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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lcat
lecithin cholesterol acyltransferase
MGI:96755
25 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Apoetm1Unc/Apoetm1Unc
Lcattm1Hgc/Lcattm1Hgc
involves: 129P2/OlaHsd * C57BL/6 * DBA 		abnormal cholesterol homeostasis J:75567
abnormal circulating protein level J:75567
abnormal lipid homeostasis J:75567
normal homeostasis/metabolism phenotype J:75567
Lcattm1Hgc/Lcattm1Hgc
Ldlrtm1Her/Ldlrtm1Her
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * DBA 		abnormal cholesterol homeostasis J:75567, J:89015
abnormal circulating protein level J:75567
abnormal lipid homeostasis J:75567, J:89015
decreased circulating glucose level J:89015
decreased circulating HDL cholesterol level J:75567, J:89015
decreased circulating insulin level J:89015
decreased circulating LDL cholesterol level J:89015
decreased lipoprotein lipase activity J:89015
normal homeostasis/metabolism phenotype J:75567
increased circulating cholesterol level J:75567
increased circulating triglyceride level J:75567, J:89015
increased circulating VLDL cholesterol level J:75567, J:89015
Lcattm1Hgc/Lcattm1Hgc
Tg(SREBP1a)7343Reh/?
involves: 129 * C57BL/6 * C57BL/6J * SJL 		abnormal glomerular capillary morphology J:93775
abnormal lipid homeostasis J:93775
abnormal podocyte morphology J:93775
abnormal proximal convoluted tubule morphology J:93775
abnormal renal glomerulus morphology J:93775
abnormal renal tubule morphology J:93775
albuminuria J:93775
decreased circulating HDL cholesterol level J:93775
decreased circulating LDL cholesterol level J:93775
decreased circulating triglyceride level J:93775
enlarged liver J:93775
expanded mesangial matrix J:93775
glomerulosclerosis J:93775
increased circulating cholesterol level J:93775
increased circulating phospholipid level J:93775
increased circulating VLDL cholesterol level J:93775
increased mesangial cell number J:93775
podocyte foot process effacement J:93775
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory