Lef1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lef1
lymphoid enhancer binding factor 1
MGI:96770

52 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lef1^{tm1.1(KOMP)Vlcg}/Lef1⁺ C57BL/6N-Lef1^{tm1.1(KOMP)Vlcg}/Ucd	decreased prepulse inhibition	J:211773
	increased monocyte cell number	J:211773
Lef1^{tm1.1(KOMP)Vlcg}/Lef1^{tm1.1(KOMP)Vlcg} C57BL/6N-Lef1^{tm1.1(KOMP)Vlcg}/MbpMmucd	abnormal craniofacial morphology	J:211773
Lef1^{tm1.1(KOMP)Vlcg}/Lef1^{tm1.1(KOMP)Vlcg} C57BL/6N-Lef1^{tm1.1(KOMP)Vlcg}/Ucd	preweaning lethality, complete penetrance	J:211773
Lef1^tm1Rug/Lef1^tm1Rug involves: 129S2/SvPas	abnormal hippocampus region morphology	J:59284
Lef1^tm1Rug/Lef1^tm1Rug involves: 129S2/SvPas	absent dentate gyrus	J:59284
Lef1^tm1Rug/Lef1^tm1Rug involves: 129S2/SvPas * C57BL/6	abnormal hair follicle development	J:18378
	abnormal hair follicle morphology	J:18378
	abnormal mammary gland bud morphology	J:18378
	abnormal retina vasculature morphology	J:144980
	abnormal vascular regression	J:144980
	absent alveolar process	J:18378
	absent barrels in primary somatosensory cortex	J:18378
	absent hair follicle melanin granules	J:18378
	absent incisors	J:18378
	absent lower incisors	J:18378
	absent mammary gland	J:18378
	absent mesencephalic trigeminal nucleus	J:18378
	absent molars	J:18378
	absent subcutaneous adipose tissue	J:18378
	absent teeth	J:18378
	absent upper incisors	J:18378
	absent vibrissae	J:18378
	alopecia	J:18378
	arrest of tooth development	J:18378
	decreased body size	J:18378
	decreased hair follicle number	J:18378
	normal immune system phenotype	J:18378
	persistence of hyaloid vascular system	J:101493
	pointed snout	J:18378
	postnatal lethality, complete penetrance	J:18378
	thin skin	J:18378
	underdeveloped hair follicles	J:18378
Lef1^tm1Rug/Lef1^tm1Rug involves: C57BL/6 * ICR	abnormal endometrial gland development	J:189507
Lef1^tm1Rug/Lef1^tm1Rug involves: C57BL/6 * ICR	absent endometrial glands	J:189507
Lef1^tm2Rug/Lef1^tm2Rug involves: 129S2/SvPas	abnormal brain morphology	J:59284
	abnormal hippocampus development	J:59284
	absent dentate gyrus	J:59284
	absent hippocampus	J:59284
Tg(Krt14-dnLef1)LFmw/? involves: C57BL/6 * CBA	abnormal hair follicle orientation	J:73649
	abnormal skin condition	J:73649
	alopecia	J:73649
	epithelioid cyst	J:73649
	increased skin tumor incidence	J:73649
	sparse vibrissae	J:73649
	thick skin	J:73649
Tg(Myh6-Lef1)2Tfo/Y involves: C57BL/6J * FVB/N	perinatal lethality, complete penetrance	J:109612
Tg(Myh6-Lef1)2Tfo/0 involves: C57BL/6J * FVB/N	abnormal myocardial fiber physiology	J:109612
	decreased heart left ventricle posterior wall thickness	J:109612
	decreased heart ventricle muscle contractility	J:109612
	dilated cardiomyopathy	J:109612
	dilated heart left ventricle	J:109612
	dilated heart right ventricle	J:109612
	increased heart rate	J:109612

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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