Lgals3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lgals3
lectin, galactose binding, soluble 3
MGI:96778

80 phenotypes from 3 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lgals3^em1Vari/Lgals3^em1Vari involves: C3H/HeJ * C57BL/6J	decreased bone strength	J:329549
	decreased bone trabecular spacing	J:329549
	normal growth/size/body region phenotype	J:329549
	increased bone mineral density of vertebrae	J:329549
	increased bone trabecula number	J:329549
	increased bone volume	J:329549
	increased compact bone volume	J:329549
	increased internal diameter of femur	J:329549
	increased trabecular bone connectivity density	J:329549
	increased trabecular bone mass	J:329549
	increased trabecular bone thickness	J:329549
	increased trabecular bone volume	J:329549
	increased volumetric bone mineral density	J:329549
	normal skeleton phenotype	J:329549
Lgals3^tm1Ftl/Lgals3^tm1Ftl B6.129S2-Lgals3^tm1Ftl	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	J:109126
	abnormal dendritic cell physiology	J:109126
	abnormal interferon secretion	J:109126
	abnormal response to infection	J:109126
	brain inflammation	J:109126
	decreased macrophage cell number	J:109126
	increased IgG level	J:109126
	increased interleukin-12b secretion	J:109126
	increased susceptibility to parasitic infection	J:109126
	lung inflammation	J:109126
	small intestinal inflammation	J:109126
Lgals3^tm1Ftl/Lgals3^tm1Ftl involves: 129S2/SvPas * C57BL/6	abnormal leukocyte physiology	J:60741
	abnormal macrophage physiology	J:60741
	abnormal monocyte morphology	J:60741
	abnormal seminiferous tubule morphology	J:313172
	abnormal Sertoli cell development	J:313172
	abnormal spermatogenesis	J:313172
	abnormal testis physiology	J:313172
	decreased lymphocyte cell number	J:60741
	decreased macrophage cell number	J:60741, J:313172
	decreased male germ cell number	J:313172
	decreased monocyte cell number	J:60741
	decreased testis weight	J:313172
	increased circulating testosterone level	J:313172
	increased eosinophil cell number	J:60741
	increased macrophage apoptosis	J:60741
	increased male germ cell apoptosis	J:313172
	peritoneal inflammation	J:60741
	testicular atrophy	J:313172
Lgals3^tm1Ftl/Lgals3^tm1Ftl involves: 129S2/SvPas * CD-1	abnormal hepatocyte morphology	J:116073
	abnormal liver morphology	J:116073, J:221030
	focal hepatic necrosis	J:116073, J:221030
	hepatic steatosis	J:116073, J:221030
	increased circulating alanine transaminase level	J:116073
	increased hepatocellular carcinoma incidence	J:221030
	increased liver triglyceride level	J:116073
	increased liver weight	J:116073
	liver fibrosis	J:221030
	liver inflammation	J:221030
	Mallory bodies	J:116073
	oxidative stress	J:116073
Lgals3^tm1Poi/Lgals3^tm1Poi B6.Cg-Lgals3^tm1Poi/J	abnormal circadian behavior	J:264129
	abnormal stationary movement	J:264129
	decreased locomotor activity	J:264129
	increased body weight	J:264129
	increased bone mineral density	J:264129
	increased total body fat amount	J:264129
Lgals3^tm1Poi/Lgals3^tm1Poi involves: 129 * C57BL/6J * SJL	normal integument phenotype	J:47227
	normal mortality/aging	J:47227
	normal reproductive system phenotype	J:47227
Lgals3^tm1Poi/Lgals3^tm1Poi involves: 129/Sv * C57BL/6 * MF1 * SJL	decreased granulocyte number	J:110422
Lgals3^tm1Poi/Lgals3^tm1Poi involves: 129/Sv * C57BL/6 * SJL	abnormal kidney physiology	J:131371
	abnormal long bone epiphyseal plate morphology	J:66902
	abnormal long bone hypertrophic chondrocyte zone	J:66902
	abnormal macrophage physiology	J:131971
	decreased susceptibility to injury	J:131371
	decreased width of hypertrophic chondrocyte zone	J:66902
	impaired macrophage chemotaxis	J:131971
	impaired macrophage phagocytosis	J:131407
	impaired neutrophil recruitment	J:131407
	increased interleukin-6 secretion	J:131407
	increased susceptibility to bacterial infection	J:131407
	increased susceptibility to induced morbidity/mortality	J:131407
	increased tumor necrosis factor secretion	J:131407
	lung inflammation	J:131407
	sepsis	J:131407
Lgals3^tm1Poi/Lgals3^tm1Poi involves: 129S/SvEv	abnormal social/conspecific interaction behavior	J:217719
	aggression towards inanimate objects	J:217719
	impaired cued conditioning behavior	J:217719

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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