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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Kmt2a
lysine (K)-specific methyltransferase 2A
MGI:96995
53 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Flt3tm1Dgg/Flt3+
Kmt2atm1Clgr/Kmt2a+
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J 		anemia J:189096
enlarged spleen J:189096
increased erythroblast number J:189096
increased leukemia incidence J:189096
increased leukocyte cell number J:189096
premature death J:189096
thrombocytopenia J:189096
Flt3tm1Dgg/Flt3tm1Dgg
Kmt2atm1Clgr/Kmt2a+
involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6J 		enlarged spleen J:189096
increased leukemia incidence J:189096
increased leukocyte cell number J:189096
premature death J:189096
Kmt2atm1(AFF1)Ksy/Kmt2a+
involves: 129S1/Sv * C57BL/6 * FVB 		abnormal behavior J:110241
abnormal blood cell morphology/development J:110241
abnormal facial morphology J:110241
abnormal lymphocyte morphology J:110241
abnormal tail position or orientation J:110241
big ears J:110241
decreased birth body size J:110241
decreased body weight J:110241
enlarged spleen J:110241
hunched posture J:110241
increased B cell derived lymphoma incidence J:110241
increased leukemia incidence J:110241
increased leukocyte cell number J:110241
increased malignant tumor incidence J:110241
increased monocyte cell number J:110241
increased neutrophil cell number J:110241
increased pro-B cell number J:110241
increased spleen neoplasm incidence J:110241
lymphoid hyperplasia J:110241
myeloid hyperplasia J:110241
premature death J:110241
rough coat J:110241
short snout J:110241
Kmt2atm1(MLL1/ERT)Divo/?
involves: 129S4/SvJae * C57BL/6 		enlarged liver J:189329
enlarged spleen J:189329
increased acute promyelocytic leukemia incidence J:189329
myeloid hyperplasia J:189329
premature death J:189329
Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+
involves: 129S/SvEv * C57BL/6 		no abnormal phenotype detected J:205605
Kmt2atm1.1(Sh3gl1)Lcc/Kmt2a+
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 		enlarged liver J:205605
enlarged lymph nodes J:205605
enlarged spleen J:205605
increased leukemia incidence J:205605
myeloid hyperplasia J:205605
premature death J:205605
Kmt2atm1.1Erns/Kmt2atm1.1Erns
Tg(CAG-Bgeo/GFP)21Lbe/0
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal neuron differentiation J:147104
decreased neuronal precursor cell number J:147104
Kmt2atm1.1Jjdh/Kmt2atm1.1Jjdh
Kmt2btm1Jjdh/Kmt2btm1Jjdh
involves: 129X1/SvJ 		decreased fibroblast proliferation J:112159
normal reproductive system phenotype J:205038
Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Trp53tm1Brd/Trp53tm1Brd
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		normal cellular phenotype J:183048
Kmt2atm1Thr/Kmt2a+
Mllt3tm2Thr/Mllt3+
Tg(Lck-cre)1Thr/?
involves: 129S/SvEv 		abnormal spleen red pulp morphology J:100794
abnormal spleen white pulp morphology J:100794
enlarged spleen J:100794
increased hemolymphoid system tumor incidence J:100794
increased leukemia incidence J:100794
increased T cell derived lymphoma incidence J:100794
Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
Tg(Lck-cre)1Thr/?
involves: 129S/SvEv 		normal neoplasm J:100794
Kmt2atm1Tok/Kmt2a+
Sf3b1tm1Hko/Sf3b1+
involves: C57BL/6 		normal skeleton phenotype J:96358
Kmt2atm2(MLLT3)Thr/Kmt2a+
involves: 129P2/OlaHsd 		abnormal definitive hematopoiesis J:56340
enlarged liver J:56340
enlarged spleen J:56340
increased leukemia incidence J:56340
pale kidney J:56340
Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
involves: 129P2/OlaHsd 		prenatal lethality J:56340
Kmt2atm2(MLLT3)Thr/Kmt2atm2(MLLT3)Thr
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal blood cell morphology/development J:110241
abnormal definitive hematopoiesis J:110241
big ears J:110241
decreased body size J:110241
decreased body weight J:110241
increased B cell derived lymphoma incidence J:110241
increased hemolymphoid system tumor incidence J:110241
increased leukemia incidence J:110241
increased leukocyte cell number J:110241
increased neutrophil cell number J:110241
increased pro-B cell number J:110241
pointed snout J:110241
short face J:110241
Kmt2atm2Sjk/Kmt2a+
Tg(Mx1-cre)1Cgn/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal bone marrow cell morphology/development J:95914
abnormal spleen morphology J:95914
anemia J:95914
enlarged spleen J:95914
increased incidence of induced tumors J:95914
increased leukocyte cell number J:95914
increased mortality induced by gamma-irradiation J:95914
increased spleen red pulp amount J:95914
myeloid hyperplasia J:95914
thrombocytopenia J:95914
Lmo2tm2(cre)Thr/Lmo2+
Kmt2atm1Thr/Kmt2a+
Mllt1tm1Thr/Mllt1+
involves: 129S/SvEv 		abnormal spleen red pulp morphology J:100794
abnormal spleen white pulp morphology J:100794
enlarged spleen J:84518, J:100794
increased hemolymphoid system tumor incidence J:100794
increased leukemia incidence J:84518, J:100794
pale kidney J:84518
pale liver J:84518
premature death J:84518
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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08/02/2024
MGI 6.24 		The Jackson Laboratory