Lyn Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lyn
LYN proto-oncogene, Src family tyrosine kinase
MGI:96892

45 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Blk^tm1Tara/Blk^tm1Tara Fyn^tm1Sor/Fyn^tm1Sor Lyn^tm1Ard/Lyn^tm1Ard either: B6.129-Lyn^tm1Ard Fyn^tm1Sor Blk^tm1Tara or (involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6)	abnormal B cell differentiation	J:115080
	abnormal pro-B cell differentiation	J:115080
	arrested B cell differentiation	J:115080
	decreased B cell number	J:115080
	decreased immature B cell number	J:115080
	decreased pre-B cell number	J:115080
Cd19^tm1Tft/Cd19^tm1Tft Lyn^tm1Sor/Lyn^tm1Sor involves: 129S4/SvJaeSor * C57BL/6	abnormal humoral immune response	J:71174
	decreased anti-double stranded DNA antibody level	J:71174
	decreased B cell number	J:71174
	decreased B cell proliferation	J:71174
	decreased B-1 B cell number	J:71174
	decreased mature B cell number	J:71174
	decreased susceptibility to systemic lupus erythematosus	J:71174
	enlarged spleen	J:71174
	normal immune system phenotype	J:71174
Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal B cell negative selection	J:110531
	abnormal mature B cell morphology	J:110531
	increased IgM level	J:110531
Cd22^tm1Eac/Cd22⁺ Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal B cell negative selection	J:110531
	abnormal mature B cell morphology	J:110531
Fgr^tm1Hev/Fgr^tm1Hev Hck^tm1Hev/Hck^tm1Hev Lyn^tm1Sor/Lyn^tm1Sor B6.Cg-Hck^tm1Hev Fgr^tm1Hev Lyn^tm1Sor	abnormal inflammatory response	J:113463
	abnormal neutrophil physiology	J:113463
Igh-7^tm1Led/Igh-7^tm1Led Lyn^tm1Ard/Lyn^tm1Ard involves: 129P2/OlaHsd * 129S4/SvJae	abnormal circulating complement protein level	J:161523
	decreased B cell number	J:161523
	increased anti-double stranded DNA antibody level	J:161523
	increased anti-nuclear antigen antibody level	J:161523
	increased basophil cell number	J:161523
	increased IgA level	J:161523
	increased IgM level	J:161523
Igh^tm1Mnz/Igh^tm1Mnz Lyn^tm1Sor/Lyn^tm1Sor involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	abnormal B cell physiology	J:75653
	increased B cell proliferation	J:75653
Igh^tm2Mnz/Igh^tm2Mnz Lyn^tm1Sor/Lyn^tm1Sor involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	abnormal B cell physiology	J:75653
	increased B cell proliferation	J:75653
Il4^tm1Kopf/Il4^tm1Kopf Lyn^tm1Ard/Lyn^tm1Ard involves: 129P2/OlaHsd * 129S2/SvPas	abnormal circulating complement protein level	J:161523
	decreased B cell number	J:161523
	decreased IgE level	J:161523
	decreased IgG1 level	J:161523
	increased anti-double stranded DNA antibody level	J:161523
	increased anti-nuclear antigen antibody level	J:161523
	increased basophil cell number	J:161523
	increased IgA level	J:161523
	increased IgG2a level	J:161523
	increased IgG2b level	J:161523
	increased IgM level	J:161523
	increased mast cell number	J:161523
Il5ra^tm1Ktk/Il5ra^tm1Ktk Lyn^tm1Tya/Lyn^tm1Tya involves: 129P2/OlaHsd * C57BL/6	abnormal immune system organ morphology	J:91089
	abnormal spleen B cell corona morphology	J:91089
	abnormal spleen white pulp morphology	J:91089
	decreased B-1 B cell number	J:91089
	enlarged lymph nodes	J:91089
	enlarged spleen	J:91089
	glomerulonephritis	J:91089
	increased anti-double stranded DNA antibody level	J:91089
	increased IgA level	J:91089
	increased IgM level	J:91089
	increased immunoglobulin level	J:91089
Kit^W-sh/Kit^W-sh Lyn^tm1Ard/Lyn^tm1Ard involves: 101 * 129P2/OlaHsd * C3H/HeH	abnormal circulating complement protein level	J:161523
	albuminuria	J:161523
	decreased B cell number	J:161523
	glomerulonephritis	J:161523
	increased anti-double stranded DNA antibody level	J:161523
	increased anti-nuclear antigen antibody level	J:161523
	increased basophil cell number	J:161523
	increased IgA level	J:161523
	increased IgE level	J:161523
	increased IgG2b level	J:161523
	increased IgM level	J:161523
Lyn^mld4/Lyn^mld4 Mpl^tm1Wsa/Mpl^tm1Wsa B6.129S1-Mpl^tm1Wsa	decreased erythrocyte cell number	J:144799
	decreased leukocyte cell number	J:144799
	thrombocytopenia	J:144799
Lyn^tm1.1Calo/Lyn^tm1.1Calo Myd88^tm1Defr/Myd88^tm1Defr Tg(Itgax-cre)1-1Reiz/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	normal immune system phenotype	J:200745
	normal renal/urinary system phenotype	J:200745
Lyn^tm1Ard/Lyn⁺ Ptpn6^me-v/Ptpn6⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal mature B cell morphology	J:110531
Lyn^tm1Ard/Lyn⁺ Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal mature B cell morphology	J:110531
Lyn^tm1Ard/Lyn^tm1Ard Tg(IghelMD4)4Ccg/0 involves: 129P2/OlaHsd * C57BL/6	abnormal B cell activation	J:110531
	abnormal B cell negative selection	J:110531
	abnormal mature B cell morphology	J:110531
	absent B-1 B cells	J:110531
	increased IgM level	J:110531

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