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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Mycn
v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
MGI:97357
106 phenotypes from 11 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Mycntm1.1Nagy/Mycntm1.1Nagy
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:67930
Mycntm1.1Psk/Mycntm1.1Psk
involves: 129 * C57BL/6 		prenatal lethality, complete penetrance J:79489
Mycntm1Fwa/Mycntm1Fwa
involves: 129S/SvEv 		abnormal liver development J:46520
abnormal liver morphology J:46520
decreased hematopoietic stem cell number J:46520
increased hepatocyte apoptosis J:46520
liver hypoplasia J:46520
small liver J:46520
Mycntm1Fwa/Mycntm1Fwa
involves: 129S/SvEv * MF1 		abnormal anterior cardinal vein morphology J:3413
abnormal cardiac epithelial to mesenchymal transition J:3413
abnormal cranial ganglia morphology J:3413
abnormal embryonic neuroepithelium morphology J:3413
abnormal heart development J:3413
abnormal lens vesicle development J:3413
abnormal mesonephros morphology J:3413
abnormal optic vesicle formation J:3413
decreased embryo size J:3413
dorsal root ganglion hypoplasia J:3413
embryonic lethality during organogenesis, complete penetrance J:3413
small dorsal root ganglion J:3413
small trigeminal ganglion J:3413
trabecula carnea hypoplasia J:3413
Mycntm1Jrt/Mycntm1Jrt
involves: 129S2/SvPas * C57BL/6J 		abnormal lung morphology J:973
neonatal lethality, complete penetrance J:973
no spontaneous movement J:973
respiratory distress J:973
Mycntm1Jrt/Mycntm1Par
involves: 129S2/SvPas * C57BL/6J 		abnormal fetal cardiomyocyte proliferation J:15281
abnormal vein morphology J:15281
congestive heart failure J:15281
decreased embryo size J:15281
decreased fetal size J:15281
edema J:15281
embryonic lethality during organogenesis, complete penetrance J:15281
impaired branching involved in bronchus morphogenesis J:15281
normal nervous system phenotype J:15281
normal reproductive system phenotype J:15281
small heart J:15281
small kidney J:15281
thin myocardium J:15281
thin myocardium compact layer J:15281
Mycntm1Knd/Mycntm1Knd
involves: 129P2/OlaHsd * BALB/c 		abnormal apical ectodermal ridge morphology J:11859
abnormal brain morphology J:11859
abnormal limb bud morphology J:11859
abnormal limb development J:11859
abnormal liver development J:11859
abnormal neural tube morphology J:11859
abnormal stomach morphology J:11859
common ventricle J:11859
decreased body length J:11859
embryonic lethality during organogenesis, complete penetrance J:11859, J:76279
impaired branching involved in bronchus morphogenesis J:11859
normal nervous system phenotype J:11859
small dorsal root ganglion J:11859
small heart J:11859
small liver J:11859
thin myocardium J:11859
trabecula carnea hypoplasia J:11859
Mycntm1Nagy/Mycntm1Nagy
involves: 129S1/Sv * 129X1/SvJ 		vertebral fusion J:67930
Mycntm1Nagy/Mycntm2.1Nagy
involves: 129S1/Sv * 129X1/SvJ 		abnormal angiogenesis J:67930
abnormal lung development J:67930
abnormal vertebrae morphology J:67930
abnormal vertebral body development J:67930
absent vitelline blood vessels J:67930
decreased embryo size J:67930
neonatal lethality, complete penetrance J:67930
pale yolk sac J:67930
respiratory failure J:67930
small vertebral body J:67930
thin myocardium J:67930
vertebral fusion J:67930
Mycntm1Par/Mycn+
involves: 129S2/SvPas * C57BL/6J 		postnatal lethality, incomplete penetrance J:3432
Mycntm1Par/Mycntm1Par
involves: 129S2/SvPas * C57BL/6J 		abnormal cranial ganglia morphology J:3432
abnormal dorsal aorta morphology J:3432
abnormal embryo development J:3432
abnormal embryonic neuroepithelial layer differentiation J:3432
abnormal forebrain development J:3432
abnormal intestinal epithelium morphology J:3432
abnormal large intestine morphology J:3432
abnormal lung development J:3432
abnormal medulla oblongata morphology J:3432
abnormal mesonephric mesenchyme morphology J:3432
abnormal mesonephros morphology J:3432
abnormal Wolffian duct morphology J:3432
absent stomach J:3432
anemia J:3432
decreased embryo size J:3432
dilated dorsal aorta J:3432
disorganized dorsal root ganglion J:3432
embryonic growth arrest J:3432
embryonic growth retardation J:3432
embryonic lethality during organogenesis, complete penetrance J:3432
first pharyngeal arch hypoplasia J:3432
gonadal ridge hypoplasia J:3432
hemorrhage J:3432
impaired branching involved in bronchus morphogenesis J:3432
pulmonary hypoplasia J:3432
small dorsal root ganglion J:3432
small trigeminal ganglion J:3432
telencephalon hypoplasia J:3432
thin myocardium J:3432
Mycntm1Psk/Mycn+
Tg(Sftpc-cre)1Blh/0
involves: 129 * C57BL/6 * ICR 		abnormal branching involved in lung morphogenesis J:97215
abnormal lung development J:97215
abnormal lung epithelium morphology J:97215
abnormal lung morphology J:97215
decreased survivor rate J:97215
decreased type I pneumocyte number J:97215
decreased type II pneumocyte number J:97215
neonatal lethality, incomplete penetrance J:97215
Mycntm1Psk/Mycntm1Psk
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		abnormal cerebellar foliation J:79489
abnormal cerebellar granule layer morphology J:79489
abnormal cerebellar molecular layer J:79489
abnormal cerebellar Purkinje cell layer J:79489
abnormal cerebellum development J:79489
abnormal cerebellum external granule cell layer morphology J:79489
abnormal cerebellum morphology J:79489
abnormal cerebral cortex morphology J:79489
abnormal cortical ventricular zone morphology J:79489
abnormal embryonic neuroepithelium morphology J:79489
abnormal neuron differentiation J:79489
abnormal neuronal precursor proliferation J:79489
decreased brain size J:79489
decreased embryonic neuroepithelium thickness J:79489
decreased neuronal precursor cell number J:79489
decreased Purkinje cell number J:79489
ectopic Purkinje cell J:79489
microcephaly J:79489
microphthalmia J:79489
normal nervous system phenotype J:79489
postnatal growth retardation J:79489
premature neuronal precursor differentiation J:79489
small cerebellum J:79489
Mycntm1Psk/Mycntm1Psk
Tg(Sftpc-cre)1Blh/0
involves: 129 * C57BL/6 * ICR 		abnormal branching involved in lung morphogenesis J:97215
abnormal lung development J:97215
abnormal lung epithelium morphology J:97215
abnormal lung morphology J:97215
abnormal pulmonary alveolus epithelial cell morphology J:97215
decreased type I pneumocyte number J:97215
decreased type II pneumocyte number J:97215
neonatal lethality, complete penetrance J:97215
Mycntm2.1Nagy/Mycn+
involves: 129S1/Sv * 129X1/SvJ 		kinked tail J:67930
vertebral fusion J:67930
Mycntm2.1Nagy/Mycntm2.1Nagy
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality during organogenesis, complete penetrance J:67930
Mycntm2Nagy/Mycn+
involves: 129S1/Sv * 129X1/SvJ 		kinked tail J:67930
Mycntm2Nagy/Mycntm2Nagy
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality during organogenesis, complete penetrance J:67930
Tg(Sftpc-Nmyc1/EGFP)1Blh/0
involves: C57BL/6 * DBA 		abnormal lung development J:97215
absent pulmonary alveoli J:97215
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory