About   Help   FAQ
Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI:97312
101 phenotypes from 11 alleles in 18 genetic backgrounds
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
Nfkb1Gt(pT1ATGBetageo)1Ruiz/Nfkb1Gt(pT1ATGBetageo)1Ruiz
involves: 129S2/SvPas * C57BL/6 		no abnormal phenotype detected J:85162
Nfkb1M1Btlr/Nfkb1+
C57BL/6J-Nfkb1M1Btlr 		decreased IgG level J:216054
impaired humoral immune response J:216054
Nfkb1M1Btlr/Nfkb1M1Btlr
C57BL/6J-Nfkb1M1Btlr 		decreased IgG level J:216054
impaired humoral immune response J:216054
Nfkb1m2Btlr/Nfkb1+
C57BL/6J-Nfkb1m2Btlr 		abnormal humoral immune response J:254822
decreased central memory CD4-positive, alpha-beta T cell number J:254822
decreased effector memory CD4-positive, alpha-beta T cell number J:254822
decreased IgM level J:254822
Nfkb1m2Btlr/Nfkb1m2Btlr
C57BL/6J-Nfkb1m2Btlr 		abnormal humoral immune response J:254822
decreased CD8-positive, naive alpha-beta T cell number J:254822
decreased central memory CD4-positive, alpha-beta T cell number J:254822
decreased effector memory CD4-positive, alpha-beta T cell number J:254822
decreased IgE level J:254822
decreased IgG level J:254822
decreased IgM level J:254822
increased central memory CD8 positive, alpha-beta T cell number J:254822
Nfkb1M3Btlr/Nfkb1+
C57BL/6J-Nfkb1M3Btlr 		abnormal humoral immune response J:254821
decreased IgE level J:254821
decreased IgG level J:254821
increased central memory CD8 positive, alpha-beta T cell number J:254821
Nfkb1M3Btlr/Nfkb1M3Btlr
C57BL/6J-Nfkb1M3Btlr 		abnormal humoral immune response J:254821
decreased IgE level J:254821
decreased IgG level J:254821
increased central memory CD8 positive, alpha-beta T cell number J:254821
increased susceptibility to induced colitis J:254821
Nfkb1M4Btlr/Nfkb1M4Btlr
C57BL/6J-Nfkb1M4Btlr 		decreased B-1 B cell number J:265169
Nfkb1M5Btlr/Nfkb1M5Btlr
C57BL/6J-Nfkb1M5Btlr 		decreased B-1a cell number J:272117
decreased IgE level J:272117
decreased interleukin-1 beta secretion J:272117
Nfkb1M6Btlr/Nfkb1M6Btlr
C57BL/6J-Nfkb1M6Btlr 		decreased IgE level J:272148
Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
B6JTyr;B6N-Nfkb1tm1a(KOMP)Wtsi/Wtsi 		abnormal cornea morphology J:165965
abnormal skin condition J:165965
decreased circulating amylase level J:175295
decreased circulating sodium level J:165965
decreased lean body mass J:175295
decreased mean corpuscular hemoglobin concentration J:175295
decreased thermal nociceptive threshold J:165965
increased circulating alkaline phosphatase level J:165965
increased circulating free fatty acids level J:175295
increased leukocyte cell number J:165965, J:175295
increased thermal nociceptive threshold J:165965
Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
involves: C57BL/6 * C57BL/6N 		decreased IgA level J:213427
decreased IgG1 level J:213427
decreased NK cell number J:213427
decreased regulatory T cell number J:213427
decreased respiratory quotient J:213427
increased circulating alkaline phosphatase level J:213427
increased leukocyte cell number J:213427
increased susceptibility to bacterial infection J:213427
lymphoid hyperplasia J:213427
Nfkb1tm1Bal/Nfkb1tm1Bal
B6.Cg-Nfkb1tm1Bal/J 		abnormal B cell physiology J:113556
Nfkb1tm1Bal/Nfkb1tm1Bal
B6;129P-Nfkb1tm1Bal/J 		abnormal calcium ion homeostasis J:107245
abnormal CD4-positive, alpha-beta T cell physiology J:118907
abnormal cochlear inner hair cell morphology J:107245
abnormal cytokine secretion J:79107
abnormal dendritic cell physiology J:118907
abnormal macrophage physiology J:118907
abnormal professional antigen presenting cell physiology J:118907
cochlear ganglion degeneration J:107245
decreased cochlear nerve compound action potential J:107245
decreased susceptibility to autoimmune diabetes J:118907
normal homeostasis/metabolism phenotype J:91366
normal immune system phenotype J:118907
increased apoptosis J:118907
increased susceptibility to age-related hearing loss J:107245
increased susceptibility to noise-induced hearing loss J:107245
normal muscle phenotype J:135692
Nfkb1tm1Bal/Nfkb1tm1Bal
involves: 129P2/OlaHsd 		decreased marginal zone B cell number J:65246
normal immune system phenotype J:113514
Nfkb1tm1Bal/Nfkb1tm1Bal
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:30268
abnormal colon morphology J:67107
abnormal humoral immune response J:37184
abnormal Peyer's patch follicle morphology J:77049
abnormal Peyer's patch germinal center morphology J:77049
abnormal Peyer's patch T cell area morphology J:77049
cecum inflammation J:67107
decreased B cell proliferation J:30268, J:37184
decreased IgA level J:37184
decreased IgE level J:37184
decreased IgG1 level J:37184
decreased IgM level J:30268
decreased immunoglobulin level J:37184
decreased interleukin-6 secretion J:37184
decreased myeloid dendritic cell number J:77049
decreased Peyer's patch number J:77049
decreased susceptibility to Picornaviridae infection induced morbidity/mortality J:37184
diarrhea J:67107
increased susceptibility to bacterial infection J:37184, J:67107
increased susceptibility to bacterial infection induced morbidity/mortality J:37184
large intestinal inflammation J:67107
peritoneal inflammation J:67107
premature death J:37184
small Peyer's patches J:77049
Nfkb1tm1Brv/Nfkb1tm1Brv
involves: 129S1/Sv 		abnormal bone marrow cell morphology/development J:46912
abnormal cytokine secretion J:46912
abnormal humoral immune response J:46912
abnormal inflammatory response J:46912
abnormal lymph organ size J:46912
abnormal lymphocyte physiology J:46912
decreased erythrocyte cell number J:46912
decreased IgG3 level J:46912
decreased interleukin-2 secretion J:46912
decreased interleukin-4 secretion J:46912
decreased single-positive T cell number J:46912
decreased T cell proliferation J:46912
decreased tumor necrosis factor secretion J:46912
enlarged lymph nodes J:46912
enlarged spleen J:46912
extramedullary hematopoiesis J:46912
increased B cell proliferation J:46912
increased IgE level J:46912
increased IgG1 level J:46912
increased immunoglobulin level J:46912
increased susceptibility to bacterial infection J:46912
lethargy J:46912
liver inflammation J:46912
lung inflammation J:46912
myeloid hyperplasia J:46912
postnatal growth retardation J:46912
premature death J:46912
preweaning lethality, incomplete penetrance J:46912
rough coat J:46912
Nfkb1tm1Brv/Nfkb1tm1Brv
involves: 129S1/Sv * C57BL/6 		decreased osteoclast cell number J:44112
normal skeleton phenotype J:44112
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S4/SvJae 		decreased tumor necrosis factor secretion J:196528
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S4/SvJae * 129S8/SvEv 		abnormal inguinal lymph node morphology J:142340
absent inguinal lymph nodes J:142340
decreased circulating interleukin-2 level J:142340
decreased memory T cell number J:142340
decreased regulatory T cell number J:142340
decreased T cell proliferation J:142340
small inguinal lymph nodes J:142340
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 		decreased memory T cell number J:142340
decreased NK T cell number J:142340
decreased regulatory T cell number J:142340
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory