Myl1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Myl1
myosin, light polypeptide 1
MGI:97269

65 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Atad3a^{tm1c(KOMP)Wtsi}/Atad3a^{tm1c(KOMP)Wtsi} Myl1^tm1(cre)Sjb/Myl1⁺ B6J.Cg-Myl1^tm1(cre)Sjb Atad3a^{tm1c(KOMP)Wtsi}	abnormal cholesterol homeostasis	J:263681
	abnormal mitochondrial crista morphology	J:263681
	abnormal motor coordination/balance	J:263681
	abnormal muscle fiber mitochondrial morphology	J:263681
	abnormal muscle fiber morphology	J:263681
	abnormal oxidative phosphorylation	J:263681
	cachexia	J:263681
	decreased grip strength	J:263681
	decreased locomotor activity	J:263681
	decreased mitochondrial size	J:263681
	decreased skeletal muscle fiber mitochondrial DNA content	J:263681
	decreased skeletal muscle weight	J:263681
	disorganized mitochondrial cristae	J:263681
	normal growth/size/body region phenotype	J:263681
	kyphosis	J:263681
	skeletal muscle fiber atrophy	J:263681
	skeletal muscle fiber degeneration	J:263681
	weakness	J:263681
Cox10^tm1Ctm/Cox10^tm1Ctm Myl1^tm1(cre)Sjb/Myl1⁺ involves: 129X1/SvJ * C57BL/6	abnormal skeletal muscle morphology	J:101747
	decreased locomotor activity	J:101747
	decreased skeletal muscle mass	J:101747
	increased muscle fatigability	J:101747
	increased variability of skeletal muscle fiber size	J:101747
	kyphosis	J:101747
	myopathy	J:101747
	premature death	J:101747
	weight loss	J:101747
Hprt1^{tm1(CAG-Gys1)Jjg}/? Myl1^tm1(cre)Sjb/Myl1⁺ involves: 129P2/OlaHsd 129S1/Sv * 129X1/SvJ	abnormal cellular respiration	J:244440
	abnormal response to exercise	J:244440
	decreased aerobic running capacity	J:244440
	impaired exercise endurance	J:244440
	increased skeletal muscle glycogen level	J:244440
Myl1^tm1(cre)Sjb/Myl1⁺ Tfam^tm1Lrsn/Tfam^tm1Lrsn involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal respiratory electron transport chain	J:81561
	bradykinesia	J:81561
	impaired skeletal muscle contractility	J:81561
	increased skeletal muscle fiber size	J:81561
	premature death	J:81561
	weight loss	J:81561
Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm3Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	abnormal locomotor coordination	J:122927
	decreased muscle spindle number	J:122927
	impaired limb coordination	J:122927
Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm4Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	abnormal locomotor coordination	J:122927
	abnormal muscle spindle morphology	J:122927
	ataxia	J:122927
Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm7Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	abnormal locomotor coordination	J:122927
	ataxia	J:122927
	decreased muscle spindle number	J:122927
	impaired limb coordination	J:122927
Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm9Paw/Shc1^tm9Paw involves: 129S1/Sv * 129X1/SvJ	abnormal locomotor coordination	J:122927
	ataxia	J:122927
	decreased muscle spindle number	J:122927
	impaired limb coordination	J:122927
Myl1^tm1(cre)Sjb/Myl1⁺ Smarcd3^tm1Jddl/Smarcd3^tm1Jddl involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal muscle physiology	J:256788
	normal growth/size/body region phenotype	J:256788
	impaired glucose tolerance	J:256788
	increased circulating glucose level	J:256788
	insulin resistance	J:256788
Myl1^tm1(cre)Sjb/0 Ndufab1^tm1Xiwa/Ndufab1^tm1Xiwa involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6	decreased body size	J:293657
	decreased circulating insulin level	J:293657
	decreased liver glycogen level	J:293657
	decreased skeletal muscle glycogen level	J:293657
	disorganized mitochondrial cristae	J:293657
	normal homeostasis/metabolism phenotype	J:293657
	hypoglycemia	J:293657
	normal muscle phenotype	J:293657
	postnatal growth retardation	J:293657
	preweaning lethality, complete penetrance	J:293657
Ralgapa1^{tm2c(KOMP)Wtsi}/Ralgapa1^{tm2c(KOMP)Wtsi} Myl1^tm1(cre)Sjb/Myl1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N	abnormal lipid homeostasis	J:287672
	improved glucose tolerance	J:287672
	increased circulating cholesterol level	J:287672
	increased circulating free fatty acids level	J:287672
	increased circulating insulin level	J:287672
	increased circulating triglyceride level	J:287672
	increased muscle cell glucose uptake	J:287672
Trp53inp2^tm1Azo/Trp53inp2^tm1Azo Myl1^tm1(cre)Sjb/Myl1⁺ involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal skeletal muscle morphology	J:212763
	decreased physiological sensitivity to xenobiotic	J:212763
	normal homeostasis/metabolism phenotype	J:212763
	impaired autophagy	J:212763
	increased lean body mass	J:212763
	increased skeletal muscle fiber diameter	J:212763
	increased skeletal muscle weight	J:212763
	skeletal muscle hypertrophy	J:212763

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24