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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Myl2
myosin, light polypeptide 2, regulatory, cardiac, slow
MGI:97272
105 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atg5tm1Myok/Atg5tm1Myok
Myl2tm1(cre)Krc/Myl2+
involves: 129S/SvEv * 129S4/SvJae 		abnormal cardiovascular system physiology J:121778
congestive heart failure J:121778
dilated heart left ventricle J:121778
increased physiological sensitivity to xenobiotic J:121778
increased susceptibility to induced morbidity/mortality J:121778
Atp1b1tm1.1Akra/Atp1b1tm1.1Akra
Myl2tm1(cre)Krc/Myl2+
involves: 129S/SvEv * 129S4/SvJae 		abnormal cardiac muscle contractility J:152596
abnormal myocardial fiber physiology J:152596
cardiac hypertrophy J:152596
decreased heart ventricle muscle contractility J:152596
decreased physiological sensitivity to xenobiotic J:152596
increased heart weight J:152596
increased response of heart to induced stress J:152596
increased susceptibility to induced morbidity/mortality J:152596
Atp2a2tm1.1Iemr/Atp2a2+
Myl2tm1(cre)Krc/Myl2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6Crl * C57BL/6J 		normal cardiovascular system phenotype J:155628
Cacnb2tm1Mfre/Cacnb2tm1.1Mfre
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N 		abnormal myocardial fiber physiology J:126506
abnormal vitelline vascular remodeling J:126506
decreased heart rate J:126506
embryonic lethality during organogenesis, complete penetrance J:126506
Dag1tm2Kcam/Dag1tm2Kcam
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ 		abnormal cardiac muscle contractility J:169951
abnormal heart left ventricle wall thickness J:169951
cardiac fibrosis J:169951
dilated cardiomyopathy J:169951
myocardial fiber degeneration J:169951
Dsptm1Efu/Dsptm1Efu
Myl2tm1(cre)Krc/Myl2+
involves: 129 * 129S4/SvJae * C57BL/6 		abnormal heart morphology J:205990
abnormal impulse conducting system conduction J:205990
abnormal intercalated disk morphology J:205990
abnormal myocardial fiber morphology J:205990
abnormal myocardium layer morphology J:205990
abnormal subendocardium layer morphology J:205990
abnormal Z line morphology J:205990
bundle branch block J:205990
cardiac fibrosis J:205990
decreased heart ventricle muscle contractility J:205990
dilated heart ventricle J:205990
enlarged heart J:205990
increased apoptosis J:205990
increased heart atrium size J:205990
increased susceptibility to induced morbidity/mortality J:205990
irregular heartbeat J:205990
premature death J:205990
prolonged QRS complex duration J:205990
ventricular cardiomyopathy J:205990
ventricular premature beat J:205990
Egln1tm1.1Brei/Egln1tm1.1Brei
Myl2tm1(cre)Krc/Myl2+
B6.Cg-Myl2tm1(cre)Krc Egln1tm1.1Brei 		abnormal coronary vessel morphology J:170943
abnormal response to cardiac infarction J:170943
normal cardiovascular system phenotype J:170943
decreased cardiomyocyte apoptosis J:170943
decreased myocardial infarct size J:170943
Erbb2tm1Cbm/Erbb2tm2Cbm
Myl2tm1(cre)Krc/Myl2+
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal myocardial fiber morphology J:77347
cardiac hypertrophy J:77347
decreased heart left ventricle muscle contractility J:77347
decreased heart ventricle muscle contractility J:77347
dilated cardiomyopathy J:77347
increased heart ventricle size J:77347
postnatal lethality, incomplete penetrance J:77347
premature death J:77347
prolonged QT interval J:77347
thin ventricular wall J:77347
Erbb2tm1Klee/Erbb2tm1Klee
Myl2tm1(cre)Krc/Myl2+
involves: 129S4/SvJae 		abnormal cardiac muscle relaxation J:76196
abnormal heart ventricle morphology J:76196
abnormal myocardial fiber morphology J:76196
decreased heart left ventricle posterior wall thickness J:76196
decreased heart left ventricle septal wall thickness J:76196
decreased heart ventricle muscle contractility J:76196
dilated cardiomyopathy J:76196
increased susceptibility to induced morbidity/mortality J:76196
Erbb4tm1Htig/Erbb4tm1Htig
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal impulse conducting system conduction J:101252
abnormal intercalated disk morphology J:101252
abnormal myocardial fiber morphology J:101252
cardiac hypertrophy J:101252
decreased heart left ventricle muscle contractility J:101252
decreased myocardial fiber number J:101252
dilated cardiomyopathy J:101252
dilated heart left ventricle J:101252
dilated heart right ventricle J:101252
enlarged heart J:101252
premature death J:101252
prolonged QRS complex duration J:101252
prolonged QT interval J:101252
thin ventricular wall J:101252
ventricular tachycardia J:101252
F3tm1Nmk/F3tm1Nmk
Myl2tm1(cre)Krc/?
involves: 129S4/SvJae * 129S6/SvEvTac 		cardiac fibrosis J:137921
F3tm1Nmk/F3tm1Nmk
Myl2tm1(cre)Krc/?
Tg(Myh6-F3)4Nmk/?
involves: 129S4/SvJae * 129S6/SvEvTac * BALB/c * C57BL/6 		normal cardiovascular system phenotype J:137921
Fgfr1tm1Upir/Fgfr1tm1Upir
Fgfr2tm1Dor/Fgfr2tm1Dor
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		heart hypoplasia J:131577
thin ventricular wall J:131577
Gja1tm1Gfi/Gja1tm1Gfi
Myl2tm1(cre)Krc/Myl2+
Not Specified 		premature death J:91971
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Myl2tm1(cre)Krc/Myl2+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL 		decreased response of heart to induced stress J:77461
heart hypoplasia J:77461
perinatal lethality, incomplete penetrance J:77461
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * C57BL/6 		heart hypoplasia J:131577
thin ventricular wall J:131577
Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor/Gt(ROSA)26Sortm1(Cdkn1b,EGFP)Dor
Myl2tm1(cre)Krc/Myl2+
involves: 129/Sv * 129S4/SvJae * C57BL/6 		heart hypoplasia J:131577
thin ventricular wall J:131577
Gt(ROSA)26Sortm1(Cdkn1c)Jfpa/Gt(ROSA)26Sor+
Myl2tm1(cre)Krc/Myl2+
involves: 129S7/SvEvBrd * C57BL/6 		abnormal heart left ventricle pressure J:197451
decreased myocardial infarct size J:197451
increased coronary flow rate J:197451
Hcn4tm1Jsr/Hcn4tm1Jsr
Myl2tm1(cre)Krc/Myl2+
involves: 129 		embryonic lethality during organogenesis, complete penetrance J:86988
Hif1atm3Rsjo/Hif1atm3Rsjo
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		abnormal cardiac muscle relaxation J:118455
abnormal coronary vessel morphology J:118455
abnormal heart left ventricle morphology J:118455
abnormal heart left ventricle pressure J:118455
abnormal myocardial fiber physiology J:118455
abnormal physiological response to xenobiotic J:118455
cardiac hypertrophy J:118455
decreased cardiac muscle contractility J:118455
increased heart left ventricle wall thickness J:118455
increased heart left ventricle weight J:118455
thick interventricular septum J:118455
Itgb1tm1Ross/Itgb1tm1Ross
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss 		abnormal atrial thrombosis J:82534
abnormal cardiac muscle cell glucose uptake J:82534
abnormal cardiac muscle relaxation J:82534
abnormal heart ventricle morphology J:82534
abnormal myocardial fiber morphology J:82534
abnormal myocardium layer morphology J:82534
cardiac fibrosis J:82534
congestive heart failure J:82534
decreased heart left ventricle muscle contractility J:82534
dilated cardiomyopathy J:82534
dilated heart J:82534
dilated heart left ventricle J:82534
dilated heart right ventricle J:82534
increased heart atrium size J:82534
increased response of heart to induced stress J:82534
increased susceptibility to induced morbidity/mortality J:82534
liver vascular congestion J:82534
pleural effusion J:82534
thick ventricular wall J:82534
Ldb3tm4Chen/Ldb3tm4Chen
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss 		abnormal heart left ventricle morphology J:144739
abnormal heart right ventricle morphology J:144739
abnormal heart ventricle morphology J:144739
abnormal myocardial fiber morphology J:144739
atrioventricular block J:144739
cardiac hypertrophy J:144739
dilated cardiomyopathy J:144739
enlarged heart J:144739
increased heart weight J:144739
premature death J:144739
thin interventricular septum J:144739
thin ventricular wall J:144739
Lims1tm1.1Chen/Lims1tm1.1Chen
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss 		normal cardiovascular system phenotype J:97635
Mef2ctm1Eno/Mef2ctm1Jjs
Myl2tm1(cre)Krc/Myl2+
involves: 129S4/SvJae * 129S6/SvEvTac * 129S7/SvEvBrd 		no abnormal phenotype detected J:100949
Mfn2tm1.1Mzhe/Mfn2tm1.1Mzhe
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J 		abnormal autophagy J:188865
abnormal cellular respiration J:188865
abnormal mitochondrial morphology J:188865
abnormal myocardial fiber morphology J:188865
abnormal myocardial fiber physiology J:188865
decreased heart ventricle muscle contractility J:188865
increased fetal cardiomyocyte apoptosis J:188865
increased response of heart to induced stress J:188865
lipofuscinosis J:188865
Myl2tm1(cre)Krc/Myl2+
Rxratm1Krc/Rxratm1Krc
involves: 129S4/SvJae * Black Swiss 		no abnormal phenotype detected J:48085
Myl2tm1(cre)Krc/Myl2+
Tsc1tm1Djk/Tsc1tm1Djk
involves: 129S4/SvJae 		abnormal atrial thrombosis J:96138
abnormal myocardial fiber morphology J:96138
decreased cardiac muscle contractility J:96138
dilated cardiomyopathy J:96138
increased myocardial fiber size J:96138
premature death J:96138
pulmonary vascular congestion J:96138
Myl2tm1(cre)Krc/Myl2+
Srsf2tm1Xdfu/Srsf2tm1Xdfu
involves: 129S4/SvJae 		cardiac interstitial fibrosis J:88432
normal cardiovascular system phenotype J:88432
decreased heart left ventricle muscle contractility J:88432
decreased heart ventricle muscle contractility J:88432
dilated cardiomyopathy J:88432
pregnancy-related premature death J:88432
Myl2tm1(cre)Krc/Myl2+
Nkx2-5tm1Krc/Nkx2-5tm1Krc
either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6) 		abnormal atrioventricular bundle morphology J:89404
abnormal impulse conducting system morphology J:89404
abnormal myocardial fiber morphology J:89404
atrioventricular block J:89404
atrioventricular node hypoplasia J:89404
cardiac hypertrophy J:89404
cardiac interstitial fibrosis J:89404
normal cardiovascular system phenotype J:89404
dilated cardiomyopathy J:89404
hydrops fetalis J:89404
myocardial ventricular hypertrabeculation J:89404
perinatal lethality, incomplete penetrance J:89404
Myl2tm1(cre)Krc/Myl2+
Txnrd2tm1Marc/Txnrd2tm1.1Marc
involves: 129P2/OlaHsd * C57BL/6 		abnormal myocardial fiber morphology J:94136
congestive heart failure J:94136
dilated heart atrium J:94136
edema J:94136
globular heart J:94136
liver vascular congestion J:94136
neonatal lethality, complete penetrance J:94136
thin ventricular wall J:94136
Myl2tm1(cre)Krc/Myl2+
Srsf1tm1Xdfu/Srsf1tm1Xdfu
involves: 129S4/SvJae 		abnormal cardiac muscle contractility J:96039
abnormal myocardial fiber morphology J:96039
cardiac fibrosis J:96039
cardiac hypertrophy J:96039
decreased heart left ventricle posterior wall thickness J:96039
decreased heart rate J:96039
dilated cardiomyopathy J:96039
premature death J:96039
Myl2tm1(cre)Krc/Myl2+
Txnrd1tm1Marc/Txnrd1tm1.1Marc
involves: 129P2/OlaHsd * C57BL/6J 		normal cardiovascular system phenotype J:96818
Myl2tm1(cre)Krc/Myl2+
Ptk2tm1.1Guan/Ptk2tm1.1Guan
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal myocardial fiber morphology J:105371
abnormal myocardium layer morphology J:105371
cardiac hypertrophy J:105371
cardiac interstitial fibrosis J:105371
dilated heart left ventricle J:105371
disorganized myocardium J:105371
Myl2tm1(cre)Krc/Myl2+
Slc8a1tm1Kdp/Slc8a1tm1Kdp
involves: 129S4/SvJae 		abnormal myocardial fiber physiology J:101484
decreased cardiac muscle contractility J:101484
enlarged heart J:101484
pregnancy-related premature death J:101484
premature death J:101484
Myl2tm1(cre)Krc/Myl2+
Sp4tm2Krc/Sp4tm2Krc
involves: 129S4/SvJae 		abnormal heart morphology J:107057
Myl2tm1(cre)Krc/Myl2+
Vcltm1Ross/Vcltm1Ross
involves: 129S4/SvJae * Black Swiss * C57BL/6 * SJL 		abnormal cardiac muscle relaxation J:129075
abnormal cardiovascular system morphology J:129075
abnormal cardiovascular system physiology J:129075
abnormal impulse conducting system conduction J:129075
abnormal intercalated disk morphology J:129075
abnormal myocardial fiber morphology J:129075
cardiac fibrosis J:129075
cardiac hypertrophy J:129075
congestive heart failure J:129075
decreased cardiac muscle contractility J:129075
dilated cardiomyopathy J:129075
dilated heart left ventricle J:129075
heart block J:129075
increased heart weight J:129075
irregular heartbeat J:129075
premature death J:129075
ventricular tachycardia J:129075
Myl2tm1(cre)Krc/Myl2+
Pip5k1ctm2Csab/Pip5k1ctm2Csab
Not Specified 		abnormal platelet aggregation J:196476
abnormal platelet physiology J:196476
Pak1tm1.1Xwg/Pak1tm1.1Xwg
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 		cardiac fibrosis J:193804
cardiac hypertrophy J:193804
congestive heart failure J:193804
decreased cardiac muscle contractility J:193804
increased cardiomyocyte apoptosis J:193804
increased heart weight J:193804
increased myocardial fiber size J:193804
increased response of heart to induced stress J:193804
pulmonary edema J:193804
Tg(Myh6-GFP,MAP2K3)58Ywa/?
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiovascular system physiology J:72242
abnormal myocardial fiber morphology J:72242
cardiac interstitial fibrosis J:72242
increased heart atrium size J:72242
increased heart weight J:72242
premature death J:72242
pulmonary edema J:72242
respiratory distress J:72242
thin ventricular wall J:72242
Tg(Myh6-GFP,MAP2K6)8Ywa/?
Myl2tm1(cre)Krc/Myl2+
involves: 129S1/Sv * 129X1/SvJ 		abnormal cardiovascular system physiology J:72242
cardiac interstitial fibrosis J:72242
increased heart atrium size J:72242
increased heart weight J:72242
increased myocardial fiber size J:72242
premature death J:72242
pulmonary edema J:72242
respiratory distress J:72242
Vdrtm1.1Sgcg/Vdrtm1.2Sgcg
Myl2tm1(cre)Krc/Myl2+
involves: 129 * C57BL/6 * CBA * SJL 		abnormal heart ventricle morphology J:189471
cardiac hypertrophy J:189471
normal cardiovascular system phenotype J:189471
decreased mean systemic arterial blood pressure J:189471
decreased systemic arterial diastolic blood pressure J:189471
normal endocrine/exocrine gland phenotype J:189471
normal homeostasis/metabolism phenotype J:189471
increased circulating atrial natriuretic factor J:189471
increased heart left ventricle weight J:189471
increased myocardial fiber size J:189471
thick interventricular septum J:189471
thick ventricular wall J:189471
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11/19/2024
MGI 6.24 		The Jackson Laboratory