Nodal Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nodal
nodal growth differentiation factor
MGI:97359

112 phenotypes from 15 alleles in 18 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Meox2^tm1(cre)Sor/Meox2⁺ Nodal^tm1Rob/Nodal^tm5Rob involves: 129S/SvEv * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	abnormal developmental patterning	J:93140
	abnormal proximal-distal axis patterning	J:93140
	abnormal visceral yolk sac morphology	J:93140
	rostral body truncation	J:93140
Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^{TgR(MPSVNeo)413.dRob} 129S/SvEv-Nodal^{TgR(MPSVNeo)413.dRob}	abnormal developmental patterning	J:11389
	abnormal ectoderm development	J:19211
	abnormal embryonic tissue morphology	J:11389, J:19211
	abnormal extraembryonic ectoderm morphology	J:19211
	abnormal extraembryonic mesoderm development	J:19211
	abnormal extraembryonic tissue morphology	J:19211
	abnormal mesoderm development	J:3969
	abnormal parietal yolk sac morphology	J:11389
	abnormal spongiotrophoblast layer morphology	J:70738
	absent allantois	J:11389
	absent amnion	J:11389
	absent amniotic folds	J:19211
	absent head fold	J:11389
	absent placental labyrinth	J:70738
	absent somites	J:11389
	absent visceral yolk sac	J:11389
	decreased embryo size	J:11389
	embryonic growth arrest	J:19211
	failure of primitive streak formation	J:19211
	increased trophoblast giant cell number	J:70738
	prenatal lethality, complete penetrance	J:11389
	small ectoplacental cone	J:11389
Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^tm1Mku involves: 129S1/Sv	increased spongiotrophoblast size	J:70738
	increased trophoblast giant cell number	J:70738
	thin placenta labyrinth	J:70738
Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^tm4Rob involves: 129S/SvEv * C57BL/6	abnormal embryonic neuroepithelium morphology	J:84300
	abnormal foregut morphology	J:84300
	abnormal heart looping	J:84300
	absent forebrain	J:84300
	absent midbrain	J:84300
	decreased embryonic neuroepithelial cell proliferation	J:84300
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:84300
	enlarged pericardium	J:84300
	pericardial edema	J:84300
	rostral body truncation	J:84300
Nodal^{TgR(MPSVNeo)413.dRob}/Nodal^tm6Rob involves: 129S/SvEv * C57BL/6	abnormal direction of heart looping	J:94418
	abnormal interventricular septum morphology	J:94418
	common atrium	J:94418
	delayed heart development	J:94418
	right pulmonary isomerism	J:94418
	thin myocardium compact layer	J:94418
	trabecula carnea hypoplasia	J:94418
Nodal^tm1.1Hmd/Nodal^tm1.1Hmd involves: 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:97079
Nodal^tm1.1Mku/Nodal^tm2Mku involves: 129S1/Sv	no abnormal phenotype detected	J:142430
Nodal^tm1.1Mku/Nodal^tm2Mku Tg(T-cre)1Lwd/0 involves: 129S1/Sv * C3H * C57BL/6	abnormal direction of heart looping	J:142430
	abnormal interventricular septum morphology	J:142430
	abnormal left-right axis patterning	J:142430
	absent spleen	J:142430
	normal embryo phenotype	J:142430
	right pulmonary isomerism	J:142430
	small spleen	J:142430
	transposition of great arteries	J:142430
Nodal^tm1.1Ysa/Nodal^tm1.1Ysa Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺ involves: C57BL/6 * C57BL/6NTac	abnormal male germ cell morphology	J:191052
Nodal^tm1.2Rob/Nodal^tm3Rob involves: 129S/SvEv * MF1	abnormal direction of heart looping	J:79098
	abnormal heart development	J:79098
	atrial septal defect	J:79098
	common atrium	J:79098
	heterotaxia	J:79098
	neonatal lethality, complete penetrance	J:79098
	right pulmonary isomerism	J:79098
	situs ambiguus	J:79098
	small spleen	J:79098
	transposition of great arteries	J:79098
Nodal^{tm1b(EUCOMM)Wtsi}/Nodal⁺ C57BL/6N-Nodal^{tm1b(EUCOMM)Wtsi}/H	cornea vascularization	J:211773
	decreased locomotor activity	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
	increased circulating triglyceride level	J:211773
	increased grip strength	J:211773
	increased large unstained cell number	J:211773
Nodal^{tm1b(EUCOMM)Wtsi}/Nodal^{tm1b(EUCOMM)Wtsi} C57BL/6N-Nodal^{tm1b(EUCOMM)Wtsi}/H	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Nodal^tm1Hmd/Nodal^tm1Hmd either: (involves: 129S1/Sv * 129X1/SvJ * C57BL/6N) or (involves: 129S1/Sv * 129T2/SvEms * 129X1/SvJ)	abnormal digestive system development	J:82703
	abnormal heart position or orientation	J:82703
	abnormal left-right axis patterning	J:82703
	abnormal liver morphology	J:82703
	abnormal spleen morphology	J:82703
	abnormal stomach position or orientation	J:82703
	embryonic growth arrest	J:82703
	embryonic lethality during organogenesis, incomplete penetrance	J:82703
	perinatal lethality, complete penetrance	J:82703
	right atrial isomerism	J:82703
	right pulmonary isomerism	J:82703
	right-sided isomerism	J:82703
	spleen hypoplasia	J:82703
	transposition of great arteries	J:82703
Nodal^tm1Mku/Nodal^tm1.1Mku either: (involves: 129S1/Sv * FVB/N) or (involves: 129S1/Sv * C57BL/6J * FVB/N)	abnormal anterior visceral endoderm morphology	J:73506
	abnormal brain development	J:73506
	abnormal developmental patterning	J:73506
	abnormal digestive system development	J:73506
	abnormal direction of heart looping	J:73506
	abnormal embryo turning	J:73506
	abnormal embryonic neuroepithelium morphology	J:73506
	abnormal embryonic tissue morphology	J:73506
	abnormal gastrulation	J:73506
	abnormal head development	J:73506
	abnormal hindgut morphology	J:73506
	abnormal lateral plate mesoderm morphology	J:73506
	abnormal neural fold formation	J:73506
	abnormal prechordal plate morphology	J:73506
	abnormal primitive node morphology	J:73506
	abnormal primitive streak morphology	J:73506
	abnormal rostral-caudal axis patterning	J:73506
	abnormal stomach position or orientation	J:73506
	absent floor plate	J:73506
	absent foregut	J:73506
	absent heart tube	J:73506
	absent notochord	J:73506
	absent prechordal plate	J:73506
	absent primitive node	J:73506
	embryonic growth arrest	J:73506
	embryonic lethality, incomplete penetrance	J:73506
	embryonic-extraembryonic boundary constriction	J:73506
	fused somites	J:73506
	holoprosencephaly	J:73506
	pale liver	J:73506
	perinatal lethality, complete penetrance	J:73506
	right pulmonary isomerism	J:73506
	small liver	J:73506
	transposition of great arteries	J:73506
	truncated foregut	J:73506
	truncated notochord	J:73506
Nodal^tm1Mku/Nodal^tm1Mku involves: 129S1/Sv	no abnormal phenotype detected	J:73506
Nodal^tm1Mku/Nodal^tm1Mku Mesp1^tm2(cre)Ysa/Mesp1⁺ Tg(Pitx2-lacZ)1Mbf/0 involves: 129S1/Sv * C57BL/6 * CBA	abnormal heart looping	J:167616
Nodal^tm1Rob/Nodal⁺ involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ	no abnormal phenotype detected	J:32935
Nodal^tm1Rob/Nodal^tm1Rob involves: 129S/SvEv	abnormal developmental patterning	J:32935
	abnormal embryonic tissue morphology	J:32935
	abnormal extraembryonic tissue morphology	J:32935
	decreased embryo size	J:32935
	embryonic growth arrest	J:32935
	prenatal lethality, complete penetrance	J:32935
Nodal^tm1Rob/Nodal^tm2Rob involves: 129S/SvEv * ICR	abnormal gastrulation	J:77125
	abnormal gastrulation movements	J:77125
	abnormal heart looping	J:77125
	abnormal primitive node morphology	J:77125
	abnormal rostral-caudal axis patterning	J:77125
	abnormal visceral endoderm morphology	J:77125
	absent notochord	J:77125
	embryonic-extraembryonic boundary constriction	J:77125
	fused somites	J:77125
Nodal^tm1Rob/Nodal^tm5Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S/SvEv * C57BL/6	abnormal developmental patterning	J:93140
	abnormal distal visceral endoderm morphology	J:93140
	abnormal germ layer development	J:93140
	absent mesoderm	J:93140
Nodal^tm2Rob/Nodal^tm2Rob 129S(Cg)-Nodal^tm2Rob	abnormal mesendoderm development	J:238567
Nodal^tm2Rob/Nodal^tm2Rob 129S(Cg)-Nodal^tm2Rob	rostral body truncation	J:238567
Nodal^tm2Rob/Nodal^tm2Rob involves: 129S/SvEv * ICR	abnormal heart apex morphology	J:77125
	abnormal heart looping	J:77125
	abnormal heart position or orientation	J:77125
	aortic hypertrophy	J:77125
	decreased body size	J:77125
	normal embryo phenotype	J:77125
	premature death	J:77125
	prenatal lethality, incomplete penetrance	J:77125
	right pulmonary isomerism	J:77125
	right-sided isomerism	J:77125
Nodal^tm3Rob/Nodal^tm3Rob Not Specified	no abnormal phenotype detected	J:79098
Nodal^tm4Rob/Nodal^tm4Rob involves: 129/Sv * 129S/SvEv * C57BL/6	abnormal craniofacial development	J:84300
	abnormal heart development	J:84300
	perinatal lethality, complete penetrance	J:84300
	prenatal lethality, incomplete penetrance	J:84300
Nodal^tm6Rob/Nodal^tm6Rob involves: 129S/SvEv * C57BL/6	no abnormal phenotype detected	J:94418

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