Lmnb1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lmnb1
lamin B1
MGI:96795

50 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lmnb1^Gt(XA130)Byg/Lmnb1^Gt(XA130)Byg involves: 129P2/OlaHsd * C57BL/6J	abnormal cell differentiation	J:91473
	abnormal cell nucleus morphology	J:91473
	abnormal coronal suture morphology	J:91473
	abnormal cranium morphology	J:91473
	abnormal lung morphology	J:91473
	abnormal sagittal suture morphology	J:91473
	abnormal spine curvature	J:91473
	abnormal thoracic vertebrae morphology	J:91473
	absent pulmonary alveoli	J:91473
	decreased cell proliferation	J:91473
	decreased embryo size	J:91473
	delayed bone ossification	J:91473
	neonatal lethality, complete penetrance	J:91473
	respiratory failure	J:91473
Lmnb1^tm1.1Sgy/Lmnb1^tm1.1Sgy Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	normal mortality/aging	J:174963
Lmnb1^tm1.2Sgy/Lmnb1^tm1.2Sgy involves: 129P2/OlaHsd * FVB/N	abnormal neuron morphology	J:197315
Lmnb1^{tm1a(EUCOMM)Wtsi}/Lmnb1⁺ B6Dnk;B6Brd;B6N-Tyr^c-Brd Lmnb1^{tm1a(EUCOMM)Wtsi}/WtsiH	decreased body weight	J:175295
	decreased circulating alkaline phosphatase level	J:175295
	decreased circulating calcium level	J:175295
	increased mean corpuscular hemoglobin	J:175295
Lmnb1^tm1Yxz/Lmnb1^tm1Yxz involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal neuronal migration	J:178993
	abnormal neuronal precursor proliferation	J:178993
	abnormal phrenic nerve innervation pattern to diaphragm	J:178993
	abnormal pulmonary alveolus morphology	J:178993
	abnormal stratification in cerebral cortex	J:178993
	decreased embryo size	J:178993
	decreased fetal size	J:178993
	microcephaly	J:178993
	neonatal lethality, complete penetrance	J:178993
	respiratory failure	J:178993
	thin diaphragm muscle	J:178993
Lmnb1^tm2Sgy/Lmnb1^tm2Sgy involves: 129P2/OlaHsd * C57BL/6	abnormal cell nucleus morphology	J:197315
	abnormal cranium morphology	J:197315
	abnormal lung development	J:197315
	abnormal neuron morphology	J:197315
	abnormal stratification in cerebral cortex	J:197315
	decreased brain size	J:197315
	decreased midbrain size	J:197315
	flat head	J:197315
	impaired lung alveolus development	J:197315
	neonatal lethality, complete penetrance	J:197315
Tg(Lmnb1)1Yfu/0 involves: C57BL/6J	abnormal myelin sheath morphology	J:197168
	abnormal oligodendrocyte physiology	J:197168
	abnormal spatial learning	J:197168
	abnormal spatial reference memory	J:197168
	abnormal spike wave discharge	J:197168
	axon degeneration	J:197168
	normal behavior/neurological phenotype	J:197168
	clonic seizures	J:197168
	demyelination	J:197168
	hypermyelination	J:197168
	impaired coordination	J:197168
	increased susceptibility to pharmacologically induced seizures	J:197168
	muscle spasm	J:197168
	normal nervous system phenotype	J:197168
	seizures	J:197168
	straub tail	J:197168
	tremors	J:197168

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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