Lif Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lif
leukemia inhibitory factor
MGI:96787

68 phenotypes from 3 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lif^tm1Cgre/Lif^tm1Cgre involves: MF1	abnormal macrophage morphology	J:96965
	abnormal uterus morphology	J:96965
	increased eosinophil cell number	J:96965
	increased uterine NK cell number	J:96965
Lif^tm1Phb/Lif⁺ involves: 129S2/SvPas * C57BL/6 * DBA/2	decreased body size	J:77410
	decreased erythroid progenitor cell number	J:77410
	decreased hematopoietic stem cell number	J:77410
	decreased T cell proliferation	J:77410
Lif^tm1Phb/Lif^tm1Phb involves: 129S2/SvPas * C57BL/6 * DBA/2	abnormal embryo apposition	J:63668
	abnormal embryo attachment	J:63668
	abnormal uterine receptivity	J:63668
	decreased body size	J:77410
	decreased common myeloid progenitor cell number	J:77410
	decreased erythroid progenitor cell number	J:77410
	decreased hematopoietic stem cell number	J:77410
	decreased T cell proliferation	J:77410
	failure of embryo implantation	J:63668
	female infertility	J:63668, J:77410
	normal hematopoietic system phenotype	J:77410
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv	abnormal involution of the mammary gland	J:83804
	abnormal mammary gland alveolus morphology	J:83804
	abnormal mammary gland duct morphology	J:83804
	abnormal mammary gland growth during pregnancy	J:83804
	abnormal mammary gland physiology	J:83804
	decreased circulating adrenocorticotropin level	J:34269
	decreased motor neuron number	J:103711
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * BALB/c	abnormal hepatocyte morphology	J:136940
	abnormal pilomotor reflex	J:136940
	decreased interleukin-10 secretion	J:136940
	decreased leukocyte cell number	J:136940
	diarrhea	J:136940
	hepatic necrosis	J:136940
	increased circulating alanine transaminase level	J:136940
	increased circulating aspartate transaminase level	J:136940
	increased circulating interleukin-6 level	J:136940
	increased circulating serum amyloid protein level	J:136940
	increased circulating tumor necrosis factor level	J:136940
	increased susceptibility to bacterial infection induced morbidity/mortality	J:136940
	increased susceptibility to endotoxin shock	J:136940
	increased susceptibility to weight loss	J:136940
	liver hemorrhage	J:136940
	liver vascular congestion	J:136940
	thrombocytopenia	J:136940
	tremors	J:136940
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * BALB/c * C57BL/6J	abnormal skeleton morphology	J:82113
	postnatal lethality, incomplete penetrance	J:82113
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * C57BL/6	abnormal astrocyte morphology	J:137720
	abnormal blood vessel morphology	J:137720
	abnormal brain vasculature morphology	J:137720
	abnormal capillary morphology	J:137720
	abnormal CNS glial cell morphology	J:115507
	abnormal glial cell morphology	J:89814
	abnormal induced retina neovascularization	J:137720
	abnormal retina vasculature morphology	J:137720
	abnormal skin vasculature morphology	J:137720
	decreased body size	J:119777
	decreased susceptibility to injury	J:89814, J:137720
	increased acute inflammation	J:119777
	increased circulating interleukin-1 beta level	J:119777
	increased vascular endothelial cell proliferation	J:137720
	normal nervous system phenotype	J:115507
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * C57BL/6 * MF1	decreased circulating triglyceride level	J:87585
	increased circulating insulin-like growth factor I level	J:87585
	increased circulating leptin level	J:87585
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * C57BL/6J	abnormal uterus morphology	J:35071
	decreased body weight	J:35071
	failure of embryo implantation	J:35071
	female infertility	J:35071
	postnatal growth retardation	J:35071
Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * MF1	abnormal osteoclast differentiation	J:137646
	abnormal osteoclast morphology	J:137646
	abnormal osteoclast physiology	J:137646
	decreased bone volume	J:137646
	hypoxia	J:137646
	increased bone resorption	J:137646
	increased osteoclast cell number	J:137646

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24