Mapt Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mapt
microtubule-associated protein tau
MGI:97180

23 phenotypes from 12 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chat^tm2(cre)Lowl/Chat⁺ Mapt^{tm3(Sema3e)Arbr}/Mapt^{tm3(Sema3e)Arbr} involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	abnormal motor neuron innervation pattern	J:149553
	normal behavior/neurological phenotype	J:149553
Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt B6.129S4-Mapt^tm1(EGFP)Klt	abnormal motor learning	J:213115
	enhanced spatial learning	J:213115
	impaired contextual conditioning behavior	J:213115
	impaired cued conditioning behavior	J:213115
	reduced long-term potentiation	J:213115
Mapt^tm1(EGFP)Klt/Mapt^tm1(EGFP)Klt involves: 129S4/SvJae * C57BL/6	normal behavior/neurological phenotype	J:169074
	no abnormal phenotype detected	J:66561
Mapt^{tm1(Setdb1)Akba}/Mapt^{tm1(Setdb1)Akba} involves: 129S7/SvEvBrd * C57BL/6J	normal behavior/neurological phenotype	J:178512
	normal mortality/aging	J:178512
Mapt^{tm1.1(MAPT)Tcs}/Mapt^{tm1.1(MAPT)Tcs} B6.Cg-Mapt^{tm1.1(MAPT)Tcs}	normal nervous system phenotype	J:278451
Mapt^tm1.1Cole/Mapt^tm1.1Cole involves: C57BL/6J * C57BL/6JOlaHsd	normal behavior/neurological phenotype	J:188213
Mapt^tm1Aha/Mapt^tm1Aha Not Specified	abnormal axon morphology	J:123734
Mapt^{tm1b(EUCOMM)Hmgu}/Mapt^{tm1b(EUCOMM)Hmgu} C57BL/6N-Mapt^{tm1b(EUCOMM)Hmgu}/Ics	abnormal retina blood vessel morphology	J:211773
	abnormal retina vasculature morphology	J:211773
	decreased exploration in new environment	J:211773
	decreased grip strength	J:211773
	decreased total retina thickness	J:211773
	increased fluid intake	J:211773
	persistence of hyaloid vascular system	J:211773
	polycystic kidney	J:211773
Mapt^tm1Hnd/Mapt⁺ involves: 129X1/SvJ * C57BL/6	decreased susceptibility to pharmacologically induced seizures	J:121330
Mapt^tm1Hnd/Mapt^tm1Hnd involves: 129X1/SvJ * C57BL/6	abnormal axon extension	J:78649
	abnormal dendrite morphology	J:78649
	decreased susceptibility to pharmacologically induced seizures	J:121330
Mapt^tm1Noh/Mapt^tm1Noh involves: 129S4/SvJae	abnormal axon morphology	J:19030
Mapt^tm2(cre)Aha/Mapt^tm2(cre)Aha Not Specified	normal nervous system phenotype	J:134499
Mapt^tm2Arbr/Mapt⁺ Pvalb^tm1(cre)Arbr/Pvalb⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal dorsal root ganglion morphology	J:100886
Mapt^{tm3(cre/PGR)Aha}/Mapt^{tm3(cre/PGR)Aha} Not Specified	no abnormal phenotype detected	J:136624

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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