Lmna Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lmna
lamin A
MGI:96794

28 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Apc^Min/Apc⁺ Lmna^tm4Stw/Lmna^tm4Stw Tg(Vil1-cre)997Gum/0 involves: C57BL/6 * C57BL/6J	duodenum polyps	J:220874
	jejunum polyps	J:220874
Lmna^tm1.1Otin/Lmna⁺ Nat10^{tm1a(KOMP)Wtsi}/Nat10⁺ involves: 129P2/OlaHsd * C57BL/6NTac	decreased body weight	J:261974
	kyphosis	J:261974
	premature death	J:261974
Lmna^tm1.1Otin/Lmna^tm1.1Otin Nat10^{tm1a(KOMP)Wtsi}/Nat10⁺ involves: 129P2/OlaHsd * C57BL/6NTac	decreased heart rate	J:261974
	kyphosis	J:261974
	premature death	J:261974
	reduced fertility	J:261974
	normal reproductive system phenotype	J:261974
	normal vision/eye phenotype	J:261974
Lmna^tm1Stw/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129S1/Sv * 129S4/SvJae * C57BL/6	normal cellular phenotype	J:95274
	normal growth/size/body region phenotype	J:95274
	normal muscle phenotype	J:95274
	normal skeleton phenotype	J:95274
Lmna^tm1Stw/Lmna⁺ Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw} involves: 129S1/Sv * C57BL/6	decreased cardiac muscle contractility	J:227485
	dilated cardiomyopathy	J:227485
	dilated heart left ventricle	J:227485
Lmna^tm1Stw/Lmna^tm1Stw Mlip^{tm1.1(cre)Dzw}/Mlip⁺ involves: 129S1/Sv * C57BL/6	premature death	J:227485
Lmna^tm1Stw/Lmna^tm1Stw Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw} involves: 129S1/Sv * C57BL/6	decreased cardiac muscle contractility	J:227485
	dilated heart left ventricle	J:227485
	premature death	J:227485
Lmna^tm1Stw/Lmna^tm1Stw Sln^em1Cyh/Sln^em1Cyh involves: 129S1/Sv * C57BL/6J	decreased body weight	J:284048
	premature death	J:284048
Lmna^tm1Stw/Lmna^tm1Stw Zmpste24^tm1Sgy/Zmpste24⁺ involves: 129S1/Sv * 129S4/SvJae * C57BL/6	muscle weakness	J:95274
	postnatal growth retardation	J:95274
	premature death	J:95274
Lmna^tm1Stw/Lmna^tm1Stw Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129S1/Sv * 129S4/SvJae * C57BL/6	muscle weakness	J:95274
	postnatal growth retardation	J:95274
	premature death	J:95274
Lmna^tm2Lgf/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129S4/SvJae * C57BL/6	normal cellular phenotype	J:106473
	normal growth/size/body region phenotype	J:106473
	normal muscle phenotype	J:106473
	normal skeleton phenotype	J:106473
Lmna^tm6Lgf/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	decreased body weight	J:160705
	decreased survivor rate	J:160705
	premature death	J:160705
Lmna^tm6Lgf/Lmna^tm6Lgf Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129P2/OlaHsd * 129S4/SvJae	normal digestive/alimentary phenotype	J:220988
Lmna^tm6Lgf/Lmna^tm6Lgf Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	decreased body weight	J:160705
	decreased survivor rate	J:160705
	premature death	J:160705
Lmna^tm7Lgf/Lmna⁺ Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	decreased susceptibility to bone fracture	J:165928
	normal growth/size/body region phenotype	J:165928
	normal mortality/aging	J:165928
Lmna^tm10Lgf/Lmna^tm10Lgf Zmpste24^tm1Sgy/Zmpste24^tm1Sgy involves: 129P2/OlaHsd * 129S4/SvJae	abnormal colon morphology	J:220988
	abnormal esophageal squamous epithelium morphology	J:220988
	dilated esophagus	J:220988
	distended cecum	J:220988
	esophageal achalasia	J:220988
	normal nervous system phenotype	J:220988

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24