About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tlr4
toll-like receptor 4
MGI:96824
136 phenotypes from 18 alleles in 29 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Tlr4Lps-2Btlr/Tlr4+
C57BL/6J-Tlr4Lps-2Btlr 		decreased interleukin-1 beta secretion J:147339
Tlr4Lps-2Btlr/?
C57BL/6J-Tlr4Lps-2Btlr 		decreased tumor necrosis factor secretion J:147339
Tlr4lps-2J/Tlr4lps-2J
BXD29-Tlr4lps-2J/J 		abnormal inflammatory response J:107391
Tlr4Lps-3Btlr/Tlr4+
C57BL/6J-Tlr4Lps-3Btlr 		decreased interferon-beta secretion J:217295
decreased tumor necrosis factor secretion J:217295
Tlr4Lps-3Btlr/Tlr4Lps-3Btlr
C57BL/6J-Tlr4Lps-3Btlr 		decreased interferon-beta secretion J:217295
decreased tumor necrosis factor secretion J:217295
Tlr4lps-4Btlr/Tlr4+
C57BL/6J-Tlr4lps-4Btlr 		decreased macrophage cytokine production J:224664
decreased tumor necrosis factor secretion J:224664
Tlr4lps-4Btlr/Tlr4lps-4Btlr
C57BL/6J-Tlr4lps-4Btlr 		decreased macrophage apoptosis J:224664
decreased macrophage cytokine production J:224664
decreased tumor necrosis factor secretion J:224664
Tlr4lps-5Btlr/Tlr4lps-5Btlr
C57BL/6J-Tlr4lps-5Btlr 		decreased B cell number J:224666
decreased macrophage cytokine production J:224666
decreased memory B cell number J:224666
decreased tumor necrosis factor secretion J:224666
Tlr4Lps-6Btlr/Tlr4+
C57BL/6J-Tlr4Lps-6Btlr 		decreased macrophage cytokine production J:224667
decreased tumor necrosis factor secretion J:224667
Tlr4Lps-6Btlr/Tlr4Lps-6Btlr
C57BL/6J-Tlr4Lps-6Btlr 		decreased macrophage cytokine production J:224667
decreased tumor necrosis factor secretion J:224667
Tlr4lps-7Btlr/Tlr4+
C57BL/6J-Tlr4Lps-7Btlr 		cellular necrosis J:234239
decreased interleukin-1 beta secretion J:234239
decreased macrophage cytokine production J:234239
decreased tumor necrosis factor secretion J:234239
increased cell death J:234239
Tlr4lps-7Btlr/Tlr4lps-7Btlr
C57BL/6J-Tlr4Lps-7Btlr 		cellular necrosis J:234239
decreased interleukin-1 beta secretion J:234239
decreased macrophage cytokine production J:234239
decreased tumor necrosis factor secretion J:234239
increased cell death J:234239
Tlr4Lps-8Btlr/Tlr4+
C57BL/6J-Tlr4Lps-8Btlr 		cellular necrosis J:234241
decreased interleukin-1 beta secretion J:234241
decreased macrophage cytokine production J:234241
decreased tumor necrosis factor secretion J:234241
increased cell death J:234241
Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
C57BL/6J-Tlr4Lps-8Btlr 		cellular necrosis J:234241
decreased interleukin-1 beta secretion J:234241
decreased macrophage cytokine production J:234241
decreased tumor necrosis factor secretion J:234241
increased cell death J:234241
Tlr4lps-Btlr/Tlr4lps-Btlr
C57BL/6J-Tlr4lps-Btlr 		abnormal macrophage physiology J:128416
Tlr4Lps-d/Tlr4Lps-d
B6.C3-Tlr4Lps-d 		abnormal artery morphology J:101995
abnormal vascular wound healing J:101995
atherosclerotic lesions J:101995
Tlr4Lps-d/Tlr4Lps-d
C3H/HeJ-Tlr4Lps-d 		abnormal circulating glucose level J:126488
abnormal circulating leptin level J:126488
abnormal cytokine level J:96680
abnormal fatty acids level J:126488
abnormal gas homeostasis J:126488
abnormal glucose homeostasis J:126488
abnormal hepatocyte morphology J:135830
abnormal interleukin level J:96680
abnormal lipid level J:126488
abnormal liver physiology J:98036
abnormal locomotor behavior J:122597
abnormal macrophage chemotaxis J:122597
abnormal microglial cell physiology J:99051
abnormal motor coordination/balance J:122597
abnormal muscle cell glucose uptake J:126488
abnormal myelin sheath morphology J:122597
abnormal nervous system morphology J:124100
abnormal phagocyte morphology J:125179
abnormal pulmonary alveolus morphology J:114985
abnormal respiratory system morphology J:114985
abnormal respiratory system physiology J:96680
abnormal spleen weight J:37271
abnormal susceptibility to infection J:162716
abnormal tumor necrosis factor level J:96680
decreased body size J:118467
decreased body temperature J:162716
decreased body weight J:126488
decreased cerebral infarct size J:117223, J:124100
decreased circulating insulin level J:126488
decreased epididymal fat pad weight J:126488
decreased fat cell size J:126488
decreased hepatocyte apoptosis J:135830
decreased liver triglyceride level J:126488
decreased neuron apoptosis J:124100
decreased percent body fat/body weight J:118467
decreased respiratory quotient J:126488
decreased susceptibility to bone fracture J:118467
decreased susceptibility to induced morbidity/mortality J:121930
decreased susceptibility to ischemic brain injury J:117223
decreased susceptibility to weight loss J:162716
dilated pulmonary alveolar duct J:114985
enlarged lung J:114985
focal hepatic necrosis J:135830
normal hematopoietic system phenotype J:135830
normal homeostasis/metabolism phenotype J:135830
normal immune system phenotype J:209808
improved glucose tolerance J:126488
increased adiponectin level J:126488
increased bone mass J:118467
increased bone mineral content J:118467
increased bone mineral density J:118467
increased circulating interleukin-6 level J:37271
increased oxygen consumption J:126488
increased susceptibility to Poxviridae infection induced morbidity/mortality J:162716
liver inflammation J:135830
lung inflammation J:96680
pulmonary edema J:96680
rectal hemorrhage J:37271
Tlr4Lps-d/Tlr4Lps-d
C.C3-Tlr4Lps-d/J 		abnormal bone structure J:118467
decreased angiogenesis J:171028
decreased response of heart to induced stress J:106358
increased bone mass J:118467
increased bone mineral content J:118467
increased bone mineral density J:118467
Tlr4Lps-d/Tlr4Lps-d
involves: C3H/HeJ 		abnormal circulating enzyme level J:114368
abnormal glial cell apoptosis J:99051
abnormal osteoclast differentiation J:131353
abnormal T-helper 2 physiology J:96356
abnormal tumor necrosis factor level J:114368, J:124334
decreased circulating alanine transaminase level J:114368
normal hearing/vestibular/ear phenotype J:168789
hyporesponsive to tactile stimuli J:97819
increased susceptibility to bacterial infection J:5721, J:51522, J:87807
increased susceptibility to induced arthritis J:96356
increased thermal nociceptive threshold J:97819
normal muscle phenotype J:116310
Tlr4lps-del/Tlr4lps-del
C57BL/10ScCr 		abnormal cytokine secretion J:88996
abnormal glial cell physiology J:97819
abnormal macrophage physiology J:88996
decreased response of heart to induced stress J:106358
decreased susceptibility to injury J:97819
hyporesponsive to tactile stimuli J:97819
increased susceptibility to bacterial infection J:51522, J:88996
increased thermal nociceptive threshold J:97819
Tlr4lps-del/Tlr4lps-del
C57BL/10ScN 		abnormal pulmonary alveolar duct morphology J:114985
abnormal pulmonary alveolus morphology J:114985
abnormal retina layer morphology J:141070
abnormal retina pigment epithelium morphology J:141070
abnormal retina progenitor cell morphology J:141070
abnormal retina rod bipolar cell morphology J:141070
abnormal retina rod cell morphology J:141070
decreased percent body fat/body weight J:118467
enlarged lung J:114985
increased bone mass J:118467
increased bone mineral content J:118467
increased spleen weight J:37271
rectal hemorrhage J:37271
Tlr4lps-del/Tlr4lps-del
involves: C57BL/10ScN 		abnormal circulating enzyme level J:114368
abnormal neuron differentiation J:129957
abnormal tumor necrosis factor level J:114368
brain ischemia J:148091
decreased circulating alanine transaminase level J:114368
decreased interleukin-6 secretion J:147023
decreased interleukin-10 secretion J:147023
Tlr4lps-hypo/Tlr4lps-hypo
B6.Cg-Tlr4lps-hypo Cln8mnd 		decreased susceptibility to bacterial infection J:103167
Tlr4lps-n/Tlr4lps-n
C3H/HeN 		decreased acute inflammation J:37271
normal immune system phenotype J:5557
increased spleen weight J:37271
Tlr4tm1.1(KOMP)Vlcg/Tlr4tm1.1(KOMP)Vlcg
C57BL/6N-Tlr4tm1.1(KOMP)Vlcg/Ucd 		abnormal cecum morphology J:211773
abnormal uterus morphology J:211773
enlarged cecum J:211773
enlarged uterus J:211773
Tlr4tm1.1Djh/Tlr4tm1.1Djh
involves: C57BL/6 * FVB/N * SJL 		abnormal bile salt level J:193668
abnormal enterocyte differentiation J:193668
abnormal intestinal goblet cell morphology J:193668
decreased susceptibility to injury J:193668
Tlr4tm1.1Djh/Tlr4tm1.1Djh
involves: FVB/N 		abnormal enterocyte proliferation J:192520
abnormal fibroblast proliferation J:192520
decreased susceptibility to endotoxin shock J:192520
Tlr4tm1.1Karp/Tlr4tm1.1Karp
B6(Cg)-Tlr4tm1.1Karp 		no abnormal phenotype detected J:101977
Tlr4tm1Aki/Tlr4lps-2J
involves: 129P2/OlaHsd * C57BL/6 * DBA/2J 		abnormal inflammatory response J:107391
Tlr4tm1Aki/Tlr4tm1Aki
B6.129P2-Tlr4tm1Aki 		abnormal airway responsiveness J:147534
abnormal nephron morphology J:143920
abnormal proximal convoluted tubule brush border morphology J:143920
abnormal pulmonary alveolar duct morphology J:114985
abnormal pulmonary alveolus morphology J:114985
abnormal pulmonary elastic fiber morphology J:114985
abnormal renal tubule epithelium morphology J:143920
abnormal renal tubule morphology J:143920
abnormal respiratory system morphology J:114985
abnormal respiratory system physiology J:147534
decreased incidence of tumors by chemical induction J:135620
decreased susceptibility to induced morbidity/mortality J:121930
decreased susceptibility to kidney reperfusion injury J:143920
normal digestive/alimentary phenotype J:135620
dilated renal tubule J:143920
enlarged lung J:114985
increased lung compliance J:114985
renal cast J:143920
renal tubular necrosis J:143920
normal respiratory system phenotype J:114985
Tlr4tm1Aki/Tlr4tm1Aki
C.129P2-Tlr4tm1Aki 		decreased susceptibility to induced arthritis J:178054
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd 		decreased circulating interleukin-6 level J:145306
decreased susceptibility to injury J:145306
decreased susceptibility to Orthomyxoviridae infection J:145306
increased susceptibility to bacterial infection J:53519
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal level of surface class II molecules J:76115
abnormal macrophage physiology J:76115
decreased B cell proliferation J:76115
decreased incidence of tumors by chemical induction J:162097
decreased interleukin-6 secretion J:76115
decreased susceptibility to endotoxin shock J:76115
decreased tumor necrosis factor secretion J:76115
normal hearing/vestibular/ear phenotype J:168789
increased susceptibility to bacterial infection J:111778
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd * C57BL/6J 		abnormal acute inflammation J:98224
decreased hemoglobin content J:98224
enlarged mesenteric lymph nodes J:98224
impaired neutrophil chemotaxis J:98224
increased susceptibility to bacterial infection J:98224
Tlr4tm1Djh/Tlr4tm1Djh
Tg(Vil1-cre)997Gum/0
involves: C57BL/6 * C57BL/6J * FVB/N * SJL 		abnormal bile salt level J:193668
abnormal intestinal goblet cell morphology J:193668
decreased susceptibility to injury J:193668
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory