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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nf2
neurofibromin 2
MGI:97307
38 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cdkn2atm1.1Brn/Cdkn2a+
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		increased mesothelioma incidence J:132943
increased metastatic potential J:132943
increased rhabdomyosarcoma incidence J:132943
increased tumor incidence J:132943
pleural effusion J:132943
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
involves: 129P2/OlaHsd * FVB/N 		abnormal meninges morphology J:131179
hydrocephaly J:131179
increased liver tumor incidence J:131179
increased meningioma incidence J:131179
increased osteoma incidence J:131179
osseous metaplasia J:131179
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+
involves: 129P2/OlaHsd * FVB/N 		increased meningioma incidence J:173718
normal mortality/aging J:173718
normal neoplasm J:173718
Cdkn2atm1.1Brn/Cdkn2atm1.1Brn
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		increased mesothelioma incidence J:132943
increased rhabdomyosarcoma incidence J:132943
increased Schwannoma incidence J:132943
increased tumor incidence J:132943
premature death J:132943
Cdkn2atm2Brn/Cdkn2a+
Nf2tm2Gth/Nf2tm2Gth
involves: 129P2/OlaHsd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
Cdkn2atm2Brn/Cdkn2atm2Brn
Nf2tm2Gth/Nf2+
involves: 129P2/OlaHsd 		increased leukemia incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
Cdkn2atm2Brn/Cdkn2atm2Brn
Nf2tm2Gth/Nf2tm2Gth
involves: 129P2/OlaHsd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased rhabdomyosarcoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
Hrastm1Jaf/Hrastm1Jaf
Nf2tm2Gth/Nf2tm2Gth
Tg(TPO-cre)1Shk/0
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr 		increased thyroid tumor incidence J:231492
Nf2tm2Gth/Nf2+
Trp53tm1Brd/Trp53+
Tg(Mpz-cre)3Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		increased neurofibrosarcoma incidence J:92413
increased osteoma incidence J:92413
increased osteosarcoma incidence J:92413
increased skeletal tumor incidence J:92413
premature death J:92413
Nf2tm2Gth/Nf2+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		increased leukemia incidence J:132943
increased mesothelioma incidence J:132943
increased Schwannoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
Nf2tm2Gth/Nf2tm2Gth
Ptgdstm1.1(cre)Gvn/Ptgds+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * FVB/N 		increased nervous system tumor incidence J:173718
increased osteosarcoma incidence J:173718
premature death J:173718
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brd/Trp53+
Tg(Mpz-cre)2Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		abnormal osteoblast morphology J:92413
abnormal renal tubule morphology J:92413
abnormal Schwann cell morphology J:92413
abnormal tooth development J:92413
cataract J:92413
decreased survivor rate J:92413
increased leiomyosarcoma incidence J:92413
increased nervous system tumor incidence J:92413
increased neurofibroma incidence J:92413
increased neurofibrosarcoma incidence J:92413
increased sarcoma incidence J:92413
increased Schwannoma incidence J:92413
osseous metaplasia J:92413
premature death J:92413
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brd/Trp53+
Tg(Mpz-cre)3Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		decreased survivor rate J:92413
increased neurofibrosarcoma incidence J:92413
premature death J:92413
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brd/Trp53tm1Brd
Tg(Mpz-cre)2Brn/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		abnormal osteoblast morphology J:92413
abnormal renal tubule morphology J:92413
abnormal Schwann cell morphology J:92413
cataract J:92413
increased extremity angiosarcoma incidence J:92413
increased neurofibrosarcoma incidence J:92413
increased osteoma incidence J:92413
increased osteosarcoma incidence J:92413
increased rhabdomyosarcoma incidence J:92413
increased sarcoma incidence J:92413
increased tumor incidence J:92413
osseous metaplasia J:92413
premature death J:92413
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53+
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased mesothelioma incidence J:132943
increased Schwannoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
Nf2tm2Gth/Nf2tm2Gth
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S7/SvEvBrd 		enlarged liver J:132943
increased leukemia incidence J:132943
increased mesothelioma incidence J:132943
increased rhabdomyosarcoma incidence J:132943
increased Schwannoma incidence J:132943
increased T cell derived lymphoma incidence J:132943
increased tumor incidence J:132943
increased uterus leiomyoma incidence J:132943
premature death J:132943
Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1+
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		enlarged liver J:162628
normal liver/biliary system phenotype J:162628
normal neoplasm J:162628
Nf2tm2Gth/Nf2tm2Gth
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		normal liver/biliary system phenotype J:162628
normal neoplasm J:162628
Nf2tm2Gth/Nf2tm2Gth
Yap1tm2.1Dupa/Yap1tm2.1Dupa
involves: 129P2/OlaHsd 		abnormal bile duct epithelium morphology J:223215
abnormal bile duct physiology J:223215
enlarged liver J:223215
increased hamartoma incidence J:223215
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory