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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nedd4
neural precursor cell expressed, developmentally down-regulated 4
MGI:97297
84 phenotypes from 8 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nedd4Gt(OST16211)Lex/Nedd4+
involves: 129S5/SvEvBrd * C57BL/6J 		decreased body weight J:103485
Nedd4Gt(OST16211)Lex/Nedd4Gt(OST16211)Lex
involves: 129S5/SvEvBrd * C57BL/6J 		neonatal lethality J:103485
Nedd4Gt(XA209)Byg/Nedd4+
involves: 129P2/OlaHsd 		decreased birth weight J:207675
decreased fetal weight J:207675
postnatal growth retardation J:207675
Nedd4Gt(XA209)Byg/Nedd4Gt(XA209)Byg
B6.129P2-Nedd4Gt(XA209)Byg 		abnormal meiosis J:320185
abnormal Sertoli cell development J:320185
abnormal sex determination J:320185
abnormal testis development J:320185
fetal growth retardation J:320185
lethality throughout fetal growth and development, complete penetrance J:320185
primary sex reversal J:320185
sex reversal J:320185
small gonad J:320185
Nedd4Gt(XA209)Byg/Nedd4Gt(XA209)Byg
involves: 129P2/OlaHsd 		abnormal cranial ganglia morphology J:203994
abnormal craniofacial bone morphology J:203994
abnormal craniofacial morphology J:203994
abnormal frontal bone morphology J:203994
abnormal glossopharyngeal ganglion morphology J:203994
abnormal mandible morphology J:203994
abnormal maxilla morphology J:203994
abnormal neural crest cell physiology J:203994
abnormal premaxilla morphology J:203994
abnormal T cell activation J:143560
abnormal temporal bone tympanic part morphology J:203994
abnormal tongue position J:203994
abnormal vagus ganglion morphology J:203994
absent palate bones J:203994
centrally nucleated skeletal muscle fibers J:207675
cleft palate J:203994
decreased B cell number J:143560
decreased birth weight J:207675
decreased bone mass J:203994
decreased bone mineral density J:203994
decreased bone ossification J:203994
decreased cranial neural crest cell number J:203994
decreased embryo size J:203994, J:207675
decreased fetal size J:207675
decreased fetal weight J:207675
decreased fibroblast proliferation J:207675
decreased IgG1 level J:143560
decreased IgG2b level J:143560
decreased IgG3 level J:143560
decreased interleukin-2 secretion J:143560
decreased T cell proliferation J:143560
delayed muscle development J:207675
increased CD4-positive, alpha-beta T cell number J:143560
increased CD8-positive, alpha-beta T cell number J:143560
increased cranial neural crest cell apoptosis J:203994
increased embryonic neuroepithelium apoptosis J:203994
increased IgM level J:143560
increased T cell number J:143560
increased variability of skeletal muscle fiber size J:207675
palatal shelves fail to meet at midline J:203994
perinatal lethality, complete penetrance J:143560, J:207675
preweaning lethality, complete penetrance J:207675
prominent forehead J:203994
small basioccipital bone J:203994
small exoccipital bone J:203994
small mandible J:203994
small maxilla J:203994
small trigeminal ganglion J:203994
small vertebrae J:203994
underdeveloped hair follicles J:207675
Nedd4Gt(XB398)Byg/Nedd4Gt(XB398)Byg
involves: 129P2/OlaHsd 		decreased B cell number J:143560
decreased IgG1 level J:143560
decreased IgG2b level J:143560
decreased IgG3 level J:143560
decreased interleukin-2 secretion J:143560
decreased T cell proliferation J:143560
increased CD4-positive, alpha-beta T cell number J:143560
increased CD8-positive, alpha-beta T cell number J:143560
increased IgM level J:143560
increased T cell number J:143560
perinatal lethality, complete penetrance J:143560
preweaning lethality, complete penetrance J:207675
Nedd4Gt(XB786)Byg/Nedd4Gt(XB786)Byg
involves: 129P2/OlaHsd 		prenatal lethality, complete penetrance J:137202
Nedd4tm1Bros/Nedd4tm1Bros
Not Specified 		prenatal lethality, complete penetrance J:137202
Nedd4tm2b(EUCOMM)Hmgu/Nedd4+
C57BL/6N-Nedd4tm2b(EUCOMM)Hmgu/H 		abnormal behavior J:211773
abnormal gait J:211773
decreased circulating creatinine level J:211773
decreased locomotor activity J:211773
decreased thigmotaxis J:211773
impaired glucose tolerance J:211773
increased grip strength J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
tremors J:211773
Nedd4tm2b(EUCOMM)Hmgu/Nedd4tm2b(EUCOMM)Hmgu
C57BL/6N-Nedd4tm2b(EUCOMM)Hmgu/H 		preweaning lethality, complete penetrance J:211773
Nedd4tm2Bros/Nedd4tm2Bros
involves: C57BL/6N 		abnormal dendrite morphology J:164745
abnormal miniature excitatory postsynaptic currents J:164745
abnormal neuron morphology J:164745
abnormal synapse morphology J:164745
abnormal synaptic vesicle number J:164745
decreased excitatory postsynaptic current amplitude J:164745
fetal growth retardation J:164745
hemorrhage J:164745
lethality throughout fetal growth and development, incomplete penetrance J:164745
normal nervous system phenotype J:164745
perinatal lethality, complete penetrance J:164745
Nedd4tm3.1Bros/Nedd4tm3.1Bros
Neurod6tm1(cre)Kan/Neurod6+
involves: 129 * C57BL/6 * C57BL/6N * SJL 		abnormal cerebral hemisphere morphology J:164745
abnormal dendrite morphology J:164745
normal nervous system phenotype J:164745
thin cerebral cortex J:164745
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory