Lcn2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lcn2
lipocalin 2
MGI:96757

53 phenotypes from 4 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lcn2^tm1Aade/Lcn2^tm1Aade B6.129P2-Lcn2^tm1Aade	decreased circulating adiponectin level	J:169355
	hepatic steatosis	J:169355
	impaired adaptive thermogenesis	J:169355
	impaired glucose tolerance	J:169355
	increased brown adipose tissue amount	J:169355
	increased circulating cholesterol level	J:169355
	increased circulating insulin level	J:169355
	increased circulating LDL cholesterol level	J:169355
	increased fasting circulating glucose level	J:169355
	increased fat cell size	J:169355
	increased heart weight	J:169355
	increased kidney weight	J:169355
	increased liver triglyceride level	J:169355
	increased liver weight	J:169355
	increased spleen weight	J:169355
	increased susceptibility to diet-induced obesity	J:169355
	increased white adipose tissue amount	J:169355
	insulin resistance	J:169355
Lcn2^tm1Aade/Lcn2^tm1Aade involves: 129P2/OlaHsd * C57BL/6	increased susceptibility to bacterial infection	J:95107
	increased susceptibility to induced morbidity/mortality	J:95107
	sepsis	J:95107
Lcn2^{tm1b(KOMP)Wtsi}/Lcn2^{tm1b(KOMP)Wtsi} C57BL/6N-Lcn2^{tm1b(KOMP)Wtsi}/J	decreased circulating glucose level	J:211773
	decreased circulating iron level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased thigmotaxis	J:211773
	increased heart weight	J:211773
	increased mean corpuscular volume	J:211773
	increased urine microalbumin level	J:211773
Lcn2^tm1Mak/Lcn2^tm1Mak involves: 129P2/OlaHsd * C57BL/6J	increased susceptibility to bacterial infection	J:106079
	reduced female fertility	J:106079
	normal renal/urinary system phenotype	J:106079
Lcn2^tm1Mrgr/Lcn2^tm1Mrgr 129(B6)-Lcn2^tm1Mrgr	abnormal erythropoiesis	J:173490
	abnormal mast cell physiology	J:173490
	abnormal myelopoiesis	J:173490
	decreased apoptosis	J:173490
	decreased physiological sensitivity to xenobiotic	J:173490
	decreased thymocyte apoptosis	J:173490
	normal hematopoietic system phenotype	J:173490
	increased B cell number	J:173490
	increased bone marrow cell number	J:173490
	increased erythroblast number	J:173490
	increased erythrocyte cell number	J:173490
	increased erythroid progenitor cell number	J:173490
	increased hematocrit	J:173490
	increased leukocyte cell number	J:173490
	increased lymphocyte cell number	J:173490
	increased macrophage cell number	J:173490
	increased mean corpuscular hemoglobin	J:173490
	increased monocyte cell number	J:173490
	increased neutrophil cell number	J:173490
	increased splenocyte number	J:173490
	myeloid hyperplasia	J:173490
	spleen hyperplasia	J:173490
	thrombocytopenia	J:173490
	thymus hyperplasia	J:173490
Lcn2^tm1Mrgr/Lcn2^tm1Mrgr B6.129-Lcn2^tm1Mrgr	abnormal mast cell physiology	J:173490
Lcn2^tm1Mrgr/Lcn2^tm1Mrgr involves: 129 * C57BL/6	abnormal mast cell physiology	J:173490

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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