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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Nhlh2
nescient helix loop helix 2
MGI:97324
81 phenotypes from 5 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Kiss1tm1.1(cre)Uboe/Kiss1+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J 		normal adipose tissue phenotype J:199640
normal growth/size/body region phenotype J:199640
normal reproductive system phenotype J:199640
Nhlh2em1(IMPC)Mbp/Nhlh2em1(IMPC)Mbp
C57BL/6N-Nhlh2em1(IMPC)Mbp/Ucd 		abnormal urinary bladder morphology J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased lean body mass J:211773
decreased locomotor activity J:211773
female infertility J:211773
impaired glucose tolerance J:211773
male infertility J:211773
Nhlh2tm1b(KOMP)Mbp/Nhlh2tm1b(KOMP)Mbp
C57BL/6N-Nhlh2tm1b(KOMP)Mbp/Tcp 		abnormal bone structure J:211773
abnormal cholesterol homeostasis J:211773
abnormal epididymis morphology J:211773
abnormal ovary morphology J:211773
abnormal seminal vesicle morphology J:211773
abnormal testis morphology J:211773
abnormal uterus morphology J:211773
absent epididymis J:211773
absent ovary J:211773
absent seminal vesicle J:211773
absent testes J:211773
decreased bone mineral content J:211773
decreased bone mineral density J:211773
decreased kidney weight J:211773
decreased lean body mass J:211773
decreased mean corpuscular hemoglobin concentration J:211773
eye hemorrhage J:211773
female infertility J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
increased mean corpuscular volume J:211773
increased spleen weight J:211773
increased total body fat amount J:211773
male infertility J:211773
preweaning lethality, incomplete penetrance J:211773
small uterus J:211773
Nhlh2tm1Irk/Nhlh2+
involves: 129S4/SvJae * C57BL/6 		abnormal motor capabilities/coordination/movement J:96351
increased percent body fat/body weight J:96351
increased susceptibility to age related obesity J:96351
polyphagia J:96351
Nhlh2tm1Irk/Nhlh2tm1Irk
involves: 129S4/SvJae * C57BL/6 		abnormal anogenital distance J:39356
abnormal estrous cycle J:101925
abnormal mating receptivity J:101925
abnormal seminal vesicle morphology J:39356
abnormal spermatogenesis J:39356
abnormal vas deferens morphology J:39356
abnormal voluntary movement J:96351
absent corpus luteum J:39356
azoospermia J:39356
bilateral cryptorchism J:39356
decreased circulating follicle stimulating hormone level J:39356
decreased circulating testosterone level J:39356
decreased core body temperature J:96351
decreased Leydig cell number J:39356
decreased litter size J:39356
decreased male germ cell number J:39356
decreased superovulation rate J:101925
delayed vaginal opening J:101925
early reproductive senescence J:101925
normal endocrine/exocrine gland phenotype J:39356
normal homeostasis/metabolism phenotype J:39356
impaired ovarian folliculogenesis J:39356
increased percent body fat/body weight J:96351
increased susceptibility to age related obesity J:96351
male infertility J:39356
obese J:39356
polyphagia J:96351
prolonged diestrus J:101925
prolonged proestrus J:101925
reduced female fertility J:39356, J:101925
reduced male mating frequency J:39356
seminiferous tubule degeneration J:39356
short estrus J:101925
small epididymis J:39356
small gonad J:39356
small male preputial gland J:39356
small ovary J:39356
small penis J:39356
small seminiferous tubules J:39356
small testis J:39356
small uterus J:39356
Nhlh2tm1Thbr/Nhlh2tm1Thbr
involves: 129S4/SvJae 		abnormal neuron morphology J:93303
increased susceptibility to age related obesity J:93303
small ovary J:93303
small penis J:93303
small testis J:93303
small uterus J:93303
Nhlh2tm1Thbr/Nhlh2tm1Thbr
Tg(Pomc-EGFP)1Low/0
involves: 129S4/SvJae * C57BL/6J 		decreased neuron number J:199640
ectopic neuron J:199640
increased neuron number J:199640
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Agrp-cre)1Gsb/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		normal adipose tissue phenotype J:199640
normal growth/size/body region phenotype J:199640
normal reproductive system phenotype J:199640
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(CMV-cre)1Cgn/0
involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 		decreased circulating estradiol level J:199640
decreased neuron number J:199640
decreased uterus weight J:199640
increased abdominal adipose tissue amount J:199640
increased body weight J:199640
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Tg(Pomc-EGFP)1Low/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * CBA 		decreased neuron number J:199640
normal homeostasis/metabolism phenotype J:199640
increased white adipose tissue amount J:199640
normal reproductive system phenotype J:199640
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Pomc-EGFP)1Low/0
Tg(Pomc1-cre)16Lowl/0
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * FVB/N 		normal adipose tissue phenotype J:199640
normal growth/size/body region phenotype J:199640
normal nervous system phenotype J:199640
normal reproductive system phenotype J:199640
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory