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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Lrp1
low density lipoprotein receptor-related protein 1
MGI:96828
113 phenotypes from 10 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Lrp1b2b1554Clo/Lrp1b2b1554Clo
C57BL/6J-Lrp1b2b1554Clo 		abnormal body wall morphology J:175213
abnormal heart ventricle outflow tract morphology J:175213
atrioventricular septal defect J:175213
diaphragmatic hernia J:175213
herniated abdominal wall J:175213
omphalocele J:175213
Lrp1tm1.1(KOMP)Wtsi/Lrp1+
C57BL/6N-Lrp1tm1.1(KOMP)Wtsi/J 		abnormal lens morphology J:211773
increased circulating alkaline phosphatase level J:211773
increased heart weight J:211773
Lrp1tm1.1(KOMP)Wtsi/Lrp1tm1.1(KOMP)Wtsi
C57BL/6N-Lrp1tm1.1(KOMP)Wtsi/J 		abnormal craniofacial morphology J:211773
abnormal embryo size J:211773
abnormal forebrain morphology J:211773
abnormal limb bud morphology J:211773
hemorrhage J:211773
microphthalmia J:211773
preweaning lethality, complete penetrance J:211773
Lrp1tm1Ajmr/Lrp1tm1Ajmr
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:144146
Lrp1tm1Her/Lrp1tm1Her
involves: 129S7/SvEvBrd 		embryonic growth retardation J:30077
embryonic lethality during organogenesis, complete penetrance J:30077
internal hemorrhage J:30077
Lrp1tm2Ajmr/Lrp1tm2Ajmr
involves: 129P2/OlaHsd * C57BL/6 		abnormal liver morphology J:144146
Lrp1tm2Her/Lrp1tm2Her
involves: 129S7/SvEvBrd 		abnormal liver physiology J:76281
normal homeostasis/metabolism phenotype J:67929
Lrp1tm2Her/Lrp1tm2Her
Tg(Camk2a-cre)T29-1Stl/0
involves: 129S7/SvEvBrd * BALB/c * C57BL 		abnormal associative learning J:167724
abnormal lipid level J:167724
abnormal motor capabilities/coordination/movement J:167724
abnormal nervous system physiology J:167724
abnormal synapse morphology J:167724
brain inflammation J:167724
decreased brain cholesterol level J:167724
decreased dendritic spine density J:167724
decreased triglyceride level J:167724
hyperactivity J:167724
impaired contextual conditioning behavior J:167724
impaired coordination J:167724
impaired cued conditioning behavior J:167724
limb grasping J:167724
neurodegeneration J:167724
reduced long-term potentiation J:167724
Lrp1tm2Her/Lrp1tm2Her
Tg(Fabp4-cre)1Rev/0
involves: 129S7/SvEvBrd * C57BL/6 		abnormal adipose tissue amount J:127398
abnormal adipose tissue physiology J:127398
abnormal body temperature homeostasis J:127398
abnormal brown fat cell morphology J:127398
abnormal circulating lipid level J:127398
abnormal fat pad morphology J:127398
abnormal glucose homeostasis J:127398
abnormal lipid homeostasis J:127398
decreased body surface temperature J:127398
decreased body weight J:127398
decreased brown adipose tissue amount J:127398
decreased brown fat cell size J:127398
decreased brown fat lipid droplet number J:127398
decreased circulating free fatty acids level J:127398
decreased circulating glucose level J:127398
decreased circulating insulin level J:127398
decreased circulating leptin level J:127398
decreased epididymal fat pad weight J:127398
decreased interscapular fat pad weight J:127398
decreased liver triglyceride level J:127398
decreased susceptibility to diet-induced obesity J:127398
decreased total body fat amount J:127398
decreased white fat cell size J:127398
normal homeostasis/metabolism phenotype J:127398
impaired adaptive thermogenesis J:127398
improved glucose tolerance J:127398
increased energy expenditure J:127398
increased food intake J:127398
increased oxygen consumption J:127398
increased skeletal muscle cell glucose uptake J:127398
increased susceptibility to weight loss J:127398
trunk curl J:127398
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal circulating protein level J:117317
increased circulating factor VIII level J:117317
increased circulating von Willebrand factor level J:117317
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL 		abnormal blood homeostasis J:83443
abnormal liver physiology J:83443
increased circulating factor VIII level J:83443
increased circulating von Willebrand factor level J:83443
Lrp1tm2Her/Lrp1tm2Her
Tg(Syn1-cre)671Jxm/0
involves: 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal gait J:93329
abnormal limb posture J:93329
abnormal posture J:93329
decreased circulating insulin level J:93329
decreased total body fat amount J:93329
hyperactivity J:93329
hypoglycemia J:93329
impaired limb coordination J:93329
increased food intake J:93329
kyphosis J:93329
limb grasping J:93329
normal nervous system phenotype J:93329
postnatal growth retardation J:93329
premature death J:93329
reduced fertility J:93329
tremors J:93329
weakness J:93329
Lrp1tm2Her/Lrp1tm2Her
Tg(Tagln-cre)1Her/0
B6.Cg-Lrp1tm2Her Tg(Tagln-cre)1Her 		abnormal aorta elastic tissue morphology J:167799
abnormal aorta smooth muscle morphology J:167799
abnormal aorta tunica media morphology J:167799
abnormal vascular smooth muscle physiology J:167799
abnormal vascular wound healing J:167799
decreased vasoconstriction J:167799
Lrp1tm2Her/Lrp1tm2Her
Tg(Tagln-cre)1Her/0
involves: 129S7/SvEvBrd * C57BL/6 * SJL 		abnormal ascending aorta morphology J:209752
abnormal coronary artery morphology J:209752
abnormal heart echocardiography feature J:209752
abnormal myocardial fiber morphology J:209752
aortic valve regurgitation J:209752
cardiac interstitial fibrosis J:209752
decreased cardiac muscle contractility J:209752
decreased systemic arterial diastolic blood pressure J:209752
dilated aorta bulb J:209752
dilated ascending aorta J:209752
dilated cardiomyopathy J:209752
dilated heart left ventricle J:209752
enlarged heart J:209752
increased heart left ventricle size J:209752
increased heart weight J:209752
increased pulse pressure J:209752
perivascular fibrosis J:209752
Lrp1tm3Ajmr/Lrp1tm3Ajmr
involves: 129P2/OlaHsd * C57BL/6 		abnormal liver perisinusoidal space morphology J:144146
decreased hepatocyte number J:144146
lethality throughout fetal growth and development, incomplete penetrance J:144146
liver degeneration J:144146
perinatal lethality, complete penetrance J:144146
Lrp1tm4Ajmr/Lrp1tm4Ajmr
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:144146
Lrp1tm5Ajmr/Lrp1tm5Ajmr
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:186908
Lrp1tm6Ajmr/Lrp1tm6Ajmr
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:186908
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory