Mc3r Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mc3r
melanocortin 3 receptor
MGI:96929

37 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mc3r^em1(IMPC)Mbp/Mc3r^em1(IMPC)Mbp C57BL/6N-Mc3r^em1(IMPC)Mbp/MbpMmucd	abnormal kidney morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal testis morphology	J:211773
	decreased body length	J:211773
	decreased bone mineral content	J:211773
	decreased bone mineral density	J:211773
	decreased heart weight	J:211773
	decreased lean body mass	J:211773
	increased total body fat amount	J:211773
	small kidney	J:211773
	small testis	J:211773
Mc3r^tm1Butl/Mc3r^tm1Butl B6.Cg-Mc3r^tm1Butl	abnormal energy homeostasis	J:178147
	abnormal locomotor activation	J:178147
	decreased circulating triglyceride level	J:178147
	decreased energy expenditure	J:178147
	decreased lean body mass	J:178147
	decreased locomotor activity	J:178147
	decreased respiratory quotient	J:178147
	increased circulating insulin level	J:178147
	increased circulating leptin level	J:178147
	increased inflammatory response	J:178147
	increased susceptibility to diet-induced obesity	J:178147
	increased total body fat amount	J:178147
Mc3r^tm1Butl/Mc3r^tm1Butl Tg(Nes-cre)1Kln/0 B6.Cg-Mc3r^tm1Butl Tg(Nes-Cre)1Kln	abnormal body fat mass	J:178147
	decreased lean body mass	J:178147
	increased susceptibility to diet-induced obesity	J:178147
Mc3r^tm1Butl/Mc3r^tm1Butl Tg(Nr5a1-cre)2Lowl/0 involves: C57BL/6J * FVB/NJ	abnormal adipose tissue amount	J:178147
	abnormal circulating leptin level	J:178147
	abnormal energy homeostasis	J:178147
	abnormal locomotor activation	J:178147
	decreased circulating triglyceride level	J:178147
	decreased lean body mass	J:178147
	normal homeostasis/metabolism phenotype	J:178147
Mc3r^tm1Cone/Mc3r⁺ involves: 129S4/SvJae * C57BL/6J	obese	J:78132
Mc3r^tm1Cone/Mc3r^tm1Cone B6.129S4-Mc3r^tm1Cone	decreased compensatory feeding amount	J:109494
Mc3r^tm1Cone/Mc3r^tm1Cone involves: 129S4/SvJae * C57BL/6J	abnormal food intake	J:78132
	abnormal respiratory quotient	J:78132
	increased body weight	J:78132
	increased total body fat amount	J:78132
	obese	J:78132
Mc3r^tm1Lex/Mc3r^tm1Lex involves: 129S5/SvEvBrd * C57BL/6J	increased percent body fat/body weight	J:185494
Mc3r^tm1Lvp/Mc3r^tm1Lvp involves: 129S7/SvEvBrd * C57BL/6J	abnormal brown fat cell morphology	J:64365
	abnormal eating behavior	J:64365
	abnormal motor capabilities/coordination/movement	J:64365
	decreased body length	J:64365
	decreased brown fat cell number	J:64365
	decreased lean body mass	J:64365
	decreased locomotor activity	J:64365
	increased body weight	J:64365
	increased circulating insulin level	J:64365
	increased circulating leptin level	J:64365
	increased susceptibility to diet-induced obesity	J:64365
	increased total body fat amount	J:64365
	increased white fat cell size	J:64365
	short femur	J:64365

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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