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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfix
nuclear factor I/X
MGI:97311
60 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfixtm1.1Rmg/Nfix+
involves: 129S4/SvJae * C57BL/6J 		abnormal anterior commissure morphology J:295051
abnormal brain commissure morphology J:295051
abnormal cortical plate morphology J:295051
abnormal hippocampal commissure morphology J:295051
abnormal long-term spatial reference memory J:295051
abnormal neocortex morphology J:295051
abnormal response to social novelty J:295051
abnormal retrosplenial region morphology J:295051
abnormal short-term spatial reference memory J:295051
abnormal social investigation J:295051
abnormal somatosensory cortex morphology J:295051
impaired active avoidance behavior J:295051
impaired spatial learning J:295051
increased brain size J:295051
increased cingulate cortex size J:295051
increased neocortex size J:295051
Nfixtm1.1Rmg/Nfixtm1.1Rmg
involves: 129S4/SvJae * C57BL/6 * C57BL/6J 		abnormal brain morphology J:137651
abnormal cerebral cortex morphology J:137651
abnormal corpus callosum morphology J:137651
abnormal dentate gyrus morphology J:137651
abnormal hippocampus CA1 region morphology J:137651
abnormal hippocampus morphology J:137651
abnormal inner ear canal morphology J:137651
normal craniofacial phenotype J:137651
delayed eyelid opening J:137651
enlarged lateral ventricles J:137651
increased brain weight J:137651
slow postnatal weight gain J:137651
weight loss J:137651
Nfixtm1Aes/Nfix+
involves: 129S1/Sv * C57BL/6 		abnormal corpus callosum morphology J:122250
decreased body size J:122250
Nfixtm1Aes/Nfixtm1Aes
involves: 129S1/Sv * C57BL/6 		abnormal bone mineralization J:122250
abnormal corpus callosum morphology J:122250
abnormal cranial suture morphology J:122250
abnormal craniofacial bone morphology J:122250
abnormal intervertebral disk morphology J:122250
abnormal long bone epiphyseal plate morphology J:122250
abnormal long bone epiphyseal plate proliferative zone J:122250
abnormal long bone hypertrophic chondrocyte zone J:122250
abnormal small intestine morphology J:122250
abnormal spine curvature J:122250
abnormal timing of postnatal eyelid opening J:122250
abnormal vertebral body morphology J:122250
ataxia J:122250
decreased body size J:122250
decreased compact bone thickness J:122250
decreased trabecular bone mass J:122250
decreased trabecular bone thickness J:122250
delayed bone ossification J:122250
delayed endochondral bone ossification J:122250
dilated lateral ventricle J:122250
dilated third ventricle J:122250
domed cranium J:122250
hydrocephaly J:122250
increased long bone epiphyseal plate size J:122250
intervertebral disk degeneration J:122250
kyphosis J:122250
lethality at weaning, incomplete penetrance J:122250
limb grasping J:122250
lordosis J:122250
megacephaly J:122250
scoliosis J:122250
weight loss J:122250
Nfixtm1Rmg/Nfixtm1Rmg
involves: 129S4/SvJae * C57BL/6 		no abnormal phenotype detected J:137651
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory