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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kmt2a
lysine (K)-specific methyltransferase 2A
MGI:96995
76 phenotypes from 13 alleles in 16 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Kmt2atm1.1Erns/Kmt2atm1.1Erns
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL 		normal immune system phenotype J:147265
Kmt2atm1.1Brad/Kmt2atm1.1Brad
involves: 129S4/SvJae * C57BL/6 		abnormal hematopoietic stem cell morphology J:149811
abnormal liver development J:149811
decreased common myeloid progenitor cell number J:149811
decreased hematopoietic stem cell number J:149811
lethality throughout fetal growth and development, complete penetrance J:149811
Kmt2atm1.1Erns/Kmt2atm1.1Erns
involves: 129S2/SvPas * C57BL/6 * SJL 		abnormal definitive hematopoiesis J:147265
decreased common myeloid progenitor cell number J:147265
decreased erythroid progenitor cell number J:147265
Kmt2atm1.1Erns/Kmt2atm1.1Erns
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL 		normal immune system phenotype J:147265
Kmt2atm1.1Erns/Kmt2atm1.1Erns
Tg(GFAP-cre)25Mes/0
involves: 129S2/SvPas * FVB/N 		abnormal astrocyte morphology J:147104
abnormal brain development J:147104
abnormal dentate gyrus morphology J:147104
abnormal neuron differentiation J:147104
abnormal neuronal precursor cell migration J:147104
abnormal postnatal subventricular zone morphology J:147104
ataxia J:147104
decreased neuronal precursor cell number J:147104
postnatal growth retardation J:147104
premature death J:147104
small olfactory bulb J:147104
thin cerebellar granule layer J:147104
Kmt2atm1.1Erns/Kmt2atm1.1Erns
Tg(Lck-cre)1Cwi/0
involves: 129S2/SvPas * C57BL/6 * SJL 		normal immune system phenotype J:147265
Kmt2atm1.1Erns/Kmt2atm1.1Erns
Tg(Mx1-cre)1Cgn/0
involves: 129S2/SvPas * C57BL/6 * CBA * SJL 		abnormal common lymphocyte progenitor cell morphology J:147265
abnormal definitive hematopoiesis J:147265
abnormal hematopoietic stem cell morphology J:147265
decreased bone marrow cell number J:147265
decreased common myeloid progenitor cell number J:147265
decreased erythroid progenitor cell number J:147265
decreased hematopoietic stem cell number J:147265
premature death J:147265
Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
B6.129X1-Kmt2atm1.1Jjdh 		abnormal arcus anterior morphology J:201612
decreased body size J:201612
glossopharyngeal nerve hypoplasia J:201612
sternebra fusion J:201612
Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
involves: 129X1/SvJ 		decreased fibroblast proliferation J:112159
Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
involves: 129P2/OlaHsd * C57BL/6 		abnormal blood cell morphology/development J:183048
abnormal hematopoietic stem cell physiology J:183048
decreased common myeloid progenitor cell number J:183048
decreased hematopoietic stem cell number J:183048
early cellular replicative senescence J:183048
embryonic lethality during organogenesis, complete penetrance J:183048
hemorrhage J:183048
hunched posture J:183048
liver hypoplasia J:183048
skin edema J:183048
Kmt2atm1.2Erns/Kmt2atm1.2Erns
involves: 129S2/SvPas * C57BL/6 * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:147265
Kmt2atm1Brad/Kmt2atm1Brad
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal bone marrow cell physiology J:149811
decreased common myeloid progenitor cell number J:149811
decreased pre-B cell number J:149811
Kmt2atm1Clgr/Kmt2a+
B6.129-Kmt2atm1Clgr 		abnormal common myeloid progenitor cell morphology J:115001
abnormal myelopoiesis J:115001
abnormal paraxial mesoderm morphology J:115001
abnormal proerythroblast morphology J:115001
abnormal rostral-caudal axis patterning J:115001
decreased rib number J:115001
increased erythroid progenitor cell number J:115001
normal neoplasm J:115001
sacral vertebral transformation J:115001
thoracic vertebral transformation J:115001
vertebral transformation J:115001
Kmt2atm1Clgr/Kmt2atm1Clgr
B6.129-Kmt2atm1Clgr 		perinatal lethality, complete penetrance J:115001
Kmt2atm1Djab/Kmt2atm1Djab
involves: 129P2/OlaHsd * BALB/c 		abnormal arcus anterior morphology J:109102
abnormal cervical axis morphology J:109102
cervical vertebral transformation J:109102
increased sternebra number J:109102
rib fusion J:109102
Kmt2atm1Saam/Kmt2a+
involves: 129S1/Sv * C57BL/6 		perinatal lethality, incomplete penetrance J:140628
Kmt2atm1Saam/Kmt2a+
Tg(Mx1-cre)1Cgn/0
involves: 129S1/Sv * C57BL/6 * CBA 		increased leukemia incidence J:140628
Kmt2atm1Sjk/Kmt2a+
involves: 129S2/SvPas * C3H * C57BL/6 		abnormal sternum morphology J:29958
anemia J:29958
cervical vertebral transformation J:29958
decreased B cell number J:29958
decreased birth body size J:29958
decreased erythrocyte cell number J:29958
decreased hemoglobin content J:29958
decreased rib number J:29958
lumbar vertebral transformation J:29958
postnatal growth retardation J:29958
reduced female fertility J:29958
thoracic vertebral transformation J:29958
thrombocytopenia J:29958
vertebral transformation J:29958
Kmt2atm1Sjk/Kmt2atm1.2Erns
involves: 129S2/SvPas * C57BL/6 * FVB/N 		embryonic lethality during organogenesis, complete penetrance J:147265
Kmt2atm1Sjk/Kmt2atm1Sjk
involves: 129S2/SvPas * C3H * C57BL/6 		embryonic lethality, complete penetrance J:29958, J:147265
Kmt2atm1Sjk/Kmt2atm1Sjk
involves: 129S2/SvPas * CD-1 		abnormal myoblast differentiation J:201612
glossopharyngeal nerve hypoplasia J:201612
Kmt2atm1Vss/Kmt2a+
involves: 129P2/OlaHsd * C57BL/6 		abnormal cervical atlas morphology J:71498
abnormal cervical axis morphology J:71498
abnormal cervical vertebrae morphology J:71498
abnormal cranial ganglia morphology J:71498
abnormal dorsal root ganglion morphology J:71498
abnormal rib development J:71498
abnormal vertebral arch morphology J:71498
cervical vertebral fusion J:71498
lumbar vertebral transformation J:71498
thoracic vertebral transformation J:71498
vertebral transformation J:71498
Kmt2atm1Vss/Kmt2atm1Vss
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality before implantation, complete penetrance J:71498
Kmt2atm2.1Mlc/Kmt2atm2.1Mlc
involves: 129P2/OlaHsd * C57BL/6 		abnormal hematopoietic system morphology/development J:207555
decreased hematopoietic stem cell number J:207555
embryonic lethality, complete penetrance J:207555
hemorrhage J:207555
skin edema J:207555
Kmt2atm3Mlc/Kmt2atm3Mlc
involves: 129P2/OlaHsd * C57BL/6 		no abnormal phenotype detected J:207555
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory