁺ involves: C57BL/6 * DBA	decreased circulating cholesterol level	J:41208
Lcat^tm1Hgc/Lcat^tm1Hgc involves: 129 * C57BL/6 * C57BL/6J * SJL	abnormal renal glomerulus morphology	J:93775
	expanded mesangial matrix	J:93775
	increased mesangial cell number	J:93775
Lcat^tm1Hgc/Lcat^tm1Hgc involves: 129P2/OlaHsd * C57BL/6 * DBA	abnormal cholesterol homeostasis	J:75567
	abnormal circulating protein level	J:75567
	abnormal lipid homeostasis	J:75567
	decreased circulating HDL cholesterol level	J:75567
Lcat^tm1Hgc/Lcat^tm1Hgc involves: C57BL/6 * DBA	abnormal adrenal gland morphology	J:41208
	abnormal circulating protein level	J:41208
	abnormal lipid homeostasis	J:41208
	abnormal lipid level	J:41208
	decreased cholesterol level	J:41208
	decreased circulating cholesterol level	J:41208
	decreased circulating HDL cholesterol level	J:41208
	increased cholesterol level	J:41208
Lcat^tm1Nsa/Lcat⁺ B6.Cg-Lcat^tm1Nsa	normal renal/urinary system phenotype	J:69299
Lcat^tm1Nsa/Lcat⁺ involves: 129X1/SvJ * C57BL/6J	abnormal cholesterol homeostasis	J:39237
	abnormal lipid level	J:39237
	decreased circulating cholesterol level	J:39237
	decreased circulating HDL cholesterol level	J:39237
	increased circulating triglyceride level	J:39237
Lcat^tm1Nsa/Lcat^tm1Nsa B6.Cg-Lcat^tm1Nsa	abnormal circulating phospholipid level	J:69299
	abnormal kidney afferent arteriole morphology	J:69299
	abnormal lipid level	J:69299
	abnormal renal glomerulus morphology	J:69299
	decreased circulating cholesterol level	J:69299
	decreased circulating HDL cholesterol level	J:69299
	decreased circulating VLDL cholesterol level	J:69299
	decreased erythrocyte osmotic fragility	J:69299
	expanded mesangial matrix	J:69299
	glomerulosclerosis	J:69299
	normal hematopoietic system phenotype	J:69299
	hemolytic anemia	J:69299
	normal homeostasis/metabolism phenotype	J:69299
	increased circulating triglyceride level	J:69299
	increased mesangial cell number	J:69299
	increased urine protein level	J:69299
	reticulocytosis	J:69299
	normal vision/eye phenotype	J:69299
Lcat^tm1Nsa/Lcat^tm1Nsa involves: 129X1/SvJ * C57BL/6J	abnormal cholesterol homeostasis	J:39237
	abnormal lipid level	J:39237
	decreased circulating cholesterol level	J:39237
	decreased circulating HDL cholesterol level	J:39237
	increased circulating triglyceride level	J:39237
	normal renal/urinary system phenotype	J:39237
	normal vision/eye phenotype	J:39237
Tg(Lcat)1Ssf/Tg(Lcat)1Ssf C57BL/6-Tg(Lcat)1Ssf	increased circulating cholesterol level	J:94077
	increased circulating HDL cholesterol level	J:94077
	increased circulating phospholipid level	J:94077

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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