Lox Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lox
lysyl oxidase
MGI:96817

52 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lox^b2b370.2Clo/Lox^b2b370.2Clo C57BL/6J-Lox^b2b370.2Clo	abnormal blood vessel morphology	J:175213
	diaphragmatic hernia	J:175213
	heart left ventricle hypertrophy	J:175213
	heart right ventricle hypertrophy	J:175213
	pulmonary artery stenosis	J:175213
	supravalvar aortic stenosis	J:175213
Lox^em1(IMPC)Mbp/Lox⁺ C57BL/6N-Lox^em1(IMPC)Mbp/MbpMmucd	abnormal caudal vertebrae morphology	J:211773
	abnormal kidney morphology	J:211773
	abnormal placenta morphology	J:211773
	abnormal skin morphology	J:211773
	small kidney	J:211773
Lox^em1(IMPC)Mbp/Lox^em1(IMPC)Mbp C57BL/6N-Lox^em1(IMPC)Mbp/MbpMmucd	preweaning lethality, complete penetrance	J:211773
Lox^tm1.1Khki/Lox^tm1.1Khki involves: C57BL/6	decreased tumor latency	J:264295
	increased incidence of tumors by chemical induction	J:264295
	increased lymphocyte cell number	J:264295
	increased susceptibility to induced morbidity/mortality	J:264295
Lox^tm1Ikh/Lox^tm1Ikh involves: 129X1/SvJ * C57BL/6J	abnormal aorta elastic tissue morphology	J:82926
	abnormal aorta smooth muscle morphology	J:82926
	abnormal aorta wall morphology	J:82926
	abnormal blood vessel elastic tissue morphology	J:82926
	abnormal descending thoracic aorta morphology	J:82926
	abnormal diaphragm central tendon morphology	J:82926
	abnormal diaphragm development	J:82926
	aortic aneurysm	J:82926
	decreased aorta elastin content	J:82926
	decreased aorta wall thickness	J:82926
	decreased skin tensile strength	J:82926
	diaphragmatic hernia	J:82926
	hemoperitoneum	J:82926
	hemothorax	J:82926
	perinatal lethality, complete penetrance	J:82926
Lox^tm1Soin/Lox^tm1Soin involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal aorta elastic tissue morphology	J:103389
	abnormal aorta smooth muscle morphology	J:103389
	abnormal blood flow velocity	J:103389
	abnormal bronchiole epithelium morphology	J:101687
	abnormal cutaneous collagen fibril morphology	J:101687
	abnormal cutaneous elastic fiber morphology	J:101687
	abnormal diaphragm morphology	J:101687
	abnormal enzyme/coenzyme activity	J:101687
	abnormal pulmonary acinus morphology	J:101687
	abnormal pulmonary artery morphology	J:101687
	abnormal pulmonary elastic fiber morphology	J:101687
	abnormal suckling behavior	J:103389
	aorta stenosis	J:103389
	aortic aneurysm	J:103389
	atelectasis	J:101687
	cyanosis	J:103389
	decreased locomotor activity	J:103389
	decreased lung weight	J:101687
	diaphragmatic hernia	J:101687
	dilated respiratory conducting tube	J:101687
	emphysema	J:101687
	hemorrhage	J:103389
	impaired branching involved in respiratory bronchiole morphogenesis	J:101687
	impaired branching involved in terminal bronchiole morphogenesis	J:101687
	perinatal lethality, complete penetrance	J:103389
	pulmonary hypoplasia	J:101687
	semilunar valve regurgitation	J:103389

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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