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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myl2
myosin, light polypeptide 2, regulatory, cardiac, slow
MGI:97272
42 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Myl2tm1(Hand1)Tana/Myl2+
involves: 129X1/SvJ * C57BL/6J 		abnormal heart development J:91082
abnormal interventricular groove morphology J:91082
common ventricle J:91082
embryonic growth retardation J:91082
lethality throughout fetal growth and development, complete penetrance J:91082
thin myocardium compact layer J:91082
Myl2tm1.1Chen/Myl2tm1.1Chen
B6.129-Myl2tm1.1Chen 		normal cardiovascular system phenotype J:184548
normal mortality/aging J:184548
Myl2tm1b(EUCOMM)Hmgu/Myl2+
C57BL/6N-Myl2tm1b(EUCOMM)Hmgu/Ieg 		absent vibrissae J:211773
decreased circulating alkaline phosphatase level J:211773
increased total body fat amount J:211773
Myl2tm1b(EUCOMM)Hmgu/Myl2tm1b(EUCOMM)Hmgu
C57BL/6N-Myl2tm1b(EUCOMM)Hmgu/Ieg 		preweaning lethality, complete penetrance J:211773
Myl2tm2.1Chen/Myl2tm2.1Chen
B6.129-Myl2tm2.1Chen 		abnormal myocardial fiber physiology J:184548
abnormal Z line morphology J:184548
cardiac fibrosis J:184548
congestive heart failure J:184548
decreased heart ventricle muscle contractility J:184548
dilated cardiomyopathy J:184548
dilated heart ventricle J:184548
dystrophic cardiac calcinosis J:184548
increased heart left ventricle size J:184548
increased heart weight J:184548
increased myocardial fiber size J:184548
increased response of heart to induced stress J:184548
premature death J:184548
thin interventricular septum J:184548
Tg(Myh6-Myl2*)21Rbns/0
Not Specified 		abnormal cardiac muscle contractility J:114298
abnormal cardiac muscle relaxation J:114298
abnormal cardiovascular system physiology J:114298
abnormal heart septum morphology J:114298
abnormal intercalated disk morphology J:114298
abnormal myocardial fiber morphology J:114298
abnormal myocardial fiber physiology J:114298
abnormal sarcomere morphology J:114298
cardiac hypertrophy J:114298
decreased cardiac muscle contractility J:110993
decreased left ventricle developed pressure J:110993
decreased systemic arterial systolic blood pressure J:110993
dilated heart atrium J:114298
dilated heart right ventricle J:114298
increased heart atrium size J:114298
myocardial fiber degeneration J:114298
tricuspid valve regurgitation J:114298
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory