Lif Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lif
leukemia inhibitory factor
MGI:96787

68 phenotypes from 3 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lif^tm1Cgre/Lif^tm1Cgre involves: MF1	abnormal macrophage morphology	J:96965
	abnormal uterus morphology	J:96965
	increased eosinophil cell number	J:96965
	increased uterine NK cell number	J:96965
Lif^tm1Phb/Lif⁺ involves: 129S2/SvPas * C57BL/6 * DBA/2	decreased body size	J:77410
	decreased erythroid progenitor cell number	J:77410
	decreased hematopoietic stem cell number	J:77410
	decreased T cell proliferation	J:77410
Lif^tm1Phb/Lif^tm1Phb involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal embryo apposition	J:63668
	abnormal embryo attachment	J:63668
	abnormal uterine receptivity	J:63668
	decreased body size	J:77410
	decreased common myeloid progenitor cell number	J:77410
	decreased erythroid progenitor cell number	J:77410
	decreased hematopoietic stem cell number	J:77410
	decreased T cell proliferation	J:77410
	failure of embryo implantation	J:63668
	female infertility	J:63668, J:77410
	normal hematopoietic system phenotype	J:77410
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv	abnormal involution of the mammary gland	J:83804
	abnormal mammary gland alveolus morphology	J:83804
	abnormal mammary gland duct morphology	J:83804
	abnormal mammary gland growth during pregnancy	J:83804
	abnormal mammary gland physiology	J:83804
	decreased circulating adrenocorticotropin level	J:34269
	decreased motor neuron number	J:103711
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * BALB/c	abnormal hepatocyte morphology	J:136940
	abnormal pilomotor reflex	J:136940
	decreased interleukin-10 secretion	J:136940
	decreased leukocyte cell number	J:136940
	diarrhea	J:136940
	hepatic necrosis	J:136940
	increased circulating alanine transaminase level	J:136940
	increased circulating aspartate transaminase level	J:136940
	increased circulating interleukin-6 level	J:136940
	increased circulating serum amyloid protein level	J:136940
	increased circulating tumor necrosis factor level	J:136940
	increased susceptibility to bacterial infection induced morbidity/mortality	J:136940
	increased susceptibility to endotoxin shock	J:136940
	increased susceptibility to weight loss	J:136940
	liver hemorrhage	J:136940
	liver vascular congestion	J:136940
	thrombocytopenia	J:136940
	tremors	J:136940
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * BALB/c * C57BL/6J	abnormal skeleton morphology	J:82113
	postnatal lethality, incomplete penetrance	J:82113
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * C57BL/6	abnormal astrocyte morphology	J:137720
	abnormal blood vessel morphology	J:137720
	abnormal brain vasculature morphology	J:137720
	abnormal capillary morphology	J:137720
	abnormal CNS glial cell morphology	J:115507
	abnormal glial cell morphology	J:89814
	abnormal induced retina neovascularization	J:137720
	abnormal retina vasculature morphology	J:137720
	abnormal skin vasculature morphology	J:137720
	decreased body size	J:119777
	decreased susceptibility to injury	J:89814, J:137720
	increased acute inflammation	J:119777
	increased circulating interleukin-1 beta level	J:119777
	increased vascular endothelial cell proliferation	J:137720
	normal nervous system phenotype	J:115507
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * C57BL/6 * MF1	decreased circulating triglyceride level	J:87585
	increased circulating insulin-like growth factor I level	J:87585
	increased circulating leptin level	J:87585
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * C57BL/6J	abnormal uterus morphology	J:35071
	decreased body weight	J:35071
	failure of embryo implantation	J:35071
	female infertility	J:35071
	postnatal growth retardation	J:35071
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * MF1	abnormal osteoclast differentiation	J:137646
	abnormal osteoclast morphology	J:137646
	abnormal osteoclast physiology	J:137646
	decreased bone volume	J:137646
	hypoxia	J:137646
	increased bone resorption	J:137646
	increased osteoclast cell number	J:137646

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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