About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mapt
microtubule-associated protein tau
MGI:97180
100 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Apptm3.1Tcs/Apptm3.1Tcs
Mapttm1.1(MAPT)Tcs/Mapttm1.1(MAPT)Tcs
involves: 129S/SvEv * C57BL/6 		amyloid beta deposits J:278451
CNS inflammation J:278451
increased neuron apoptosis J:278451
Bdnftm1Msd/Bdnftm1Msd
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ 		normal mortality/aging J:131394
normal nervous system phenotype J:131394
reduced long-term potentiation J:131394
Bdnftm1Yab/Bdnftm1Yab
Mapttm1(cre)Nagy/Mapt+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal dendrite morphology J:157932
abnormal locomotor activation J:157932
abnormal neuron morphology J:157932
abnormal optic nerve morphology J:157932
decreased body weight J:157932
decreased brain size J:157932
decreased brain weight J:157932
decreased striatum size J:157932
increased anxiety-related response J:157932
increased body weight J:157932
limb grasping J:157932
postnatal growth retardation J:157932
postnatal lethality, complete penetrance J:157932
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal axon morphology J:226826
abnormal craniofacial development J:226826
abnormal nociceptor morphology J:226826
abnormal sensory neuron innervation pattern J:226826
perinatal lethality J:226826
Cbfbtm2.1Ddg/Cbfbtm2.1Ddg
Mapttm2Arbr/?
Runx1tm1(cre/Esr1*)Ims/?
involves: 129S6/SvEvTac * C57BL/6NCrlj * CBA/JNCrlj 		abnormal mechanoreceptor morphology J:226826
Chattm2(cre)Lowl/Chat+
Mapttm2(FUS)Neas/Mapt+
B6.129-Mapttm2(FUS)Neas Chattm2(cre)Lowl 		abnormal neuromuscular synapse morphology J:232167
motor neuron degeneration J:232167
Chattm2(cre)Lowl/Chat+
Mapttm3(FUS)Neas/Mapt+
B6.129-Mapttm3(FUS)Neas Chattm2(cre)Lowl 		abnormal neuromuscular synapse morphology J:232167
motor neuron degeneration J:232167
Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi
Mapttm3.1(FUS)Neas/Mapt+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129 * C3H * C57BL/6 * C57BL/6N 		abnormal neuromuscular synapse morphology J:232167
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal dorsal root ganglion morphology J:100886
abnormal sensory neuron innervation pattern J:100886
abnormal sensory neuron morphology J:100886
decreased muscle spindle number J:100886
Kansl1/Mapttm1.1Cole/Kansl1/Mapttm1.1Cole
involves: C57BL/6 * C57BL/6J * C57BL/6JOlaHsd 		abnormal axonal transport J:188213
normal behavior/neurological phenotype J:188213
hyperactivity J:188213
normal nervous system phenotype J:188213
Lbx1tm2Cbm/Lbx1tm3.1(cre)Cbm
Mapttm2Arbr/Mapt+
involves: 129P2/OlaHsd 		abnormal brainstem morphology J:121332
abnormal medulla oblongata morphology J:121332
abnormal neuron differentiation J:121332
abnormal neuron morphology J:121332
abnormal neuron specification J:121332
increased sensory neuron number J:121332
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/0
B6.Cg-Tg(MAPT)8cPdav Mapttm1(EGFP)Klt/J 		abnormal spatial learning J:172426
neurofibrillary tangles J:172426
normal taste/olfaction phenotype J:172426
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(MAPT)8cPdav/?
involves: 129S4/SvJae * C57BL/6 * Swiss Webster 		abnormal neuron morphology J:84638
abnormal renal glomerulus morphology J:174270
abnormal spleen B cell follicle morphology J:174270
abnormal spleen B cell follicle shape J:174270
abnormal spleen red pulp morphology J:174270
amyloidosis J:174270
increased follicular lymphoma incidence J:174270
increased lymphoma incidence J:174270
increased spleen B cell follicle size J:174270
tau protein deposits J:84638
Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt
Tg(Thy1-MAPT*)30Schd/0
involves: 129S4/SvJae * C57BL/6 * CBA 		abnormal brain morphology J:169074
abnormal sciatic nerve morphology J:169074
abnormal spinal cord morphology J:169074
normal behavior/neurological phenotype J:169074
impaired coordination J:169074
normal nervous system phenotype J:169074
neurofibrillary tangles J:169074
premature death J:169074
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Mnx1tm4(cre)Tmj/Mnx1+
involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 		abnormal axon extension J:100886
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
FVB.Cg-Mapttm1(MAPT)Vln 		abnormal motor coordination/balance J:96869
normal nervous system phenotype J:96869
Mapttm1(MAPT)Vln/Mapttm1(MAPT)Vln
involves: FVB/N 		abnormal axon extension J:129032
abnormal dendrite morphology J:129032
abnormal hippocampus pyramidal cell morphology J:129032
decreased anxiety-related response J:129032
enhanced long-term object recognition memory J:129032
enlarged hippocampus J:129032
increased cell proliferation J:129032
Mapttm1(Mecp2)Jae/Mapt+
involves: 129/Sv * C57BL/6 		no abnormal phenotype detected J:89593
Mapttm1(Mecp2)Jae/Mapt+
Mecp2tm1.1Jae/Mecp2+
involves: 129S4/SvJae * C57BL/6 		normal behavior/neurological phenotype J:89593
normal growth/size/body region phenotype J:89593
normal nervous system phenotype J:89593
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
B6.Cg-Mapttm1(Mecp2)Jae 		abnormal associative learning J:182685
abnormal contextual conditioning behavior J:182685
abnormal cued conditioning behavior J:182685
abnormal miniature excitatory postsynaptic currents J:182685
abnormal object recognition memory J:182685
decreased body weight J:182685
enhanced paired-pulse facilitation J:182685
impaired coordination J:182685
increased anxiety-related response J:182685
reduced long-term potentiation J:182685
Mapttm1(Mecp2)Jae/Mapttm1(Mecp2)Jae
involves: 129/Sv * C57BL/6 		abnormal sexual interaction J:89593
ataxia J:89593
cachexia J:89593
cataract J:89593
disheveled coat J:89593
excessive scratching J:89593
impaired balance J:89593
normal mortality/aging J:89593
postnatal growth retardation J:89593
tremors J:89593
Mapttm1(Sema3e)Yuyo/Mapt+
Olig2tm1(cre)Tmj/Olig2+
Not Specified 		abnormal excitatory postsynaptic potential J:205528
abnormal sensory neuron innervation pattern J:205528
abnormal synaptic bouton morphology J:205528
normal nervous system phenotype J:205528
Mapttm1(Setdb1)Akba/Mapt+
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N 		impaired coordination J:178512
premature death J:178512
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N 		impaired coordination J:178512
premature death J:178512
Mapttm1.1(FUS)Neas/Mapt+
B6J.129P2(129S)-Mapttm1.1(FUS)Neas 		normal nervous system phenotype J:232167
Mapttm1.1(FUS)Neas/Mapttm1.1(FUS)Neas
B6J.129P2(129S)-Mapttm1.1(FUS)Neas 		normal nervous system phenotype J:232167
Mapttm1Hnd/Mapt+
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 		abnormal neuron differentiation J:121330
abnormal neuron morphology J:121330
abnormal spatial learning J:121330
amyloid beta deposits J:121330
normal behavior/neurological phenotype J:121330
decreased susceptibility to pharmacologically induced seizures J:121330
Mapttm1Hnd/Mapttm1Hnd
Zbtb20Tg(PDGFB-APPSwInd)20Lms/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 		abnormal neuron differentiation J:121330
abnormal neuron morphology J:121330
amyloid beta deposits J:121330
normal behavior/neurological phenotype J:121330
decreased susceptibility to pharmacologically induced seizures J:121330
Mapttm2(Hdac1)Jae/Mapttm2(Hdac1)Jae
involves: 129S4/SvJae * C57BL/6 		abnormal hippocampus pyramidal cell morphology J:148391
Mapttm2.1(FUS)Neas/Mapt+
B6J.129P2(129S)-Mapttm2.1(FUS)Neas 		abnormal motor neuron innervation pattern J:232167
abnormal neuromuscular synapse morphology J:232167
astrocytosis J:232167
microgliosis J:232167
motor neuron degeneration J:232167
Mapttm2.1(RHOA*)Klt/Mapt+
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal somatosensory cortex morphology J:159220
decreased neuron apoptosis J:159220
increased neuron number J:159220
normal nervous system phenotype J:159220
Mapttm2Arbr/Mapt+
Neurod6tm1(cre)Kan/Neurod6+
Trim67tm1.1Slgu/Trim67tm1.1Slgu
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 		decreased corpus callosum size J:266702
Mapttm2Arbr/Mapt+
Shox2tm1.1(cre)Oki/Shox2+
Slc17a6tm1.1Thna/Slc17a6tm1.2Edw
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J 		abnormal nervous system physiology J:209344
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm1(cre/Esr1*)Ims
involves: 129S4/SvJae * C57BL/6NCrlj * CBA/JNCrlj 		abnormal mechanoreceptor morphology J:226826
Mapttm2Arbr/?
Runx1tm3Spe/Runx1tm3Spe
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * CBA/J 		abnormal axon morphology J:226826
abnormal sensory neuron innervation pattern J:226826
Mapttm3(Hdac2)Jae/Mapttm3(Hdac2)Jae
involves: 129S4/SvJae * C57BL/6 		abnormal dentate gyrus morphology J:148391
abnormal hippocampus CA1 region morphology J:148391
abnormal hippocampus pyramidal cell morphology J:148391
abnormal spatial learning J:148391
abnormal spatial working memory J:148391
impaired contextual conditioning behavior J:148391
reduced long-term potentiation J:148391
Mapttm3.1(FUS)Neas/Mapt+
B6J.129P2(129S)-Mapttm3.1(FUS)Neas 		abnormal motor neuron innervation pattern J:232167
abnormal neuromuscular synapse morphology J:232167
abnormal sarcomere morphology J:232167
abnormal synaptic bouton morphology J:232167
abnormal synaptic depression J:232167
abnormal synaptic transmission J:232167
abnormal tibialis anterior morphology J:232167
astrocytosis J:232167
microgliosis J:232167
motor neuron degeneration J:232167
paraparesis J:232167
Mapttm3.1(FUS)Neas/Mapttm3.1(FUS)Neas
B6J.129P2(129S)-Mapttm3.1(FUS)Neas 		abnormal neuromuscular synapse morphology J:232167
Smc3tm1.1Toshi/Smc3+
Mapttm2(cre)Aha/Mapt+
involves: C57BL/6J 		decreased CNS synapse formation J:242006
increased anxiety-related response J:242006
Smc3tm1.1Toshi/Smc3tm1.1Toshi
Mapttm2(cre)Aha/?
involves: C57BL/6J 		decreased body size J:242006
postnatal growth retardation J:242006
premature death J:242006
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory