Met Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Met
met proto-oncogene
MGI:96969

50 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Cd44^tm1Mak/Cd44^tm1Mak Met^tm1Cbm/Met⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal miniature excitatory postsynaptic currents	J:128984
	abnormal miniature inhibitory postsynaptic currents	J:128984
	abnormal phrenic nerve morphology	J:128984
	decreased miniature inhibitory postsynaptic current frequency	J:128984
	lethality, incomplete penetrance	J:128984
	neonatal lethality, incomplete penetrance	J:128984
	primary atelectasis	J:128984
	respiratory distress	J:128984
Gab1^tm1Wbm/Gab1^tm1Wbm Met^tm1Cbm/Met^tm1Cbm involves: 129P2/OlaHsd * C57BL/6	hypaxial muscle hypoplasia	J:68751
Gab1^tm3Wbm/Gab1^tm3Wbm Met^tm1Cbm/Met⁺ involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1	cleft secondary palate	J:125303
Met^tm1Cpo/Met⁺ Pax3^{tm2.1(PAX3/FOXO1A)Buck}/Pax3⁺ involves: 129 * BALB/c * C57BL/6	normal embryo phenotype	J:86911
Met^tm1Cpo/Met^tm1Cpo involves: 129S1/Sv * 129X1/SvJ	abnormal axon extension	J:174591
	abnormal neuron physiology	J:174591
	normal nervous system phenotype	J:174591
Met^tm1Cpo/Met^tm1Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6	absent skeletal muscle	J:98439
	normal muscle phenotype	J:98439
Met^tm1Cpo/Met^tm1Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal muscle development	J:36244
	abnormal tongue muscle morphology	J:36244
	absent diaphragm	J:36244
	decreased embryo size	J:36244
	lethality throughout fetal growth and development, complete penetrance	J:36244
	pale placenta	J:36244
	small placenta	J:36244
Met^tm1Cpo/Met^tm1Cpo Pax3^{tm2.1(PAX3/FOXO1A)Buck}/Pax3⁺ involves: 129 * BALB/c * C57BL/6	normal embryo phenotype	J:86911
Met^tm1Cpo/Met^tm1Sst Tg(Nes-cre)1Kln/? involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL	normal vision/eye phenotype	J:173661
Met^tm1Cpo/Met^tm1Sst Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal motor neuron innervation pattern	J:174591
	abnormal neuromuscular synapse morphology	J:174591
	decreased motor neuron number	J:174591
	impaired coordination	J:174591
Met^tm1Cpo/Met^tm2Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	decreased skeletal muscle mass	J:36244
	neonatal lethality, complete penetrance	J:36244
	respiratory failure	J:36244
Met^tm1Gvw/Met⁺ involves: 129 * C57BL/6J	chromosome breakage	J:94722
	glomerulonephritis	J:94722
	hydronephrosis	J:94722
	increased carcinoma incidence	J:94722
	increased histiocytic sarcoma incidence	J:94722
	increased lymphoma incidence	J:94722
	increased squamous cell carcinoma incidence	J:94722
	increased tumor incidence	J:94722
Met^tm1Gvw/Met^tm1Gvw involves: 129 * C57BL/6J	embryonic lethality between implantation and somite formation, complete penetrance	J:94722
Met^tm1Ics/Met^tm1Sst Tg(Nes-cre)1Kln/0 involves: 129P2/OlaHsd * C57BL/6 * SJL	decreased motor neuron number	J:174591
Met^tm1Sst/Met^tm1Sst Trp53^tm1Brn/Trp53^tm1Brn involves: 129P2/OlaHsd	normal cellular phenotype	J:175978
Met^tm1Sst/Met^tm1Sst Trp53^tm1Brn/Trp53^tm2Tyj involves: 129P2/OlaHsd * 129S4/SvJae	normal cellular phenotype	J:175978
Met^tm1Sst/Met^tm1Sst Trp53^tm1Brn/Trp53^tm3Tyj involves: 129P2/OlaHsd * 129S4/SvJae	normal cellular phenotype	J:175978
Met^tm2Cpo/Met^tm2Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal forelimb morphology	J:36244
	decreased skeletal muscle mass	J:36244
	neonatal lethality, complete penetrance	J:36244
	paraparesis	J:36244
	postnatal growth retardation	J:36244
Met^tm2Cpo/Met^tm4.1Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal neuron differentiation	J:81793
	impaired coordination	J:81793
	reduced cerebellar foliation	J:81793
	small cerebellum	J:81793
Met^tm2Gvw/Met⁺ involves: 129 * C57BL/6J	chromosome breakage	J:94722
	glomerulonephritis	J:94722
	hydronephrosis	J:94722
	increased hemangiosarcoma incidence	J:94722
	increased histiocytic sarcoma incidence	J:94722
	increased lymphoma incidence	J:94722
	increased tumor incidence	J:94722
	premature death	J:94722
Met^tm2Gvw/Met^tm2Gvw involves: 129 * C57BL/6J	embryonic lethality between implantation and somite formation, complete penetrance	J:94722
Met^tm3Cpo/Met^tm3Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	no abnormal phenotype detected	J:36244
Met^tm3Gvw/Met^tm3Gvw involves: 129 * C57BL/6J	chromosome breakage	J:94722
	increased hemangiosarcoma incidence	J:94722
	increased tumor incidence	J:94722
	premature death	J:94722
Met^tm4Cpo/Met^tm2Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal forelimb morphology	J:81793
	neonatal lethality, complete penetrance	J:81793

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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