Lmnb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lmnb2
lamin B2
MGI:96796

20 phenotypes from 5 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lmnb2^tm1.1Sgy/Lmnb2^tm1.1Sgy Tg(KRT14-cre)1Cgn/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	normal mortality/aging	J:174963
Lmnb2^{tm1a(KOMP)Wtsi}/Lmnb2⁺ B6JTyr;B6N-Lmnb2^{tm1a(KOMP)Wtsi}/Wtsi	increased circulating creatinine level	J:175295
Lmnb2^tm1Ccof/Lmnb2^tm1Ccof involves: 129P2/OlaHsd * C57BL/6	abnormal cerebellum morphology	J:158610
	abnormal cerebral cortex morphology	J:158610
	abnormal cortical plate morphology	J:158610
	abnormal forebrain morphology	J:158610
	abnormal hippocampus layer morphology	J:158610
	abnormal neuronal migration	J:158610
	abnormal neuronal precursor proliferation	J:158610
	abnormal stratification in cerebral cortex	J:158610
	absent cerebellar foliation	J:158610
	absent Purkinje cell layer	J:158610
	decreased brain size	J:158610
	neonatal lethality, complete penetrance	J:158610
	thin external granule cell layer	J:158610
Lmnb2^tm1Yxz/Lmnb2^tm1Yxz involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	abnormal neuronal migration	J:178993
	abnormal neuronal precursor proliferation	J:178993
	abnormal stratification in cerebral cortex	J:178993
	neonatal lethality, complete penetrance	J:178993
	respiratory failure	J:178993
Lmnb2^tm2Sgy/Lmnb2^tm2Sgy involves: 129P2/OlaHsd * C57BL/6	normal cellular phenotype	J:197315
	normal growth/size/body region phenotype	J:197315
	normal mortality/aging	J:197315
	normal nervous system phenotype	J:197315
	normal reproductive system phenotype	J:197315

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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