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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lck
lymphocyte protein tyrosine kinase
MGI:96756
43 phenotypes from 10 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lckm1Btlr/Lckm1Btlr
C57BL/6J-Lckm1Btlr 		abnormal CD4-positive T cell differentiation J:144695
abnormal CD8-positive, alpha-beta T cell differentiation J:144695
decreased CD4-positive, alpha-beta T cell number J:144695
decreased CD8-positive, alpha-beta T cell number J:144695
decreased cytotoxic T cell cytolysis J:144695
thymus atrophy J:144695
thymus hypoplasia J:144695
Lckm2Btlr/Lckm2Btlr
C57BL/6J-Lckm2Btlr 		decreased CD4-positive, alpha-beta T cell number J:203759
decreased CD8-positive, alpha-beta T cell number J:203759
decreased IgG level J:203759
Lckm3Btlr/Lckm3Btlr
C57BL/6J-Lckm3Btlr 		abnormal T cell subpopulation ratio J:217863
decreased single-positive T cell number J:217863
increased activated T cell number J:217863
increased single-positive T cell number J:217863
Lcktm1.1Litt/Lcktm1.1Litt
Not Specified 		abnormal immunoglobulin level J:152472
abnormal lymphocyte morphology J:152472
abnormal thymus morphology J:152472
Lcktm1Dbs/Lcktm1Dbs
involves: C3H * C57BL/6 		abnormal CD4-positive, alpha beta T cell morphology J:114660
abnormal CD8-positive, alpha beta T cell morphology J:114660
abnormal double-negative T cell morphology J:114660
abnormal T cell differentiation J:114660
decreased T cell number J:114660
decreased T cell proliferation J:114660
decreased thymocyte number J:114660
Lcktm1Litt/Lcktm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129X1/SvJ 		abnormal regulatory T cell physiology J:152472
decreased regulatory T cell number J:152472
decreased T cell proliferation J:152472
enlarged lymph nodes J:152472
increased regulatory T cell number J:152472
increased T cell number J:152472
Lcktm1Mak/Lcktm1Mak
B6.129S2-Lcktm1Mak 		abnormal intraepithelial T cell morphology J:111646
abnormal intraepithelial T cell number J:111646
abnormal T cell differentiation J:111646
decreased cytotoxic T cell cytolysis J:111646
decreased gamma-delta intraepithelial T cell number J:111646
Lcktm1Mak/Lcktm1Mak
involves: 129S2/SvPas 		abnormal alpha-beta intraepithelial T cell morphology J:112977
abnormal double-negative T cell morphology J:110847
abnormal lymphocyte morphology J:1119
abnormal single-positive T cell number J:37062
abnormal T cell morphology J:110847
abnormal thymocyte activation J:110847
decreased CD4-positive, alpha-beta T cell number J:37940
decreased CD8-positive, alpha-beta T cell number J:37940
decreased double-positive T cell number J:1119, J:110847
decreased gamma-delta intraepithelial T cell number J:37940, J:112977
decreased gamma-delta T cell number J:37062
decreased IgG1 level J:1119
decreased T cell number J:1119, J:37062
decreased thymocyte number J:1119
increased IgG2a level J:1119
increased IgG3 level J:1119
increased IgM level J:1119
thymus atrophy J:1119
thymus hypoplasia J:37062, J:37940
Tg(Lck)4220Rmp/0
involves: C57BL/6J * DBA/2 		decreased tumor-free survival time J:88120
increased T cell derived lymphoma incidence J:88120
Tg(Lck*F505)2964Rmp/?
involves: C57BL/6J * DBA/2 		normal neoplasm J:88309
Tg(Lck*F505)3073Rmp/?
involves: C57BL/6J * DBA/2 		normal neoplasm J:88309
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory