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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Msx2
msh homeobox 2
MGI:97169
101 phenotypes from 8 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Msx2m1Btlr/Msx2m1Btlr
C57BL/6J-Msx2m1Btlr 		abnormal hair shedding J:204501
alopecia J:204501
delayed hair regrowth J:204501
microphthalmia J:204501
Msx2tm1.1Yvla/Msx2tm1.1Yvla
involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL 		abnormal cerebellum development J:136241
abnormal skeleton development J:136241
alopecia J:136241
embryonic growth retardation J:136241
Msx2tm1Rem/Msx2tm1Rem
Tg(Msx2-cre)5Rem/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal neurocranium morphology J:128624
alopecia J:128624
Msx2tm1Rilm/Msx2+
involves: 129S4/SvJae * BALB/c * C57BL/6 		frontal bone foramen J:87044
Msx2tm1Rilm/Msx2tm1Rilm
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6J) 		abnormal appendicular skeleton morphology J:61509
abnormal axial skeleton morphology J:61509
abnormal bone ossification J:61509
abnormal cerebellum anterior vermis morphology J:61509
abnormal cerebellum development J:61509
abnormal enamel organ morphology J:61509
abnormal long bone hypertrophic chondrocyte zone J:61509
abnormal mammary gland embryonic development J:61509
abnormal neurocranium morphology J:61509
abnormal stellate reticulum morphology J:61509
abnormal stratum intermedium morphology J:61509
abnormal trabecular bone morphology J:61509
absent cerebellum vermis lobule IX J:61509
absent cerebellum vermis lobule VIII J:61509
alopecia J:61509
ameloblast degeneration J:61509
normal behavior/neurological phenotype J:61509
big ears J:61509
brittle teeth J:61509
cerebellum vermis hypoplasia J:61509
chondrodystrophy J:61509
curly vibrissae J:73670
decreased bone mineral density J:61509
decreased chondrocyte number J:61509
decreased compact bone thickness J:61509
decreased osteoclast cell number J:61509
degenerate molars J:61509
delaminated cerebellar granule layer J:61509
delaminated Purkinje cell layer J:61509
frontal bone foramen J:61509
normal integument phenotype J:73670
long nails J:61509
malocclusion J:61509
normal mortality/aging J:61509
normal nervous system phenotype J:61509
premature hair loss J:61509
short femur J:61509
short tibia J:61509
short vibrissae J:73670
small interparietal bone J:61509
small supraoccipital bone J:61509
tonic seizures J:61509
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae 		abnormal cornea morphology J:184697
abnormal eye development J:184697
abnormal eye morphology J:184697
abnormal lens morphology J:184697
abnormal lens vesicle development J:184697
abnormal optic vesicle formation J:184697
abnormal retina pigment epithelium morphology J:184697
anterior iris synechia J:184697
cornea opacity J:184697
decreased cornea epithelium thickness J:184697
increased cornea stroma thickness J:184697
increased cornea thickness J:184697
iris hyperplasia J:184697
microphthalmia J:184697
narrow eye opening J:184697
retina fold J:184697
small lens J:184697
vitreous body deposition J:184697
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae * BALB/c * C57BL/6 		abnormal frontal bone morphology J:87044
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae * BALB/c * CD-1 		normal cardiovascular system phenotype J:139946
Msx2tm1Rilm/Msx2tm1Rilm
involves: 129S4/SvJae * CD-1 		abnormal nail matrix morphology J:173664
abnormal nail morphology J:173664
deformed nails J:173664
long toenails J:173664
Msx2tm1Yvla/Msx2tm1Yvla
involves: 129S2/SvPas * C57BL/6 * SJL 		no abnormal phenotype detected J:136241
Tg(CMV-Msx2*P7H)1Rem/0
involves: C57BL/6 * CBA/J 		ectopic cranial bone J:26513
premature cranial suture closure J:26513
Tg(Msx2)1Rem/0
involves: C57BL/6 * CBA/J 		abnormal coat/ hair morphology J:56777
abnormal dermal layer morphology J:56777
abnormal ear morphology J:26513
abnormal epidermal layer morphology J:56777
abnormal epidermis stratum basale morphology J:56777
abnormal eye morphology J:26513
abnormal hair follicle bulb morphology J:56777
abnormal hair follicle inner root sheath morphology J:56777
abnormal hair follicle matrix region morphology J:56777
abnormal hair follicle morphology J:56777
abnormal hair follicle orientation J:56777
abnormal hair shaft morphology J:56777
abnormal skin morphology J:56777
dermis papillary layer hypercellularity J:56777
disorganized inner root sheath cells J:56777
disorganized matrix sheath cells J:56777
disorganized outer root sheath cells J:56777
disorganized suprabasal layer J:56777
distorted hair follicle pattern J:56777
ectopic cranial bone J:26513
epidermal desquamation J:56777
flaky skin J:56777
focal hair loss J:56777
hyperkeratosis J:56777
premature cranial suture closure J:26513
scaly skin J:56777
short hair J:56777
thick epidermis J:56777
thick epidermis suprabasal layer J:56777
thick skin J:56777
thin hair follicle outer root sheath J:56777
Tg(Timp1-Msx2*P7H)1Rem/0
involves: C57BL/6 * CBA/J 		premature cranial suture closure J:26513
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory