Nkx2-2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nkx2-2
NK2 homeobox 2
MGI:97347

33 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr involves: 129X1/SvJ	abnormal neuron specification	J:54240
	abnormal oligodendrocyte morphology	J:97013
	abnormal pancreatic beta cell differentiation	J:48576
	abnormal pancreatic islet morphology	J:48576
	abnormal serotonergic neuron morphology	J:54240
	absent oligodendrocytes	J:97013
	absent pancreatic beta cells	J:48576
	decreased glucagon secretion	J:48576
	decreased insulin secretion	J:48576
	decreased pancreatic alpha cell number	J:48576
	decreased PP cell number	J:48576
	hyperglycemia	J:48576
	increased motor neuron number	J:54240
	postnatal growth retardation	J:48576
	postnatal lethality, complete penetrance	J:48576, J:97013
Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * C57BL/6J * SJL	decreased pancreatic beta cell number	J:177838
	disorganized pancreatic islets	J:177838
	hyperglycemia	J:177838
	increased pancreatic alpha cell number	J:177838
	increased pancreatic epsilon cell number	J:177838
	premature death	J:177838
	reduced female fertility	J:177838
	reduced male fertility	J:177838
	small pancreatic islets	J:177838
Nkx2-2^tm3Suss/Nkx2-2^tm3Suss involves: 129S6/SvEvTac	abnormal nervous system morphology	J:178173
	abnormal pancreas morphology	J:178173
	abnormal pancreas physiology	J:178173
	postnatal growth retardation	J:178173
	postnatal lethality	J:178173
Nkx2-2^{tm4.1(cre/EGFP)Suss}/Nkx2-2⁺ involves: 129S6/SvEvTac * C57BL/6J	no abnormal phenotype detected	J:204532
Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss involves: 129S6/SvEvTac * C57BL/6J	normal endocrine/exocrine gland phenotype	J:204869
	normal growth/size/body region phenotype	J:204869
	normal homeostasis/metabolism phenotype	J:204869
	normal reproductive system phenotype	J:204869
Nkx2-2^tm5.1Suss/Nkx2-2^tm5.1Suss Tg(Pdx1-cre)6Tuv/0 involves: 129S6/SvEvTac * C57BL/6 * FVB/N * NTac:NIHBS * SJL	decreased pancreatic alpha cell number	J:204869
	decreased pancreatic beta cell number	J:204869
	hyperglycemia	J:204869
	increased circulating glucose level	J:204869
	increased pancreatic epsilon cell number	J:204869
	postnatal lethality, complete penetrance	J:204869

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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