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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nfkb1
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
MGI:97312
101 phenotypes from 11 alleles in 18 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Nfkb1Gt(pT1ATGBetageo)1Ruiz/Nfkb1Gt(pT1ATGBetageo)1Ruiz
involves: 129S2/SvPas * C57BL/6 		no abnormal phenotype detected J:85162
Nfkb1M1Btlr/Nfkb1+
C57BL/6J-Nfkb1M1Btlr 		decreased IgG level J:216054
impaired humoral immune response J:216054
Nfkb1M1Btlr/Nfkb1M1Btlr
C57BL/6J-Nfkb1M1Btlr 		decreased IgG level J:216054
impaired humoral immune response J:216054
Nfkb1m2Btlr/Nfkb1+
C57BL/6J-Nfkb1m2Btlr 		abnormal humoral immune response J:254822
decreased central memory CD4-positive, alpha-beta T cell number J:254822
decreased effector memory CD4-positive, alpha-beta T cell number J:254822
decreased IgM level J:254822
Nfkb1m2Btlr/Nfkb1m2Btlr
C57BL/6J-Nfkb1m2Btlr 		abnormal humoral immune response J:254822
decreased CD8-positive, naive alpha-beta T cell number J:254822
decreased central memory CD4-positive, alpha-beta T cell number J:254822
decreased effector memory CD4-positive, alpha-beta T cell number J:254822
decreased IgE level J:254822
decreased IgG level J:254822
decreased IgM level J:254822
increased central memory CD8 positive, alpha-beta T cell number J:254822
Nfkb1M3Btlr/Nfkb1+
C57BL/6J-Nfkb1M3Btlr 		abnormal humoral immune response J:254821
decreased IgE level J:254821
decreased IgG level J:254821
increased central memory CD8 positive, alpha-beta T cell number J:254821
Nfkb1M3Btlr/Nfkb1M3Btlr
C57BL/6J-Nfkb1M3Btlr 		abnormal humoral immune response J:254821
decreased IgE level J:254821
decreased IgG level J:254821
increased central memory CD8 positive, alpha-beta T cell number J:254821
increased susceptibility to induced colitis J:254821
Nfkb1M4Btlr/Nfkb1M4Btlr
C57BL/6J-Nfkb1M4Btlr 		decreased B-1 B cell number J:265169
Nfkb1M5Btlr/Nfkb1M5Btlr
C57BL/6J-Nfkb1M5Btlr 		decreased B-1a cell number J:272117
decreased IgE level J:272117
decreased interleukin-1 beta secretion J:272117
Nfkb1M6Btlr/Nfkb1M6Btlr
C57BL/6J-Nfkb1M6Btlr 		decreased IgE level J:272148
Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
B6JTyr;B6N-Nfkb1tm1a(KOMP)Wtsi/Wtsi 		abnormal cornea morphology J:165965
abnormal skin condition J:165965
decreased circulating amylase level J:175295
decreased circulating sodium level J:165965
decreased lean body mass J:175295
decreased mean corpuscular hemoglobin concentration J:175295
decreased thermal nociceptive threshold J:165965
increased circulating alkaline phosphatase level J:165965
increased circulating free fatty acids level J:175295
increased leukocyte cell number J:165965, J:175295
increased thermal nociceptive threshold J:165965
Nfkb1tm1a(KOMP)Wtsi/Nfkb1tm1a(KOMP)Wtsi
involves: C57BL/6 * C57BL/6N 		decreased IgA level J:213427
decreased IgG1 level J:213427
decreased NK cell number J:213427
decreased regulatory T cell number J:213427
decreased respiratory quotient J:213427
increased circulating alkaline phosphatase level J:213427
increased leukocyte cell number J:213427
increased susceptibility to bacterial infection J:213427
lymphoid hyperplasia J:213427
Nfkb1tm1Bal/Nfkb1tm1Bal
B6.Cg-Nfkb1tm1Bal/J 		abnormal B cell physiology J:113556
Nfkb1tm1Bal/Nfkb1tm1Bal
B6;129P-Nfkb1tm1Bal/J 		abnormal calcium ion homeostasis J:107245
abnormal CD4-positive, alpha-beta T cell physiology J:118907
abnormal cochlear inner hair cell morphology J:107245
abnormal cytokine secretion J:79107
abnormal dendritic cell physiology J:118907
abnormal macrophage physiology J:118907
abnormal professional antigen presenting cell physiology J:118907
cochlear ganglion degeneration J:107245
decreased cochlear nerve compound action potential J:107245
decreased susceptibility to autoimmune diabetes J:118907
normal homeostasis/metabolism phenotype J:91366
normal immune system phenotype J:118907
increased apoptosis J:118907
increased susceptibility to age-related hearing loss J:107245
increased susceptibility to noise-induced hearing loss J:107245
normal muscle phenotype J:135692
Nfkb1tm1Bal/Nfkb1tm1Bal
involves: 129P2/OlaHsd 		decreased marginal zone B cell number J:65246
normal immune system phenotype J:113514
Nfkb1tm1Bal/Nfkb1tm1Bal
involves: 129P2/OlaHsd * C57BL/6 		abnormal class switch recombination J:30268
abnormal colon morphology J:67107
abnormal humoral immune response J:37184
abnormal Peyer's patch follicle morphology J:77049
abnormal Peyer's patch germinal center morphology J:77049
abnormal Peyer's patch T cell area morphology J:77049
cecum inflammation J:67107
decreased B cell proliferation J:30268, J:37184
decreased IgA level J:37184
decreased IgE level J:37184
decreased IgG1 level J:37184
decreased IgM level J:30268
decreased immunoglobulin level J:37184
decreased interleukin-6 secretion J:37184
decreased myeloid dendritic cell number J:77049
decreased Peyer's patch number J:77049
decreased susceptibility to Picornaviridae infection induced morbidity/mortality J:37184
diarrhea J:67107
increased susceptibility to bacterial infection J:37184, J:67107
increased susceptibility to bacterial infection induced morbidity/mortality J:37184
large intestinal inflammation J:67107
peritoneal inflammation J:67107
premature death J:37184
small Peyer's patches J:77049
Nfkb1tm1Brv/Nfkb1tm1Brv
involves: 129S1/Sv 		abnormal bone marrow cell morphology/development J:46912
abnormal cytokine secretion J:46912
abnormal humoral immune response J:46912
abnormal inflammatory response J:46912
abnormal lymph organ size J:46912
abnormal lymphocyte physiology J:46912
decreased erythrocyte cell number J:46912
decreased IgG3 level J:46912
decreased interleukin-2 secretion J:46912
decreased interleukin-4 secretion J:46912
decreased single-positive T cell number J:46912
decreased T cell proliferation J:46912
decreased tumor necrosis factor secretion J:46912
enlarged lymph nodes J:46912
enlarged spleen J:46912
extramedullary hematopoiesis J:46912
increased B cell proliferation J:46912
increased IgE level J:46912
increased IgG1 level J:46912
increased immunoglobulin level J:46912
increased susceptibility to bacterial infection J:46912
lethargy J:46912
liver inflammation J:46912
lung inflammation J:46912
myeloid hyperplasia J:46912
postnatal growth retardation J:46912
premature death J:46912
preweaning lethality, incomplete penetrance J:46912
rough coat J:46912
Nfkb1tm1Brv/Nfkb1tm1Brv
involves: 129S1/Sv * C57BL/6 		decreased osteoclast cell number J:44112
normal skeleton phenotype J:44112
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S4/SvJae 		decreased tumor necrosis factor secretion J:196528
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S4/SvJae * 129S8/SvEv 		abnormal inguinal lymph node morphology J:142340
absent inguinal lymph nodes J:142340
decreased circulating interleukin-2 level J:142340
decreased memory T cell number J:142340
decreased regulatory T cell number J:142340
decreased T cell proliferation J:142340
small inguinal lymph nodes J:142340
Nfkb1tm1Sley/Nfkb1tm1Sley
involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 		decreased memory T cell number J:142340
decreased NK T cell number J:142340
decreased regulatory T cell number J:142340
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory