Neb Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Neb
nebulin
MGI:97292

39 phenotypes from 7 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Neb^m1Anu/Neb^m2Anu C57BL/6J-Neb^m1Anu Neb^m2Anu	abnormal muscle fiber morphology	J:285564
	abnormal muscle physiology	J:285564
	abnormal skeletal muscle fiber type ratio	J:285564
	decreased body size	J:285564
	decreased grip strength	J:285564
	decreased locomotor activity	J:285564
	decreased skeletal muscle fiber diameter	J:285564
	decreased skeletal muscle fiber size	J:285564
	impaired skeletal muscle contractility	J:285564
	increased variability of skeletal muscle fiber size	J:285564
Neb^m2Anu/Neb⁺ C57BL/6J-Neb^m2Anu	decreased body weight	J:285564
Neb^m2Anu/Neb^m2Anu C57BL/6J-Neb^m2Anu	preweaning lethality, complete penetrance	J:285564
Neb^tm1(cre)Chen/Neb^tm1(cre)Chen involves: 129S1/Sv * 129X1/SvJ * Black Swiss	abnormal A band morphology	J:111470
	abnormal I band morphology	J:111470
	abnormal muscle fiber morphology	J:111470
	abnormal sarcomere morphology	J:111470
	abnormal suckling behavior	J:111470
	abnormal Z line morphology	J:111470
	decreased body weight	J:111470
	decreased total body fat amount	J:111470
	normal muscle phenotype	J:111470
	postnatal lethality, complete penetrance	J:111470
Neb^tm1.1Hgra/Neb^tm1.1Hgra involves: C57BL/6 * C57BL/6J * SJL	abnormal muscle physiology	J:206854
	abnormal sarcomere morphology	J:206854
	abnormal skeletal muscle fiber morphology	J:206854
	abnormal Z line morphology	J:206854
	decreased skeletal muscle fiber size	J:206854
	muscle weakness	J:206854
	postnatal growth retardation	J:206854
	postnatal lethality, complete penetrance	J:206854
Neb^tm1Slbt/Neb^tm1Slbt involves: 129P2/OlaHsd	abnormal gait	J:119578
	abnormal H zone morphology	J:119578
	abnormal muscle contractility	J:119578
	abnormal sarcomere morphology	J:119578
	blepharoptosis	J:119578
	kyphosis	J:119578
	lethality at weaning, complete penetrance	J:119578
	postnatal growth retardation	J:119578
	postnatal lethality, incomplete penetrance	J:119578
	progressive muscle weakness	J:119578
Neb^tm2.1Chen/Neb^tm2.1Chen involves: 129 * Black Swiss	abnormal muscle electrophysiology	J:211217
	increased susceptibility to injury	J:211217
	normal muscle phenotype	J:211217
Neb^tm2Hgra/Neb^tm2Hgra Tg(Ckmm-cre)5Khn/0 involves: 129S6/SvEvTac * FVB	abnormal A band morphology	J:225840
	abnormal H zone morphology	J:225840
	abnormal muscle fiber morphology	J:225840
	abnormal sarcomere morphology	J:225840
	abnormal skeletal muscle fiber size	J:225840
	abnormal skeletal muscle fiber type ratio	J:225840
	abnormal Z line morphology	J:225840
	decreased body weight	J:225840
	decreased quadriceps weight	J:225840
	decreased skeletal muscle weight	J:225840
	impaired exercise endurance	J:225840
	impaired skeletal muscle contractility	J:225840
	increased skeletal muscle fiber number	J:225840
	premature death	J:225840

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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