Nkx3-1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nkx3-1
NK3 homeobox 1
MGI:97352

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Braf^tm1Mmcm/Braf^tm1Mmcm Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺ Pten^tm1Hwu/Pten⁺ involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	increased metastatic potential	J:191327
	increased prostate gland adenocarcinoma incidence	J:191327
	increased prostate gland tumor incidence	J:191327
	increased prostate intraepithelial neoplasia incidence	J:191327
	premature death	J:191327
Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Nkx3-1^tm1.1Saa/Nkx3-1^tm1.1Saa involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	increased prostate intraepithelial neoplasia incidence	J:89571
	preneoplasia	J:89571
Klf6^tm1Fjs/Klf6^tm1Fjs Nkx3-1^tm3(cre)Mms/Nkx3-1⁺ involves: 129/Sv * C57BL/6	abnormal prostate gland anterior lobe morphology	J:153183
	abnormal prostate gland branching morphogenesis	J:153183
	abnormal prostate gland duct morphology	J:153183
Nkx3-1^tm1Mms/Nkx3-1⁺ Pten^tm1Rps/Pten⁺ involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J	increased prostate gland tumor incidence	J:75085
	increased prostate intraepithelial neoplasia incidence	J:75085
Nkx3-1^tm1Mms/Nkx3-1^tm1Mms Pten^tm1Rps/Pten⁺ involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J	increased prostate gland tumor incidence	J:75085
	increased prostate intraepithelial neoplasia incidence	J:75085
Nkx3-1^{tm4(cre/ERT2)Mms}/Nkx3-1⁺ Pten^tm1Hwu/Pten^tm1Hwu involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6	increased prostate gland adenocarcinoma incidence	J:153425
	increased prostate intraepithelial neoplasia incidence	J:153425, J:191327
Nkx3-2^tm1Bobh/Nkx3-2^tm1Bobh Nkx3-1^tm1Hha/Nkx3-1^tm1Hha involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	abnormal axial skeleton morphology	J:79198
	abnormal cartilage development	J:79198
	abnormal cervical atlas morphology	J:79198
	abnormal lumbar vertebrae morphology	J:79198
	abnormal rib morphology	J:79198
	abnormal sclerotome morphology	J:79198
	abnormal vertebrae development	J:79198
	abnormal vertebral body morphology	J:79198
	kinked tail	J:79198
	lethality throughout fetal growth and development, complete penetrance	J:79198

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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