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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mdm2
transformed mouse 3T3 cell double minute 2
MGI:96952
77 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mdm2tm1.1Ypz/Mdm2+
Tg(IghMyc)22Bri/0
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri 		premature death J:164200
Mdm2tm1.1Ypz/Mdm2tm1.1Ypz
Tg(IghMyc)22Bri/0
B6.Cg-Mdm2tm1.1Ypz Tg(IghMyc)22Bri 		enlarged liver J:164200
enlarged lymph nodes J:164200
enlarged Peyer's patches J:164200
enlarged thymus J:164200
increased lymphoma incidence J:164200
premature death J:164200
spleen hyperplasia J:164200
Mdm2tm1Bay/Mdm2+
Rpl27aSfa/Rpl27a+
involves: 129S7/SvEvBrd * C57BL/6J 		prenatal lethality, complete penetrance J:174216
Mdm2tm1Bay/Mdm2tm1Bay
Trp53tm1Brd/Trp53tm1Brd
involves: 129S7/SvEvBrd 		no abnormal phenotype detected J:29811
Mdm2tm1Bay/Mdm2tm1Bay
Trp53tm1Snj/Trp53tm1Snj
involves: C57BL/6 		prenatal lethality, complete penetrance J:87687
Mdm2tm1Bay/Mdm2tm1Bay
Trp53tm2.1Kasa/Trp53tm2.1Kasa
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		prenatal lethality, complete penetrance J:186335
Mdm2tm1Bay/Mdm2tm1Mep
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 		abnormal bone marrow cell morphology/development J:81065
abnormal small intestine morphology J:81065
decreased mortality induced by ionizing radiation J:81065
normal hematopoietic system phenotype J:81065
Mdm2tm1Glo/Mdm2+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		normal mortality/aging J:123661
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6 		abnormal cell cycle J:108183
Mdm2tm1Glo/Mdm2+
Mdm4Gt(VICTR20)7Lex/Mdm4+
Trp53tm3Wahl/Trp53tm3Wahl
involves: 129 		abnormal cell cycle J:108183
Mdm2tm1Glo/Mdm2+
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S7/SvEvBrd * C57BL/6 		abnormal cell cycle J:108183
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		abnormal cell physiology J:123661
abnormal cerebellar granule layer morphology J:123661
abnormal cerebellum external granule cell layer morphology J:123661
abnormal definitive hematopoiesis J:123661
abnormal Purkinje cell morphology J:123661
anemia J:123661
cerebellum hypoplasia J:123661
cleft palate J:123661
decreased body weight J:123661
decreased bone marrow cell number J:123661
decreased embryo size J:123661
decreased erythrocyte cell number J:123661
decreased fetal size J:123661
decreased hemoglobin content J:123661
decreased leukocyte cell number J:123661
decreased renal glomerulus number J:123661
exencephaly J:123661
increased embryonic tissue cell apoptosis J:123661
kinked tail J:123661
pallor J:123661
pancytopenia J:123661
postnatal lethality, complete penetrance J:123661
prenatal lethality, incomplete penetrance J:123661
spleen atrophy J:123661
spleen hypoplasia J:123661
thrombocytopenia J:123661
thymus atrophy J:123661
thymus hypoplasia J:123661
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
involves: 129S7/SvEvBrd 		abnormal Purkinje cell morphology J:174216
anemia J:174216
decreased bone marrow cell number J:174216
decreased cerebellar granule cell number J:174216
increased foot pad pigmentation J:174216
normal mortality/aging J:71532
small cerebellum J:174216
Mdm2tm1Glo/Mdm2+
Mdm4tm1Glo/Mdm4+
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 		normal mortality/aging J:123661
Mdm2tm1Glo/Mdm2+
Mdm4tm2.1Glo/Mdm4+
involves: 129S7/SvEvBrd 		increased foot pad pigmentation J:174216
Mdm2tm1Glo/Mdm2+
Trp53tm2Wahl/Trp53tm2Wahl
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 		abnormal bone marrow morphology J:174375
decreased erythrocyte cell number J:174375
decreased leukocyte cell number J:174375
increased mortality induced by ionizing radiation J:174375
small thymus J:174375
spleen atrophy J:174375
thrombocytopenia J:174375
Mdm2tm1Glo/Mdm2+
Trp53tm3Wahl/Trp53tm3Wahl
involves: 129S4/SvJae * 129S7/SvEvBrd 		abnormal cell cycle J:108183
Mdm2tm1Glo/Mdm2+
Trp53tm1.1Tldo/Trp53+
involves: 129S2/SvPas * 129S7/SvEvBrd * BALB/c * C57BL/6 		decreased bone marrow cell number J:199308
decreased telomere length J:199308
premature death J:199308
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Adv/Trp53tm1Adv
involves: 129S7/SvEvBrd 		embryonic lethality between somite formation and embryo turning, complete penetrance J:93838
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Glo/Trp53tm1Glo
involves: 129S7/SvEvBrd * C57BL/6 		embryonic lethality, complete penetrance J:171821
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Glo/Trp53tm4Glo
involves: 129S7/SvEvBrd * C57BL/6 		decreased body size J:171821
decreased locomotor activity J:171821
postnatal lethality, complete penetrance J:171821
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S7/SvEvBrd 		abnormal embryonic tissue morphology J:93838
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S7/SvEvBrd 		normal mortality/aging J:93838
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6J 		no abnormal phenotype detected J:29810
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm1Wahl/Trp53tm1Wahl
involves: 129S7/SvEvBrd * C57BL/6 		prenatal lethality, complete penetrance J:108183
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm2Glo/Trp53tm2Glo
involves: 129S7/SvEvBrd 		abnormal Purkinje cell morphology J:174216
anemia J:174216
decreased bone marrow cell number J:174216
decreased cerebellar granule cell number J:174216
small cerebellum J:174216
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53+
involves: 129S7/SvEvBrd * C57BL/6 		prenatal lethality, complete penetrance J:95318
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3.1Glo/Trp53tm4Glo
involves: 129S7/SvEvBrd * C57BL/6 		normal mortality/aging J:171821
Mdm2tm1Glo/Mdm2tm1Glo
Trp53tm3Wahl/Trp53tm3Wahl
involves: 129S4/SvJae * 129S7/SvEvBrd 		prenatal lethality, complete penetrance J:108183
Mdm2tm1Glo/Mdm2tm2.1Glo
Tg(Myh6-cre)2182Mds/0
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S7/SvEvBrd * FVB/N 		normal cardiovascular system phenotype J:104114
Mdm2tm1Ypz/Mdm2tm1Ypz
Trp53tm1Tyj/Trp53+
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB/N 		postnatal lethality J:126004
Mdm2tm1Ypz/Mdm2tm1Ypz
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB/N 		normal mortality/aging J:126004
Mdm2tm3.1Glo/Mdm2tm3.1Glo
B6.129S6-Mdm2tm3.1Glo 		decreased cellular sensitivity to ionizing radiation J:164201
increased fibroblast proliferation J:164201
increased lymphoma incidence J:164201
increased mammary adenocarcinoma incidence J:164201
increased tumor incidence J:164201
premature death J:164201
Mdm2tm3.1Glo/Mdm2tm3.1Glo
Trp53tm3.1Glo/Trp53+
B6.129S-Mdm2tm3.1Glo Trp53tm3.1Glo 		decreased cellular sensitivity to ionizing radiation J:164201
increased adenocarcinoma incidence J:164201
increased carcinoma incidence J:164201
increased fibrosarcoma incidence J:164201
increased hemangiosarcoma incidence J:164201
increased histiocytic sarcoma incidence J:164201
increased leiomyosarcoma incidence J:164201
increased lipoma incidence J:164201
increased liver adenocarcinoma incidence J:164201
increased liver adenoma incidence J:164201
increased lung adenoma incidence J:164201
increased lymphoma incidence J:164201
increased mammary adenocarcinoma incidence J:164201
increased osteosarcoma incidence J:164201
increased papilloma incidence J:164201
increased sarcoma incidence J:164201
increased squamous cell carcinoma incidence J:164201
increased tumor incidence J:164201
premature death J:164201
Mdm2tm4.1Glo/Mdm2tm4.1Glo
B6.129S6-Mdm2tm4.1Glo 		normal cellular phenotype J:164201
increased sarcoma incidence J:164201
Mdm2tm4.1Glo/Mdm2tm4.1Glo
Trp53tm3.1Glo/Trp53+
B6.129S-Mdm2tm4.1Glo Trp53tm3.1Glo 		increased adenocarcinoma incidence J:164201
increased carcinoma incidence J:164201
increased fibrosarcoma incidence J:164201
increased histiocytic sarcoma incidence J:164201
increased liver adenocarcinoma incidence J:164201
increased lymphoma incidence J:164201
increased osteosarcoma incidence J:164201
increased sarcoma incidence J:164201
increased squamous cell carcinoma incidence J:164201
Tg(Mdm2)1Snj/0
Trp53tm1Brd/Trp53tm1Brd
involves: 129S7/SvEvBrd * C57BL/6 		increased hemangiosarcoma incidence J:51661
increased lymphoma incidence J:51661
increased medulloblastoma incidence J:51661
increased osteosarcoma incidence J:51661
increased squamous cell carcinoma incidence J:51661
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory