Nkx2-2 Phenotype Annotations - Multigenic Genotypes

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nkx2-2
NK2 homeobox 2
MGI:97347

9 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Arx^tm1Gldn/Arx^tm1Gldn Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0 involves: 129 * Black Swiss * C57BL/6 * CBA/J * SJL	decreased pancreatic beta cell number	J:177838
	normal endocrine/exocrine gland phenotype	J:177838
	hyperglycemia	J:177838
Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0 involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL	abnormal pancreatic beta cell differentiation	J:177838
Dnmt3a^tm1Jae/Dnmt3a^tm1Jae Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Tg(Ins2-cre)23Herr/0 involves: Black Swiss * C57BL/6 * CBA/J * SJL	decreased pancreatic beta cell number	J:177838
	increased pancreatic alpha cell number	J:177838
En1^tm2(cre)Wrst/? Gt(ROSA)26Sor^{tm5(CAG-EGFP,-lacZ)Dym}/? Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr Tg(Fev-flpe)1Dym/? involves: 129S1/Sv * 129X1/SvJ	abnormal rhombomere morphology	J:136096
Nkx2-2^tm1Jlr/Nkx2-2^tm1Jlr Nkx6-1^tm1Jlr/Nkx6-1^tm1Jlr involves: 129 * 129X1/SvJ * C57BL/6J	decreased pancreatic alpha cell number	J:65594
	decreased pancreatic beta cell number	J:65594
	decreased PP cell number	J:65594
	disorganized pancreatic islets	J:65594
Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Ins2-cre)23Herr/0 involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * CBA/J * SJL	abnormal pancreatic beta cell differentiation	J:177838
Nkx2-2^tm2.1Suss/Nkx2-2^tm2.1Suss Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Pdx1-cre/Esr1)#Dam/0 involves: 129S6/SvEvTac Black Swiss * C57BL/6 * CBA * SJL	abnormal pancreatic beta cell differentiation	J:177838

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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