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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tlr4
toll-like receptor 4
MGI:96824
136 phenotypes from 18 alleles in 29 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Tlr4Lps-2Btlr/Tlr4+
C57BL/6J-Tlr4Lps-2Btlr 		decreased interleukin-1 beta secretion J:147339
Tlr4Lps-2Btlr/?
C57BL/6J-Tlr4Lps-2Btlr 		decreased tumor necrosis factor secretion J:147339
Tlr4lps-2J/Tlr4lps-2J
BXD29-Tlr4lps-2J/J 		abnormal inflammatory response J:107391
Tlr4Lps-3Btlr/Tlr4+
C57BL/6J-Tlr4Lps-3Btlr 		decreased interferon-beta secretion J:217295
decreased tumor necrosis factor secretion J:217295
Tlr4Lps-3Btlr/Tlr4Lps-3Btlr
C57BL/6J-Tlr4Lps-3Btlr 		decreased interferon-beta secretion J:217295
decreased tumor necrosis factor secretion J:217295
Tlr4lps-4Btlr/Tlr4+
C57BL/6J-Tlr4lps-4Btlr 		decreased macrophage cytokine production J:224664
decreased tumor necrosis factor secretion J:224664
Tlr4lps-4Btlr/Tlr4lps-4Btlr
C57BL/6J-Tlr4lps-4Btlr 		decreased macrophage apoptosis J:224664
decreased macrophage cytokine production J:224664
decreased tumor necrosis factor secretion J:224664
Tlr4lps-5Btlr/Tlr4lps-5Btlr
C57BL/6J-Tlr4lps-5Btlr 		decreased B cell number J:224666
decreased macrophage cytokine production J:224666
decreased memory B cell number J:224666
decreased tumor necrosis factor secretion J:224666
Tlr4Lps-6Btlr/Tlr4+
C57BL/6J-Tlr4Lps-6Btlr 		decreased macrophage cytokine production J:224667
decreased tumor necrosis factor secretion J:224667
Tlr4Lps-6Btlr/Tlr4Lps-6Btlr
C57BL/6J-Tlr4Lps-6Btlr 		decreased macrophage cytokine production J:224667
decreased tumor necrosis factor secretion J:224667
Tlr4lps-7Btlr/Tlr4+
C57BL/6J-Tlr4Lps-7Btlr 		cellular necrosis J:234239
decreased interleukin-1 beta secretion J:234239
decreased macrophage cytokine production J:234239
decreased tumor necrosis factor secretion J:234239
increased cell death J:234239
Tlr4lps-7Btlr/Tlr4lps-7Btlr
C57BL/6J-Tlr4Lps-7Btlr 		cellular necrosis J:234239
decreased interleukin-1 beta secretion J:234239
decreased macrophage cytokine production J:234239
decreased tumor necrosis factor secretion J:234239
increased cell death J:234239
Tlr4Lps-8Btlr/Tlr4+
C57BL/6J-Tlr4Lps-8Btlr 		cellular necrosis J:234241
decreased interleukin-1 beta secretion J:234241
decreased macrophage cytokine production J:234241
decreased tumor necrosis factor secretion J:234241
increased cell death J:234241
Tlr4Lps-8Btlr/Tlr4Lps-8Btlr
C57BL/6J-Tlr4Lps-8Btlr 		cellular necrosis J:234241
decreased interleukin-1 beta secretion J:234241
decreased macrophage cytokine production J:234241
decreased tumor necrosis factor secretion J:234241
increased cell death J:234241
Tlr4lps-Btlr/Tlr4lps-Btlr
C57BL/6J-Tlr4lps-Btlr 		abnormal macrophage physiology J:128416
Tlr4Lps-d/Tlr4Lps-d
B6.C3-Tlr4Lps-d 		abnormal artery morphology J:101995
abnormal vascular wound healing J:101995
atherosclerotic lesions J:101995
Tlr4Lps-d/Tlr4Lps-d
C3H/HeJ-Tlr4Lps-d 		abnormal circulating glucose level J:126488
abnormal circulating leptin level J:126488
abnormal cytokine level J:96680
abnormal fatty acids level J:126488
abnormal gas homeostasis J:126488
abnormal glucose homeostasis J:126488
abnormal hepatocyte morphology J:135830
abnormal interleukin level J:96680
abnormal lipid level J:126488
abnormal liver physiology J:98036
abnormal locomotor behavior J:122597
abnormal macrophage chemotaxis J:122597
abnormal microglial cell physiology J:99051
abnormal motor coordination/balance J:122597
abnormal myelin sheath morphology J:122597
abnormal nervous system morphology J:124100
abnormal phagocyte morphology J:125179
abnormal pulmonary alveolus morphology J:114985
abnormal respiratory system morphology J:114985
abnormal respiratory system physiology J:96680
abnormal skeletal muscle cell glucose uptake J:126488
abnormal spleen weight J:37271
abnormal susceptibility to infection J:162716
abnormal tumor necrosis factor level J:96680
decreased body size J:118467
decreased body temperature J:162716
decreased body weight J:126488
decreased cerebral infarct size J:117223, J:124100
decreased circulating insulin level J:126488
decreased epididymal fat pad weight J:126488
decreased fat cell size J:126488
decreased hepatocyte apoptosis J:135830
decreased liver triglyceride level J:126488
decreased neuron apoptosis J:124100
decreased percent body fat/body weight J:118467
decreased respiratory quotient J:126488
decreased susceptibility to bone fracture J:118467
decreased susceptibility to induced morbidity/mortality J:121930
decreased susceptibility to ischemic brain injury J:117223
decreased susceptibility to weight loss J:162716
dilated pulmonary alveolar duct J:114985
enlarged lung J:114985
focal hepatic necrosis J:135830
normal hematopoietic system phenotype J:135830
normal homeostasis/metabolism phenotype J:135830
normal immune system phenotype J:209808
improved glucose tolerance J:126488
increased adiponectin level J:126488
increased bone mass J:118467
increased bone mineral content J:118467
increased bone mineral density J:118467
increased circulating interleukin-6 level J:37271
increased oxygen consumption J:126488
increased susceptibility to Poxviridae infection induced morbidity/mortality J:162716
liver inflammation J:135830
lung inflammation J:96680
pulmonary edema J:96680
rectal hemorrhage J:37271
Tlr4Lps-d/Tlr4Lps-d
C.C3-Tlr4Lps-d/J 		abnormal bone structure J:118467
decreased angiogenesis J:171028
decreased response of heart to induced stress J:106358
increased bone mass J:118467
increased bone mineral content J:118467
increased bone mineral density J:118467
Tlr4Lps-d/Tlr4Lps-d
involves: C3H/HeJ 		abnormal circulating enzyme level J:114368
abnormal glial cell apoptosis J:99051
abnormal osteoclast differentiation J:131353
abnormal T-helper 2 physiology J:96356
abnormal tumor necrosis factor level J:114368, J:124334
decreased circulating alanine transaminase level J:114368
normal hearing/vestibular/ear phenotype J:168789
hyporesponsive to tactile stimuli J:97819
increased susceptibility to bacterial infection J:5721, J:51522, J:87807
increased susceptibility to induced arthritis J:96356
increased thermal nociceptive threshold J:97819
normal muscle phenotype J:116310
Tlr4lps-del/Tlr4lps-del
C57BL/10ScCr 		abnormal cytokine secretion J:88996
abnormal glial cell physiology J:97819
abnormal macrophage physiology J:88996
decreased response of heart to induced stress J:106358
decreased susceptibility to injury J:97819
hyporesponsive to tactile stimuli J:97819
increased susceptibility to bacterial infection J:51522, J:88996
increased thermal nociceptive threshold J:97819
Tlr4lps-del/Tlr4lps-del
C57BL/10ScN 		abnormal pulmonary alveolar duct morphology J:114985
abnormal pulmonary alveolus morphology J:114985
abnormal retina layer morphology J:141070
abnormal retina pigment epithelium morphology J:141070
abnormal retina progenitor cell morphology J:141070
abnormal retina rod bipolar cell morphology J:141070
abnormal retina rod cell morphology J:141070
decreased percent body fat/body weight J:118467
enlarged lung J:114985
increased bone mass J:118467
increased bone mineral content J:118467
increased spleen weight J:37271
rectal hemorrhage J:37271
Tlr4lps-del/Tlr4lps-del
involves: C57BL/10ScN 		abnormal circulating enzyme level J:114368
abnormal neuron differentiation J:129957
abnormal tumor necrosis factor level J:114368
brain ischemia J:148091
decreased circulating alanine transaminase level J:114368
decreased interleukin-6 secretion J:147023
decreased interleukin-10 secretion J:147023
Tlr4lps-hypo/Tlr4lps-hypo
B6.Cg-Tlr4lps-hypo Cln8mnd 		decreased susceptibility to bacterial infection J:103167
Tlr4lps-n/Tlr4lps-n
C3H/HeN 		decreased acute inflammation J:37271
normal immune system phenotype J:5557
increased spleen weight J:37271
Tlr4tm1.1(KOMP)Vlcg/Tlr4tm1.1(KOMP)Vlcg
C57BL/6N-Tlr4tm1.1(KOMP)Vlcg/Ucd 		abnormal cecum morphology J:211773
abnormal uterus morphology J:211773
enlarged cecum J:211773
enlarged uterus J:211773
Tlr4tm1.1Djh/Tlr4tm1.1Djh
involves: C57BL/6 * FVB/N * SJL 		abnormal bile salt level J:193668
abnormal enterocyte differentiation J:193668
abnormal intestinal goblet cell morphology J:193668
decreased susceptibility to injury J:193668
Tlr4tm1.1Djh/Tlr4tm1.1Djh
involves: FVB/N 		abnormal enterocyte proliferation J:192520
abnormal fibroblast proliferation J:192520
decreased susceptibility to endotoxin shock J:192520
Tlr4tm1.1Karp/Tlr4tm1.1Karp
B6(Cg)-Tlr4tm1.1Karp 		no abnormal phenotype detected J:101977
Tlr4tm1Aki/Tlr4lps-2J
involves: 129P2/OlaHsd * C57BL/6 * DBA/2J 		abnormal inflammatory response J:107391
Tlr4tm1Aki/Tlr4tm1Aki
B6.129P2-Tlr4tm1Aki 		abnormal airway responsiveness J:147534
abnormal nephron morphology J:143920
abnormal proximal convoluted tubule brush border morphology J:143920
abnormal pulmonary alveolar duct morphology J:114985
abnormal pulmonary alveolus morphology J:114985
abnormal pulmonary elastic fiber morphology J:114985
abnormal renal tubule epithelium morphology J:143920
abnormal renal tubule morphology J:143920
abnormal respiratory system morphology J:114985
abnormal respiratory system physiology J:147534
decreased incidence of tumors by chemical induction J:135620
decreased susceptibility to induced morbidity/mortality J:121930
decreased susceptibility to kidney reperfusion injury J:143920
normal digestive/alimentary phenotype J:135620
dilated renal tubule J:143920
enlarged lung J:114985
increased lung compliance J:114985
renal cast J:143920
renal tubular necrosis J:143920
normal respiratory system phenotype J:114985
Tlr4tm1Aki/Tlr4tm1Aki
C.129P2-Tlr4tm1Aki 		decreased susceptibility to induced arthritis J:178054
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd 		decreased circulating interleukin-6 level J:145306
decreased susceptibility to injury J:145306
decreased susceptibility to Orthomyxoviridae infection J:145306
increased susceptibility to bacterial infection J:53519
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd * C57BL/6 		abnormal level of surface class II molecules J:76115
abnormal macrophage physiology J:76115
decreased B cell proliferation J:76115
decreased incidence of tumors by chemical induction J:162097
decreased interleukin-6 secretion J:76115
decreased susceptibility to endotoxin shock J:76115
decreased tumor necrosis factor secretion J:76115
normal hearing/vestibular/ear phenotype J:168789
increased susceptibility to bacterial infection J:111778
Tlr4tm1Aki/Tlr4tm1Aki
involves: 129P2/OlaHsd * C57BL/6J 		abnormal acute inflammation J:98224
decreased hemoglobin content J:98224
enlarged mesenteric lymph nodes J:98224
impaired neutrophil chemotaxis J:98224
increased susceptibility to bacterial infection J:98224
Tlr4tm1Djh/Tlr4tm1Djh
Tg(Vil1-cre)997Gum/0
involves: C57BL/6 * C57BL/6J * FVB/N * SJL 		abnormal bile salt level J:193668
abnormal intestinal goblet cell morphology J:193668
decreased susceptibility to injury J:193668
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory