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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mbp
myelin basic protein
MGI:96925
49 phenotypes from 5 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mbpjve/Mbpjve
involves: C57BL/6J 		abnormal action potential J:221049
abnormal brain white matter morphology J:221049
abnormal cerebellum white matter morphology J:221049
abnormal corpus callosum morphology J:221049
abnormal gait J:221049
absence seizures J:221049
decreased body weight J:221049
decreased locomotor activity J:221049
decreased startle reflex J:119820
environmentally induced seizures J:221049
increased or absent threshold for auditory brainstem response J:119820
premature death J:221049
tonic seizures J:221049
tremors J:221049
Mbpshi-J/Mbpshi-J
BALB/cJ-Mbpshi-J/GrsrJ 		abnormal auditory brainstem response waveform shape J:117543
abnormal myelin sheath morphology J:117543
abnormal myelination J:117543
ataxia J:117543
increased or absent threshold for auditory brainstem response J:117543
tremors J:117543
normal vision/eye phenotype J:117543
Mbpshi-mld+/Mbpshi-mld+
involves: C3H/HeJ * C57BL/6J * MDB/Dt 		convulsive seizures J:1873
demyelination J:1873
phenotypic reversion J:1873
reversion by mitotic recombination J:1873
tremors J:1873
Mbpshi/Mbp+
C3Fe.SWV-Mbpshi/J 		absent linear vestibular evoked potential J:116914
reduced linear vestibular evoked potential J:116914
Mbpshi/Mbpshi
C3Fe.SWV-Mbpshi/J 		abnormal myelin sheath morphology J:211344
decreased nerve conduction velocity J:211344
decreased susceptibility to Picornaviridae infection J:41447
normal immune system phenotype J:41447
limb grasping J:211344
reduced linear vestibular evoked potential J:116914
tremors J:211344
Mbpshi/Mbpshi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SWV 		abnormal myelin sheath morphology J:38856
abnormal myelination J:38856
ataxia J:38856
premature death J:38856
tremors J:38856
Mbpshi/Mbpshi
involves: BALB/c * C3HeB/Fe * SWV 		increased interferon-gamma secretion J:48412
increased interleukin-2 secretion J:48412
increased interleukin-4 secretion J:48412
increased susceptibility to experimental autoimmune encephalomyelitis J:48412
increased T cell proliferation J:48412
Mbpshi/Mbpshi
involves: C3H * ICR * SWV 		audiogenic seizures J:6578
environmentally induced seizures J:6578
hindlimb paralysis J:6578
premature death J:6578
tonic seizures J:6578
tremors J:6578
Mbpshi/Mbpshi
involves: SWV 		abnormal axonal transport J:57128
abnormal myelination J:57128
abnormal neuron morphology J:57128
impaired coordination J:127688
Mbpshi/Mbpshi
SWV-Mbpshi 		abnormal maternal nurturing J:6578
abnormal spatial learning J:27482
decreased brain cholesterol level J:9907
decreased cholesterol level J:9907
premature death J:6578
normal reproductive system phenotype J:6578
Mbpshi/Mbpshi
Tg(Thy1-YFP)HJrs/0
involves: C3HeB/Fe * C57BL/6 * CBA * SWV 		abnormal myelination J:158545
demyelination J:158545
impaired coordination J:158545
increased susceptibility to neuronal excitotoxicity J:158545
increased susceptibility to pharmacologically induced seizures J:158545
paresis J:158545
Mbptm1Atc/Mbptm1Atc
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal CNS synaptic transmission J:100022
abnormal myelination J:100022
abnormal oligodendrocyte morphology J:100022
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory