Lif Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lif
leukemia inhibitory factor
MGI:96787

38 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cntf^tm1Mpin/Cntf^tm1Mpin Lif^tm1Phb/Lif^tm1Phb involves: 129S2/SvPas * C57BL/6	abnormal axon extension	J:158286
	increased susceptibility to injury	J:158286
Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif⁺ involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1	increased growth hormone level	J:87585
Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw involves: 129S/SvEv * 129S1/Sv	decreased motor neuron number	J:103711
Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	postnatal lethality	J:82113
Igf1^tm1Arge/Igf1⁺ Lif^tm1Stw/Lif^tm1Stw involves: 129S/SvEv * 129S1/Sv * C57BL/6 * MF1	abnormal white fat cell morphology	J:87585
	decreased body mass index	J:87585
	decreased body weight	J:87585
	decreased gonadal fat pad weight	J:87585
	normal homeostasis/metabolism phenotype	J:87585
	increased circulating insulin-like growth factor I level	J:87585
	increased circulating leptin level	J:87585
	increased growth hormone level	J:87585
	slow postnatal weight gain	J:87585
Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif⁺ involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	delayed bone ossification	J:82113
	postnatal lethality	J:82113
Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif^tm1Stw involves: 129S/SvEv * 129S1/Sv	abnormal cerebellar Purkinje cell layer	J:103711
	decreased motor neuron number	J:103711
Igf1^tm1Arge/Igf1^tm1Arge Lif^tm1Stw/Lif^tm1Stw involves: 129S/SvEv * 129S1/Sv * BALB/c * C57BL/6J * MF1	abnormal keratinocyte morphology	J:82113
	abnormal long bone morphology	J:82113
	abnormal lung morphology	J:82113
	abnormal mitral cell morphology	J:82113
	abnormal olfactory bulb external plexiform layer morphology	J:82113
	abnormal olfactory bulb layer morphology	J:82113
	abnormal olfactory bulb mitral cell layer morphology	J:82113
	abnormal pulmonary alveolus morphology	J:82113
	abnormal skeleton morphology	J:82113
	abnormal type II pneumocyte morphology	J:82113
	absent type I pneumocytes	J:82113
	atelectasis	J:82113
	decreased body size	J:82113
	decreased body weight	J:82113
	decreased bone mineral density	J:82113
	delayed bone ossification	J:82113
	fragile skeleton	J:82113
	increased type II pneumocyte number	J:82113
	muscle hypoplasia	J:82113
	neonatal lethality, complete penetrance	J:82113
	thick pulmonary interalveolar septum	J:82113
	thin epidermis	J:82113
	underdeveloped hair follicles	J:82113
Il6^tm1Kopf/Il6^tm1Kopf Lif^tm1Stw/Lif^tm1Stw involves: 129S1/Sv * 129S2/SvPas * C57BL/6	abnormal glial cell morphology	J:89814
	decreased susceptibility to injury	J:89814

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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