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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mt1
metallothionein 1
MGI:97171
88 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atp7aMo-brJ/Atp7a+
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
involves: 129S7/SvEvBrd * C3H/HeJ 		decreased body size J:33276
embryonic lethality, complete penetrance J:33276
normal homeostasis/metabolism phenotype J:33276
increased sensitivity to induced cell death J:33276
Atp7aMo-brJ/Atp7a+
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
Tg(Mt1)174Bri/0
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6 * SJL 		no abnormal phenotype detected J:33276
Atp7aMo-brJ/Y
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J 		embryonic lethality during organogenesis, incomplete penetrance J:33276
increased sensitivity to induced cell death J:33276
postnatal lethality, complete penetrance J:33276
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri 		abnormal circulating enzyme level J:16487
abnormal liver morphology J:16487
hepatic necrosis J:16487
increased circulating alkaline phosphatase level J:16487
liver degeneration J:16487
premature death J:16487
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
129S7/SvEvBrd-Mt1tm1Bri Mt2tm1Bri/J 		abnormal astrocyte morphology J:89429
abnormal compact bone morphology J:126420
abnormal humoral immune response J:110643
abnormal learning/memory/conditioning J:112813
abnormal long bone epiphyseal ossification zone morphology J:126420
abnormal long bone epiphyseal plate morphology J:126420
abnormal lymphocyte physiology J:110643
abnormal microglial cell morphology J:89429
abnormal physiological response to xenobiotic J:56770, J:126620
abnormal reproductive system physiology J:103039
abnormal trabecular bone morphology J:126420
abnormal zinc homeostasis J:89429
clonic seizures J:89429
decreased B cell number J:110643
decreased bone mass J:126420
decreased bone mineral content J:126420
decreased compact bone thickness J:126420
decreased hepatocyte proliferation J:109814
decreased T cell number J:110643
dilated kidney collecting duct J:126620
dilated proximal convoluted tubule J:126620
enlarged kidney J:126620
enlarged liver J:126620
enlarged spleen J:110643
normal homeostasis/metabolism phenotype J:59769
impaired liver regeneration J:109814
increased blood urea nitrogen level J:126620
increased CD4-positive, alpha-beta T cell number J:110643
increased CD8-positive, alpha-beta T cell number J:110643
increased IgG level J:110643
increased IgM level J:110643
increased incidence of tumors by chemical induction J:56770
increased lymphocyte cell number J:110643
increased neuron apoptosis J:89429
increased neutrophil cell number J:120196
increased physiological sensitivity to xenobiotic J:89429, J:126420, J:126620
increased plasma cell number J:110643
increased renal tubule apoptosis J:126620
increased spleen weight J:110643
increased susceptibility to injury J:62369
increased susceptibility to pharmacologically induced seizures J:89429
increased susceptibility to xenobiotic induced morbidity/mortality J:120196
increased thymocyte apoptosis J:57169
increased urine glucose level J:126620
kidney atrophy J:126620
kidney degeneration J:126620
kidney inflammation J:126620
lung inflammation J:120196
nephrocalcinosis J:126620
renal interstitial fibrosis J:126620
renal necrosis J:126620
spleen hyperplasia J:110643
tonic-clonic seizures J:89429
weight loss J:126420
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
involves: 129S7/SvEvBrd 		abnormal hepatocyte morphology J:120459
abnormal lipid homeostasis J:120459
abnormal liver zinc level J:34407
abnormal microglial cell morphology J:53929, J:103102
abnormal microglial cell physiology J:53929
abnormal pancreas morphology J:34407
abnormal renal glomerulus morphology J:34407
abnormal zinc homeostasis J:34407
astrocytosis J:53929, J:103102
hemorrhage J:53929
hepatic necrosis J:120459
normal homeostasis/metabolism phenotype J:33276
impaired wound healing J:53929
increased brain apoptosis J:53929
increased circulating alanine transaminase level J:120459
increased glomerular capsule space J:34407
increased interleukin-1 beta secretion J:103102
increased interleukin-6 secretion J:103102
increased macrophage cell number J:53929
increased neuron apoptosis J:103102
increased physiological sensitivity to xenobiotic J:120459
increased sensitivity to induced cell death J:33276
increased susceptibility to experimental autoimmune encephalomyelitis J:103102
increased susceptibility to xenobiotic induced morbidity/mortality J:120459
increased tumor necrosis factor secretion J:103102
oxidative stress J:103102
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
involves: 129S7/SvEvBrd * C57BL/6 		abnormal intestinal mineral absorption J:47419
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
involves: 129S7/SvEvBrd * C57BL/6J 		abnormal retina ganglion layer morphology J:116275
increased physiological sensitivity to xenobiotic J:116275
Mt1tm1Bri/Mt1tm1Bri
Mt2tm1Bri/Mt2tm1Bri
involves: 129S7/SvEvBrd * CD-1 		abnormal zinc homeostasis J:103039
Mt1tm1Rch/Mt1tm1Rch
Mt2tm1Rch/Mt2tm1Rch
involves: 129P2/OlaHsd * C57BL/6J 		abnormal hepatocyte morphology J:120459
abnormal ion homeostasis J:14416
abnormal lipid homeostasis J:120459
hepatic necrosis J:120459
increased circulating alanine transaminase level J:120459
increased incidence of tumors by chemical induction J:120459
increased physiological sensitivity to xenobiotic J:120459
increased susceptibility to xenobiotic induced morbidity/mortality J:120459
increased tumor incidence J:84369
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/19/2024
MGI 6.24 		The Jackson Laboratory