Mertk Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mertk
MER proto-oncogene tyrosine kinase
MGI:96965

40 phenotypes from 4 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mertk^nmf12/Mertk^nmf12 C57BL/6J-Mertk^nmf12/J	abnormal retina morphology	J:82238
Mertk^nmf12/Mertk^nmf12 C57BL/6J-Mertk^nmf12/J	decreased total retina thickness	J:82238
Mertk^nmf12/Mertk^nmf12 involves: C57BL/6J	abnormal eye electrophysiology	J:175587
	abnormal retina photoreceptor layer morphology	J:175587
	abnormal retina pigmentation	J:175587
	abnormal tumor necrosis factor level	J:175587
	decreased retina photoreceptor cell number	J:175587
	increased retina apoptosis	J:175587
	retina photoreceptor degeneration	J:175587
	thin retina outer nuclear layer	J:175587
Mertk^nmf12/Mertk^tm1Gkm involves: 129P2/OlaHsd * C57BL/6J	abnormal retina morphology	J:175587
	decreased retina photoreceptor cell number	J:175587
	thin retina outer nuclear layer	J:175587
Mertk^tm1Gkm/Mertk^tm1Gkm B6.129P2-Mertk^tm1Gkm	decreased autoantibody level	J:136377
Mertk^tm1Gkm/Mertk^tm1Gkm B6.129P2-Mertk^tm1Gkm	decreased susceptibility to graft versus host disease	J:136377
Mertk^tm1Gkm/Mertk^tm1Gkm involves: 129P2/OlaHsd	abnormal cone electrophysiology	J:81618
	abnormal photoreceptor outer segment morphology	J:81618
	abnormal retina morphology	J:81618
	abnormal retina outer nuclear layer morphology	J:81618
	abnormal retina pigment epithelium morphology	J:81618
	abnormal retina vasculature morphology	J:81618
	abnormal rod electrophysiology	J:81618
	disorganized photoreceptor outer segment	J:81618
	photoreceptor outer segment degeneration	J:81618
	retina degeneration	J:81618
	retina pigment epithelium atrophy	J:81618
	retina rod cell degeneration	J:81618
	thin retina outer nuclear layer	J:81618
Mertk^tm1Gkm/Mertk^tm1Gkm involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal small intestine morphology	J:53423
	increased circulating tumor necrosis factor level	J:53423
	increased susceptibility to endotoxin shock	J:53423
	increased susceptibility to induced morbidity/mortality	J:53423
	increased tumor necrosis factor secretion	J:53423
Mertk^tm1Gkm/Mertk^tm1Gkm NOD.129P2-Mertk^tm1Gkm	abnormal mononuclear cell morphology	J:147153
	decreased susceptibility to autoimmune diabetes	J:147153
	decreased T cell number	J:147153
	increased T cell apoptosis	J:147153
	insulitis	J:147153
Mertk^tm1Grl/Mertk^tm1Grl involves: 129P2/OlaHsd	abnormal photoreceptor outer segment morphology	J:116526
	abnormal retina pigment epithelium morphology	J:116526
	blindness	J:116526
	normal cardiovascular system phenotype	J:198769
	decreased Sertoli cell phagocytosis	J:133455
	disorganized photoreceptor outer segment	J:116526
	enlarged spleen	J:54681
	retina photoreceptor degeneration	J:116526
	vagina atresia	J:142166
Mertk^tm1Lex/Mertk^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	decreased platelet aggregation	J:102333
Mertk^tm1Lex/Mertk^tm1Lex involves: 129S5/SvEvBrd * C57BL/6	decreased susceptibility to induced thrombosis	J:102333

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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