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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mdm2
transformed mouse 3T3 cell double minute 2
MGI:96952
68 phenotypes from 15 alleles in 11 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mdm2Gt(Ex65)Byg/Mdm2Gt(Ex65)Byg
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality, complete penetrance J:70273
Mdm2tm1.1Mep/Mdm2tm1.1Mep
involves: 129S7/SvEvBrd * C57BL/6 		prenatal lethality, complete penetrance J:81065
Mdm2tm1.1Ypz/Mdm2tm1.1Ypz
B6.129-Mdm2tm1.1Ypz 		increased cell proliferation J:164200
Mdm2tm1Bay/Mdm2+
B6.129S7-Mdm2tm1Bay 		increased mortality induced by gamma-irradiation J:81065
Mdm2tm1Bay/Mdm2tm1.1Mep
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		prenatal lethality, complete penetrance J:81065
Mdm2tm1Bay/Mdm2tm1.2Mep
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		no abnormal phenotype detected J:81065
Mdm2tm1Bay/Mdm2tm1Bay
involves: 129S7/SvEvBrd 		abnormal embryonic tissue morphology J:29811
embryonic lethality between implantation and somite formation, complete penetrance J:29811
Mdm2tm1Bay/Mdm2tm1Mep
involves: 129S7/SvEvBrd * C57BL/6 		abnormal B cell differentiation J:81065
abnormal cell cycle checkpoint function J:81065
anemia J:81065
decreased body weight J:81065
decreased bone marrow cell number J:81065
decreased cell proliferation J:81065
decreased double-negative T cell number J:81065
decreased double-positive T cell number J:81065
decreased erythrocyte cell number J:81065
decreased granulocyte number J:81065
decreased immature B cell number J:81065
decreased kidney weight J:81065
decreased leukocyte cell number J:81065
decreased liver weight J:81065
decreased lymphocyte cell number J:81065
decreased neutrophil cell number J:81065
decreased spleen weight J:81065
decreased T cell number J:81065
decreased thymocyte number J:81065
decreased thymus weight J:81065
increased cellular sensitivity to ionizing radiation J:81065
prenatal lethality, incomplete penetrance J:81065
spleen hypoplasia J:81065
thymus hypoplasia J:81065
Mdm2tm1Glo/Mdm2+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal cell physiology J:123661
increased mortality induced by ionizing radiation J:123661
Mdm2tm1Glo/Mdm2+
involves: 129S7/SvEvBrd 		increased foot pad pigmentation J:174216
Mdm2tm1Glo/Mdm2tm1Glo
involves: 129S7/SvEvBrd 		abnormal hematopoietic system physiology J:158953
Mdm2tm1Glo/Mdm2tm1Glo
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal embryonic tissue morphology J:29810
embryonic lethality between implantation and somite formation, complete penetrance J:29810
empty decidua capsularis J:29810
Mdm2tm1Glo/Mdm2tm2.1Glo
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:75118
Mdm2tm1Glo/Mdm2tm2.1Glo
Tg(Myh6-cre)2182Mds/0
involves: 129S7/SvEvBrd * FVB/N 		abnormal blood circulation J:104114
abnormal cardiovascular system physiology J:104114
abnormal heart morphology J:104114
abnormal heart ventricle morphology J:104114
decreased embryo size J:104114
embryonic lethality during organogenesis, complete penetrance J:104114
hemorrhage J:104114
increased cardiomyocyte apoptosis J:104114
small heart J:104114
thin myocardium J:104114
Mdm2tm1Glo/Mdm2tm2Glo
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:75118
Mdm2tm1Mep/Mdm2+
involves: 129S7/SvEvBrd * C57BL/6 		increased mortality induced by gamma-irradiation J:81065
Mdm2tm1Mep/Mdm2tm1.1Mep
involves: 129S7/SvEvBrd * C57BL/6 * FVB 		decreased body weight J:81065
decreased kidney weight J:81065
decreased liver weight J:81065
decreased spleen weight J:81065
decreased thymus weight J:81065
Mdm2tm1Mep/Mdm2tm1Mep
involves: 129S7/SvEvBrd * C57BL/6 		normal growth/size/body region phenotype J:81065
Mdm2tm1Snj/Mdm2tm1Bay
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:75119
Mdm2tm1Snj/Mdm2tm1Snj
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:75119
Mdm2tm1Ypz/Mdm2tm1Ypz
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		abnormal gastrulation J:126004
decreased embryo size J:126004
embryonic growth retardation J:126004
embryonic lethality between implantation and somite formation, complete penetrance J:126004
Mdm2tm2.1Glo/Mdm2tm2.1Glo
involves: 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:75118
Mdm2tm2.1Snj/Mdm2tm2.1Snj
involves: 129S4/SvJae * C57BL/6 		abnormal cell cycle J:189297
abnormal kidney morphology J:189297
abnormal liver morphology J:189297
decreased apoptosis J:189297
decreased mortality induced by ionizing radiation J:189297
decreased thymocyte apoptosis J:189297
enlarged spleen J:189297
increased B cell derived lymphoma incidence J:189297
increased T cell derived lymphoma incidence J:189297
increased tumor incidence J:189297
Mdm2tm2.3Glo/Mdm2tm2.3Glo
involves: 129S7/SvEvBrd * C57BL/6J 		prenatal lethality, complete penetrance J:75118
Mdm2tm3.1Snj/Mdm2tm3.1Snj
involves: 129S4/SvJae * C57BL/6 		normal cellular phenotype J:189297
normal immune system phenotype J:189297
increased salivary gland tumor incidence J:189297
Tg(Mdm2)1Snj/0
involves: 129S7/SvEvBrd * C57BL/6 		increased adenocarcinoma incidence J:51661
increased hemangiosarcoma incidence J:51661
increased lymphoma incidence J:51661
increased pituitary adenoma incidence J:51661
increased rhabdomyosarcoma incidence J:51661
increased sarcoma incidence J:51661
increased tumor incidence J:51661
Tg(Mdm2)1Snj/Tg(Mdm2)1Snj
involves: 129S7/SvEvBrd * C57BL/6 		increased tumor incidence J:51661
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory