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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lmna
lamin A
MGI:96794
288 phenotypes from 30 alleles in 25 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
LmnaDhe/Lmna+
B6(D2)-LmnaDhe/TyGrsrJ 		abnormal auditory bulla morphology J:188496
abnormal auditory tube morphology J:188496
abnormal bone mineralization J:160175
abnormal cell cycle J:171665
abnormal cell nucleus morphology J:171665
abnormal coat/hair pigmentation J:160175
abnormal coronal suture morphology J:160175
abnormal cranial suture morphology J:160175
abnormal cranium size J:160175
abnormal distortion product otoacoustic emission J:188496
abnormal DNA replication J:171665
abnormal ear morphology J:188496
abnormal ear physiology J:188496
abnormal frontonasal suture morphology J:160175
abnormal lambdoid suture morphology J:160175
abnormal middle ear development J:188496
abnormal middle ear epithelium morphology J:188496
abnormal middle ear morphology J:188496
abnormal mitosis J:171665
abnormal mitotic spindle assembly checkpoint J:171665
abnormal nasopharynx morphology J:188496
abnormal neurocranium morphology J:160175
abnormal nuclear lamina morphology J:160175, J:171665, J:188496
abnormal peritoneal macrophage morphology J:188496
abnormal sagittal suture morphology J:160175
abnormal tympanic membrane morphology J:188496
aneuploidy J:171665
decreased body size J:160175
decreased body weight J:160175
decreased bone mineral content J:160175
decreased bone mineral density J:160175
decreased cranium height J:160175
decreased cranium width J:160175
decreased fibroblast proliferation J:171665
decreased total body fat amount J:160175
exophthalmos J:160175
flaky skin J:160175
impaired hearing J:188496
increased circulating phosphate level J:188496
increased middle ear goblet cell number J:188496
increased or absent threshold for auditory brainstem response J:188496
increased susceptibility to otitis media J:188496
malocclusion J:160175
mandible hypoplasia J:160175
ocular hypotelorism J:160175
premature aging J:160175
reduced female fertility J:160175
rough coat J:160175
shallow orbits J:160175
short ears J:160175
short maxilla J:160175
short snout J:160175
short upper incisors J:160175
small cranium J:160175
sparse hair J:160175
tympanic membrane retraction J:188496
LmnaDhe/LmnaDhe
B6(D2)-LmnaDhe/TyGrsrJ 		abnormal cranium morphology J:160175
abnormal epidermal layer morphology J:160175
abnormal epidermal melanocyte morphology J:160175
abnormal epidermis stratum basale morphology J:160175
abnormal epidermis stratum granulosum morphology J:160175
abnormal hair cycle anagen phase J:160175
abnormal hard palate morphology J:160175
abnormal keratinocyte morphology J:160175
abnormal neurocranium morphology J:160175
abnormal nuclear lamina morphology J:160175
abnormal sagittal suture morphology J:160175
abnormal tail morphology J:160175
abnormal tongue morphology J:160175
alopecia J:160175
decreased bone mineralization J:160175
decreased subcutaneous adipose tissue amount J:160175
epidermal hyperplasia J:160175
orthokeratosis J:160175
premature death J:160175
sebaceous gland hypoplasia J:160175
thick epidermis J:160175
Lmnaem1Fenz/Lmna+
C57BL/6-Lmnaem1Fenz 		abnormal inguinal fat pad morphology J:338760
abnormal respiratory electron transport chain J:338760
normal adipose tissue phenotype J:338760
decreased white adipose tissue mass J:338760
hepatic steatosis J:338760
impaired glucose tolerance J:338760
increased abdominal fat pad weight J:338760
increased body weight J:338760
increased brown adipose tissue mass J:338760
increased circulating alanine transaminase level J:338760
increased circulating alkaline phosphatase level J:338760
increased circulating aspartate transaminase level J:338760
increased circulating cholesterol level J:338760
increased circulating LDL cholesterol level J:338760
increased liver triglyceride level J:338760
increased renal fat pad weight J:338760
insulin resistance J:338760
LmnaGt(S7-1F1)Sor/Lmna+
involves: 129S4/SvJaeSor * C57BL/6 		no abnormal phenotype detected J:221850
LmnaGt(S7-1F1)Sor/LmnaGt(S7-1F1)Sor
involves: 129S4/SvJaeSor * C57BL/6 		abnormal fat cell differentiation J:221850
abnormal gait J:221850
abnormal heart development J:221850
abnormal mitochondrial ATP synthesis coupled electron transport J:221850
abnormal suckling behavior J:221850
normal craniofacial phenotype J:221850
decreased body weight J:221850
decreased circulating carnitine level J:221850
decreased circulating lactate level J:221850
decreased core body temperature J:221850
decreased grip strength J:221850
decreased heart left ventricle weight J:221850
decreased heart rate J:221850
decreased liver glycogen level J:221850
decreased myocardial fiber size J:221850
decreased quadriceps weight J:221850
decreased skeletal muscle fiber diameter J:221850
decreased skeletal muscle fiber size J:221850
decreased subcutaneous adipose tissue amount J:221850
hunched posture J:221850
hypoglycemia J:221850
increased circulating creatine kinase level J:221850
increased circulating ketone body level J:221850
meteorism J:221850
normal mortality/aging J:221850
muscle weakness J:221850
poor grooming J:221850
postnatal growth retardation J:221850
postnatal lethality, complete penetrance J:221850
prolonged P wave J:221850
prolonged RR interval J:221850
normal skeleton phenotype J:221850
Lmnatm1.1Bliu/Lmna+
involves: C57BL/6 * FVB/N 		abnormal vasodilation J:287256
postnatal growth retardation J:287256
premature death J:287256
Lmnatm1.1Bliu/Lmnatm1.1Bliu
involves: C57BL/6 * FVB/N 		abnormal vasodilation J:287256
increased aorta wall thickness J:287256
postnatal growth retardation J:287256
premature death J:287256
weight loss J:287256
Lmnatm1.1Otin/Lmna+
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood homeostasis J:211388
abnormal cell nucleus morphology J:177575, J:177632
abnormal vascular smooth muscle physiology J:211388
calcified aorta J:211388
calcified aortic arch J:211388
calcified thoracic aorta J:211388
decreased circulating glucose level J:177632
increased circulating alkaline phosphatase level J:211388
premature death J:177575, J:177632
weight loss J:177632
Lmnatm1.1Otin/Lmna+
involves: 129P2/OlaHsd * C57BL/6NTac 		premature aging J:261974
Lmnatm1.1Otin/Lmnatm1.1Otin
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood homeostasis J:177632
abnormal bone structure J:177632
abnormal cell nucleus morphology J:177575, J:177632
abnormal cell physiology J:177632
abnormal hair follicle morphology J:177632
calcified aorta J:211388
decreased bone mineral density J:177632
decreased bone trabecula number J:177632
decreased bone volume J:177632
decreased circulating insulin level J:177632
decreased circulating leptin level J:177632
decreased compact bone thickness J:177632
decreased grip strength J:177632
decreased heart rate J:177632
decreased subcutaneous adipose tissue amount J:177632
hypoglycemia J:177632
increased circulating adiponectin level J:177632
increased circulating growth hormone level J:177632
infertility J:177632
lordokyphosis J:177632
postnatal growth retardation J:177632
premature aging J:177632
premature death J:177575, J:177632
prolonged QRS complex duration J:177632
small cranium J:177632
small lower incisors J:177632
small spleen J:177632
small thymus J:177632
vascular smooth muscle hypoplasia J:177632
weight loss J:177632
Lmnatm1.1Otin/Lmnatm1.1Otin
involves: 129P2/OlaHsd * C57BL/6NTac 		abnormal aorta tunica adventitia morphology J:261974
decreased body weight J:261974
decreased heart rate J:261974
decreased subcutaneous adipose tissue amount J:261974
female infertility J:261974
keratoconjunctivitis sicca J:261974
kyphosis J:261974
oligozoospermia J:261974
penis prolapse J:261974
premature death J:261974
reduced male fertility J:261974
Lmnatm1.1Vde/Lmnatm1.1Vde
B6.129(Cg)-Lmnatm1.1Vde 		abnormal muscle tone J:322912
normal behavior/neurological phenotype J:322912
enhanced exercise endurance J:322912
normal nervous system phenotype J:322912
Lmnatm1.1Yxz/Lmnatm1.1Yxz
involves: 129S4/SvJae * C57BL/6 * CD-1 * SJL 		no abnormal phenotype detected J:211369
Lmnatm1.2Yxz/Lmnatm1.2Yxz
involves: 129S * BALB/cJ * C57BL/6 * CD-1 * SJL 		decreased body weight J:211369
decreased skeletal muscle fiber size J:211369
postnatal growth retardation J:211369
postnatal lethality, complete penetrance J:211369
Lmnatm1b(EUCOMM)Wtsi/Lmna+
C57BL/6N-Lmnatm1b(EUCOMM)Wtsi/Ics 		abnormal cornea morphology J:211773
abnormal optic disk morphology J:211773
cornea ulcer J:211773
improved glucose tolerance J:211773
short tibia J:211773
Lmnatm1b(EUCOMM)Wtsi/Lmnatm1b(EUCOMM)Wtsi
C57BL/6N-Lmnatm1b(EUCOMM)Wtsi/Ics 		preweaning lethality, complete penetrance J:211773
Lmnatm1Bliu/Lmnatm1Bliu
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * SJL 		abnormal artery morphology J:287256
abnormal physiological neovascularization J:287256
abnormal vasodilation J:287256
atherosclerotic lesions J:287256
cardiac fibrosis J:287256
decreased bone trabecula number J:287256
decreased capillary density J:287256
decreased cardiac output J:287256
decreased heart left ventricle muscle contractility J:287256
decreased heart rate J:287256
decreased trabecular bone thickness J:287256
decreased trabecular bone volume J:287256
decreased vascular endothelial cell number J:287256
dilated cardiomyopathy J:287256
impaired exercise endurance J:287256
increased aorta wall thickness J:287256
increased bone trabecular spacing J:287256
osteoporosis J:287256
premature aging J:287256
premature death J:287256
weight loss J:287256
Lmnatm1Gbon/Lmna+
involves: 129S2/SvPas * C57BL/6 		no abnormal phenotype detected J:95528
Lmnatm1Gbon/Lmnatm1Gbon
involves: 129S2/SvPas * C57BL/6 		abnormal diaphragm morphology J:95528
abnormal gait J:95528
abnormal gastrocnemius morphology J:95528
abnormal hypaxial muscle morphology J:95528
abnormal impulse conducting system conduction J:95528
abnormal myocardial fiber morphology J:95528
abnormal soleus morphology J:95528
abnormal tibialis anterior morphology J:95528
bradykinesia J:95528
cardiac fibrosis J:95528
decreased body weight J:95528
decreased cardiac muscle contractility J:187399
decreased circulating glucose level J:95528
decreased heart left ventricle muscle contractility J:95528
dilated cardiomyopathy J:187399
dilated heart atrium J:95528
dilated heart left ventricle J:95528, J:187399
dilated heart right ventricle J:95528
dystrophic muscle J:95528
enlarged heart J:95528
hunched posture J:95528
impaired coordination J:95528
increased triglyceride level J:95528
myocardium necrosis J:95528
postnatal growth retardation J:95528
premature death J:95528
progressive muscle weakness J:95528
prolonged PR interval J:95528
prolonged QRS complex duration J:95528
sinoatrial block J:95528
skeletal muscle fibrosis J:95528
tachypnea J:95528
Lmnatm1Lgf/Lmna+
involves: 129P2/OlaHsd * C57BL/6 		abnormal bone mineralization J:113119
abnormal bone structure J:113119
abnormal cell nucleus morphology J:100220, J:141165, J:146099
abnormal cranial suture morphology J:113119
abnormal rib morphology J:113119, J:141165
abnormal zygomatic arch morphology J:113119
normal behavior/neurological phenotype J:113119
decreased abdominal adipose tissue amount J:113119
decreased body weight J:141165, J:146099
decreased bone mineral density J:141165
decreased percent body fat/body weight J:141165
decreased subcutaneous adipose tissue amount J:113119
kyphosis J:113119, J:141165
micrognathia J:113119
premature death J:113119, J:141165, J:146099
rib fractures J:113119, J:141165
weight loss J:113119
Lmnatm1Lgf/Lmnatm1Lgf
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell nucleus morphology J:113119, J:141165
abnormal cranium morphology J:113119
abnormal skeleton morphology J:113119
decreased body size J:113119
decreased bone mineralization J:113119
decreased total body fat amount J:113119
micrognathia J:113119
premature death J:113119
wide cranial sutures J:113119
Lmnatm1Lgf/Lmnatm1Stw
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal skeleton morphology J:113119
premature death J:113119
Lmnatm1Otin/Lmnatm1Otin
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:177632
Lmnatm1Rben/Lmnatm1Rben
involves: 129S1/Sv * 129X1/SvJ 		abnormal chromosomal synapsis J:223056
abnormal double-strand DNA break repair J:223056
abnormal female meiosis J:223056
abnormal meiosis J:223056
abnormal reproductive system morphology J:223056
arrest of male meiosis J:223056
azoospermia J:223056
male infertility J:223056
normal reproductive system phenotype J:223056
small testis J:223056
Lmnatm1Stw/Lmna+
involves: 129S1/Sv 		abnormal cell nucleus morphology J:58702
Lmnatm1Stw/Lmna+
involves: 129S1/Sv * C57BL/6J 		normal adipose tissue phenotype J:75101
increased circulating insulin level J:75101
insulin resistance J:75101
normal liver/biliary system phenotype J:75101
Lmnatm1Stw/Lmnatm1Stw
involves: 129S1/Sv 		abnormal axon morphology J:75378
abnormal cell nucleus morphology J:58702
abnormal gait J:58702
abnormal myelination J:75378
abnormal sciatic nerve morphology J:75378
decreased body weight J:58702
decreased grip strength J:58702
decreased white adipose tissue amount J:58702
dystrophic muscle J:58702
kyphoscoliosis J:58702
muscle degeneration J:58702
postnatal growth retardation J:58702
premature death J:58702
small spleen J:58702
thymus atrophy J:58702
Lmnatm1Stw/Lmnatm1Stw
involves: 129S1/Sv * C57BL/6 		arrest of male meiosis J:88595
azoospermia J:88595
muscle weakness J:95274
postnatal growth retardation J:95274
premature death J:95274
small seminiferous tubules J:88595
small testis J:88595
Lmnatm1Stw/Lmnatm1Stw
involves: 129S1/Sv * C57BL/6J 		decreased circulating glucose level J:75101
decreased circulating triglyceride level J:75101
Lmnatm1Stw/Lmnatm2Lgf
involves: 129S1/Sv * 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:106473
Lmnatm1Stw/Lmnatm7Lgf
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal cell nucleus morphology J:165928
Lmnatm2.1Gbon/Lmna+
involves: 129 * C57BL/6 		abnormal heart echocardiography feature J:198526
abnormal heart morphology J:198526
abnormal sarcomere morphology J:198526
cardiac fibrosis J:198526
cardiac hypertrophy J:198526
cardiac muscle degeneration J:198526
congestive heart failure J:198526
decreased cardiac muscle contractility J:198526
decreased heart rate J:198526
dilated cardiomyopathy J:198526
dilated heart left ventricle J:198526
normal homeostasis/metabolism phenotype J:198526
increased heart atrium size J:198526
normal muscle phenotype J:198526
premature death J:198526
prolonged PR interval J:198526
prolonged QRS complex duration J:198526
pulmonary edema J:198526
Lmnatm2.1Gbon/Lmnatm2.1Gbon
involves: 129 * C57BL/6 		abnormal behavior J:180603
abnormal cell differentiation J:180603
abnormal gait J:180603
abnormal heart development J:180603
abnormal muscle development J:180603
abnormal myocardial fiber morphology J:180603
abnormal urine homeostasis J:180603
centrally nucleated skeletal muscle fibers J:180603
decreased circulating insulin level J:180603
decreased heart weight J:180603
decreased skeletal muscle fiber size J:180603
decreased white adipose tissue amount J:180603
hypoglycemia J:180603
postnatal growth retardation J:180603
postnatal lethality, complete penetrance J:180603
slow postnatal weight gain J:180603
weight loss J:180603
Lmnatm2Lgf/Lmnatm2Lgf
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:106473
Lmnatm2Lgf/Lmnatm7Lgf
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 		abnormal cell nucleus morphology J:165928
Lmnatm2Stw/Lmnatm2Stw
involves: 129S1/Sv 		abnormal cell nucleus morphology J:83382
abnormal esophageal smooth muscle morphology J:83382
abnormal gait J:83382
abnormal heart morphology J:83382
abnormal incisor morphology J:83382
abnormal scapula morphology J:83382
abnormal skin morphology J:83382
abnormal trabecular bone morphology J:83382
absent subcutaneous adipose tissue J:83382
cardiac muscle degeneration J:83382
decreased body height J:83382
decreased bone mineral density J:83382
decreased eccrine gland number J:83382
decreased hair follicle number J:83382
decreased myocardial fiber number J:83382
decreased myocardial fiber size J:83382
decreased sebaceous gland number J:83382
hyperkeratosis J:83382
normal limbs/digits/tail phenotype J:83382
micrognathia J:83382
muscular atrophy J:83382
osteoporosis J:83382
postnatal growth retardation J:83382
premature aging J:83382
premature death J:83382
prominent ears J:83382
pulmonary hypertension J:83382
skeletal muscle degeneration J:83382
small gonad J:83382
small heart J:83382
small xiphoid process J:83382
thin dermal layer J:83382
Lmnatm3Lgf/Lmna+
involves: 129P2/OlaHsd * C57BL/6 		decreased body weight J:141165
decreased percent body fat/body weight J:141165
kyphosis J:141165
premature death J:141165
rib fractures J:141165
normal skeleton phenotype J:141165
Lmnatm3Lgf/Lmnatm3Lgf
involves: 129P2/OlaHsd 		abnormal axial skeleton morphology J:167229
abnormal cell nucleus morphology J:167229
decreased body weight J:167229
decreased bone mineral density J:167229
decreased total body fat amount J:167229
premature death J:167229
rib fractures J:167229
Lmnatm3Lgf/Lmnatm3Lgf
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell nucleus morphology J:141165
decreased abdominal adipose tissue amount J:141165
decreased subcutaneous adipose tissue amount J:141165
premature death J:141165
rib fractures J:141165
weight loss J:141165
Lmnatm3Stw/Lmnatm3Stw
involves: 129S1/Sv * 129S4/SvJaeSor * C57BL 		abnormal myocardial fiber morphology J:100393
cardiac interstitial fibrosis J:100393
cardiac muscle degeneration J:100393
decreased heart left ventricle muscle contractility J:100393
decreased heart rate J:100393
decreased locomotor activity J:100393
dilated cardiomyopathy J:100393
disheveled coat J:100393
myocardial fiber degeneration J:100393
postnatal growth retardation J:100393
premature death J:100393
prolonged PR interval J:100393
thin myocardium J:100393
Lmnatm4Lgf/Lmna+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell nucleus morphology J:146099
decreased body weight J:146099
premature death J:146099
rib fractures J:146099
Lmnatm4Stw/Lmnatm4Stw
Tg(Vil1-cre)997Gum/0
involves: C57BL/6 * C57BL/6J 		no abnormal phenotype detected J:220874
Lmnatm4Stw/Lmnatm4Stw
Tg(Zp3-cre)93Knw/0
involves: C57BL/6J 		abnormal gait J:220874
centrally nucleated skeletal muscle fibers J:220874
decreased body size J:220874
decreased body weight J:220874
decreased skeletal muscle fiber diameter J:220874
dystrophic muscle J:220874
kinked tail J:220874
postnatal growth retardation J:220874
postnatal lethality, complete penetrance J:220874
Lmnatm5Lgf/Lmnatm5Lgf
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell nucleus morphology J:160705
cardiac fibrosis J:160705
decreased body weight J:160705
decreased heart left ventricle muscle contractility J:160705
decreased survivor rate J:160705
dilated cardiomyopathy J:160705
dilated heart left ventricle J:160705
premature death J:160705
normal skeleton phenotype J:160705
Lmnatm6Lgf/Lmnatm6Lgf
involves: 129P2/OlaHsd 		abnormal cell nucleus morphology J:165928
Lmnatm6Lgf/Lmnatm6Lgf
involves: 129P2/OlaHsd * C57BL/6 		decreased body weight J:160705
Lmnatm7Lgf/Lmna+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell nucleus morphology J:165928
Lmnatm7Lgf/Lmnatm7Lgf
involves: 129P2/OlaHsd * C57BL/6 		abnormal cell nucleus morphology J:165928
normal mortality/aging J:165928
normal reproductive system phenotype J:165928
Lmnatm8Lgf/Lmnatm8Lgf
involves: 129P2/OlaHsd 		abnormal cell nucleus morphology J:167229
abnormal heart left ventricle morphology J:167229
normal adipose tissue phenotype J:167229
decreased heart ventricle muscle contractility J:167229
normal growth/size/body region phenotype J:167229
normal mortality/aging J:167229
normal skeleton phenotype J:167229
Lmnatm9Lgf/Lmnatm9Lgf
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:207144
normal mortality/aging J:207144
normal nervous system phenotype J:207144
Lmnatm10Lgf/Lmnatm10Lgf
involves: 129P2/OlaHsd * C57BL/6 		normal behavior/neurological phenotype J:207144
normal mortality/aging J:207144
normal nervous system phenotype J:207144
Lmnatm11Lgf/Lmna+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cholinergic neuron morphology J:220988
abnormal colon morphology J:220988
abnormal enteric neuron morphology J:220988
abnormal esophageal smooth muscle morphology J:220988
abnormal esophageal squamous epithelium morphology J:220988
abnormal interstitial cell of Cajal morphology J:220988
dilated esophagus J:220988
distended cecum J:220988
esophageal achalasia J:220988
normal nervous system phenotype J:220988
premature death J:220988
normal skeleton phenotype J:220988
weight loss J:220988
Lmnatm11Lgf/Lmnatm11Lgf
involves: 129P2/OlaHsd * C57BL/6 		decreased body size J:220988
normal nervous system phenotype J:220988
premature death J:220988
Lmnatm12Lgf/Lmnatm12Lgf
involves: 129P2/OlaHsd * C57BL/6 		abnormal aorta smooth muscle morphology J:234711
abnormal aorta tunica adventitia morphology J:234711
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory