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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mmp2
matrix metallopeptidase 2
MGI:97009
58 phenotypes from 2 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mmp2em1(IMPC)Mbp/Mmp2em1(IMPC)Mbp
C57BL/6N-Mmp2em1(IMPC)Mbp/MbpMmucd 		abnormal bone structure J:211773
abnormal kidney morphology J:211773
abnormal lymph node morphology J:211773
abnormal retina morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal stomach morphology J:211773
abnormal vitreous body morphology J:211773
cataract J:211773
decreased body length J:211773
decreased bone mineral content J:211773
decreased prepulse inhibition J:211773
enlarged lymph nodes J:211773
enlarged spleen J:211773
enlarged stomach J:211773
increased heart rate J:211773
small kidney J:211773
Mmp2tm1Ito/Mmp2tm1Ito
B6.129P2-Mmp2tm1Ito 		normal neoplasm J:105098
Mmp2tm1Ito/Mmp2tm1Ito
involves: 129P2/OlaHsd 		abnormal articular cartilage morphology J:121780
abnormal bone marrow cell physiology J:121780
abnormal compact bone morphology J:121780
abnormal coronal suture morphology J:121780
abnormal cranium morphology J:121780
abnormal induced retina neovascularization J:113620
abnormal lambdoid suture morphology J:121780
abnormal sagittal suture morphology J:121780
abnormal skeleton development J:121780
abnormal trabecular bone morphology J:121780
autoimmune arthritis J:121780
broad snout J:121780
coronal suture sclerosis J:121780
decreased body size J:121780
decreased bone mineral density J:121780
decreased bone volume J:121780
decreased length of long bones J:121780
decreased osteoblast cell number J:121780
decreased osteoclast cell number J:121780
increased inner canthal distance J:121780
lambdoid suture sclerosis J:121780
sagittal suture sclerosis J:121780
short mandible J:121780
short maxilla J:121780
short snout J:121780
Mmp2tm1Ito/Mmp2tm1Ito
involves: 129P2/OlaHsd * C57BL/6 		impaired lung alveolus development J:97067
Mmp2tm1Ito/Mmp2tm1Ito
involves: 129P2/OlaHsd * C57BL/6J 		abnormal angiogenesis J:101783
abnormal cardiovascular system physiology J:85439
abnormal inflammatory response J:46091
abnormal response to cardiac infarction J:85439
abnormal vascular smooth muscle physiology J:101783
brain inflammation J:94099
decreased angiogenesis J:46091, J:81029
decreased body size J:42742
decreased inflammatory response J:46091
decreased tumor growth/size J:46091
dilated heart left ventricle J:85439
increased susceptibility to experimental autoimmune encephalomyelitis J:94099
postnatal growth retardation J:42742
Mmp2tm1Ito/Mmp2tm1Ito
Not Specified 		no abnormal phenotype detected J:91198
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory