Blnk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Blnk
B cell linker
MGI:96878

44 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Blnk^em1(IMPC)H/Blnk^em1(IMPC)H C57BL/6N-Blnk^em1(IMPC)H/H	decreased basophil cell number	J:211773
	decreased leukocyte cell number	J:211773
	decreased lymphocyte cell number	J:211773
	decreased spleen weight	J:211773
	increased eosinophil cell number	J:211773
	increased neutrophil cell number	J:211773
	small spleen	J:211773
Blnk^m1Btlr/Blnk^m1Btlr C57BL/6J-Blnk^m1Btlr	arrested B cell differentiation	J:159439
	decreased IgG level	J:159439
	decreased IgM level	J:159439
	decreased mature B cell number	J:159439
	increased CD4-positive, alpha-beta T cell number	J:159439
	increased CD8-positive, alpha-beta T cell number	J:159439
Blnk^m1Btlr/Blnk^m1Btlr involves: C57BL/6J	arrested B cell differentiation	J:185495
	decreased IgM level	J:185495
	normal immune system phenotype	J:185495
Blnk^tm1Achn/Blnk⁺ involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6	decreased B cell proliferation	J:82430
Blnk^tm1Achn/Blnk^tm1Achn involves: 129X1/SvJ	abnormal B cell differentiation	J:58805
	abnormal mature B cell morphology	J:58805
	absent B-1b cells	J:58805
	arrested B cell differentiation	J:58805
	normal cardiovascular system phenotype	J:58805
	decreased B-1a cell number	J:58805
	decreased immunoglobulin level	J:58805
	decreased mature B cell number	J:58805
	decreased splenocyte number	J:58805
	increased pro-B cell number	J:58805
Blnk^tm1Dkit/Blnk^tm1Dkit involves: C57BL/6	abnormal B cell apoptosis	J:143854
	abnormal B cell differentiation	J:84040
	abnormal immature B cell morphology	J:94297
	abnormal plasma cell differentiation	J:143854
	abnormal pre-B cell morphology	J:84040
	arrested B cell differentiation	J:143854
	decreased follicular B cell number	J:143854
	decreased IgG3 level	J:143854
	decreased IgM level	J:143854
	decreased immature B cell number	J:84040
	decreased marginal zone B cell number	J:143854
	decreased mature B cell number	J:84040
	decreased transitional stage B cell number	J:143854
	increased anti-double stranded DNA antibody level	J:94297
	increased B cell apoptosis	J:143854
	increased leukemia incidence	J:84040
Blnk^tm1Kplm/Blnk^tm1Kplm involves: 129P2/OlaHsd	abnormal B cell activation	J:61130, J:131161
	abnormal B cell differentiation	J:61130, J:131161
	absent B-1a cells	J:61130
	decreased B cell number	J:61130, J:131161
	decreased B cell proliferation	J:61130
	decreased immature B cell number	J:61130
	decreased mature B cell number	J:61130
	decreased pre-B cell number	J:61130, J:120460
	increased B cell apoptosis	J:131161
	increased pro-B cell number	J:61130, J:131161
	spleen hypoplasia	J:131161
Blnk^tm1Pjln/Blnk^tm1Pjln involves: BALB/c	abnormal pre-B cell morphology	J:58740
	arrested B cell differentiation	J:58740
	decreased IgG3 level	J:58740
	decreased IgM level	J:58740
	decreased mature B cell number	J:58740
	enlarged spleen	J:80332
	increased mature B cell number	J:157575
	increased pre-B cell number	J:58740, J:80332
	increased tumor incidence	J:80332

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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