Ncf2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ncf2
neutrophil cytosolic factor 2
MGI:97284

34 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ncf2^{tm1a(EUCOMM)Wtsi}/Ncf2^{tm1a(EUCOMM)Wtsi} C57BL/6N-Ncf2^{tm1a(EUCOMM)Wtsi}/Wtsi	decreased alpha-beta T cell number	J:211773
	decreased circulating thyroxine level	J:211773
	decreased grip strength	J:211773
	decreased leukocyte cell number	J:211773
	decreased NK cell number	J:211773
	decreased NK T cell number	J:211773
	decreased regulatory T cell number	J:211773
	decreased T cell number	J:211773
	increased circulating iron level	J:211773
	increased KLRG1-positive NK cell number	J:211773
	increased mean platelet volume	J:211773
Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2⁺ NZM2328.B6(Cg)-Ncf2^{tm1b(EUCOMM)Wtsi}	abnormal redox activity	J:260777
	abnormal renal glomerulus morphology	J:260777
	abnormal spleen germinal center morphology	J:260777
	increased activated T cell number	J:260777
	increased anti-double stranded DNA antibody level	J:260777
	increased B cell number	J:260777
	increased CD4-positive, alpha-beta memory T cell number	J:260777
	increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	J:260777
	increased CD8-positive, alpha-beta T cell number	J:260777
	increased follicular B cell number	J:260777
	increased germinal center B cell number	J:260777
	increased susceptibility to systemic lupus erythematosus	J:260777
	increased T cell number	J:260777
	increased urine protein level	J:260777
	premature death	J:260777
Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2^{tm1b(EUCOMM)Wtsi} B6(Cg)-Ncf2^{tm1b(EUCOMM)Wtsi}	decreased CD8-positive, alpha-beta T cell number	J:260777
	increased susceptibility to fungal infection	J:260777
	lung inflammation	J:260777
Ncf2^{tm1b(EUCOMM)Wtsi}/Ncf2^{tm1b(EUCOMM)Wtsi} NZM2328.B6(Cg)-Ncf2^{tm1b(EUCOMM)Wtsi}	abnormal kidney interstitium morphology	J:260777
	abnormal mesangial matrix morphology	J:260777
	abnormal redox activity	J:260777
	abnormal renal glomerulus morphology	J:260777
	abnormal spleen germinal center morphology	J:260777
	glomerular crescent	J:260777
	increased activated T cell number	J:260777
	increased anti-double stranded DNA antibody level	J:260777
	increased B cell number	J:260777
	increased follicular B cell number	J:260777
	increased germinal center B cell number	J:260777
	increased susceptibility to systemic lupus erythematosus	J:260777
	increased T cell number	J:260777
	increased urine protein level	J:260777
	premature death	J:260777
	renal glomerular immunoglobulin deposits	J:260777
	renal glomerular protein deposits	J:260777

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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